Partially Covered Stent-Graft Implantation in Rabbit Aorta: A New Model to Investigate Bioactive Stent-Grafts in Small Animals

Abstract

Partially covered stent-grafts can be safely placed in relatively small animals and potentially used in research.

Gene transduction into aortic wall using plasmid-loaded cationized gelatin hydrogel-coated polyester stent graft

“…First, to facilitate delivery into rabbit aorta via femoral artery, the polyester stent grafts were designed to be partially-covered so that the stent graft profile could be decreased. 20 Furthermore, the radial force of the handmade stent graft to the aortic wall is not sufficiently equivalent due to the configuration of the Z-stent body. This may account for the heterogeneous transduction of plasmid DNA to the aortic tissue.…”

“…20 Polyester fabric with a porosity of 2268 mL/min/cm 2 was sutured on a one-body stainless steel Z-stent with 12 struts. To decrease the stent profile and facilitate its delivery into rabbit aorta via the femoral approach through a 6F catheter introducer, one third of the fabric was cut down.…”

Development of a Novel Rabbit Model of Abdominal Aortic Aneurysm via a Combination of Periaortic Calcium Chloride and Elastase Incubation

“…Tanaka et al [15] introduced a novel rat AAA model induced by a combination of intraluminal elastase infusion and extraluminal CaCl 2 exposure. However, this model is still complex because of the insertion of an SP10 polyethylene catheter into the femoral artery, and rabbits are more suitable than rats for investigating the pharmacologic or gene therapeutic effects of drug-eluting stents and stent graft-mediated gene delivery systems [16], [17], [18], [19]. The purpose of this study was to investigate whether a combination of periaortic CaCl 2 and elastase incubation could work in concert to develop suitable AAA formation in rabbits.…”

A pilot study of a triple antimicrobial-bonded Dacron graft for the prevention of aortic graft infection

“…19 Although dog models have been used to study perioperative graft infections, 20,21 using large animals is costly and time-consuming because general anesthesia with tracheal intubation and large experimental facilities are required. 22 To minimize these expenses, we implanted the grafts in the abdominal aorta rather than in the thoracic aorta and used roof-patch angioplasty rather than a tube- graft replacement to simplify the technique and reduce operative and postoperative morbidities.…”