Partially Parallel Three-Dimensional Magnetic Resonance Imaging for the Assessment of Lung Perfusion – Initial Results

Fink, Christian; Bock, Michael; Puderbach, Michael; Schmähl, A.; Delorme, Stefan

doi:10.1097/01.rli.0000067490.97837.82

Cited by 56 publications

(42 citation statements)

References 21 publications

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“…The availability of a 3-D mGRE technique may also facilitate the use of BOLD MRI in a clinical setting. However, the breathhold duration of 23 seconds may not be 17,18 may further reduce the data acquisition times. The technique may also potentially allow for acquisition of thinner slices and hence isotropic resolution.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Intrarenal Oxygenation at 3.0 T Using 3-Dimensional Multiple Gradient-Recalled Echo Sequence

Tumkur¹,

Vu²,

Li³

et al. 2006

Investigative Radiology

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Objective-The objective of this study was to validate quantitation of R 2 * and ΔR 2 * measurements obtained with a 3-dimensional (3-D) multiple gradient-recalled echo (mGRE) sequence for evaluating intrarenal oxygenation in humans.Materials and Methods-Validation was accomplished (1) by comparing R 2 * values with previously established 2-D techniques (n = 5, mean age = 33.6 years) and (2) by measuring change in ΔR 2 * after furosemide (20 mg intravenously) administration (n = 5, mean age = 22 years). Additional pre-and postfurosemide scans were done at 1.5 T for comparison purposes.Results-R 2 * measurements with the 3-D technique showed good agreement with the 2-D techniques. The baseline medullary R 2 * at 3.0 T was about twice the value found at 1.5 T. Furosemide-induced change in R 2 * was observed within 5 minutes after administration.Conclusions-R 2 * measurements with 3-D mGRE were comparable with those reported using 2-D techniques. The 3-D implementation facilitates observation of temporal changes in the medullary oxygenation without compromising spatial coverage. Keywords kidney; BOLD MRI; 3-D mGRE; oxygenation; 3.0 T The renal medulla operates at low oxygenation levels (renal medullary hypoxia) making it more susceptible to mild reductions in blood flow. 1-3 Renal medullary hypoxia is thought to play a role in the pathogenesis and/or progression of acute renal failure, 4-6 hypertension, 7,8 and diabetic nephropathy. 9,10 Blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) has been used to evaluate intrarenal oxygenation levels noninvasively in humans under normal conditions and during physiological and pharmacologic maneuvers at field strengths of 1.5 T 10-14 and most recently at 3.0 T. 15 To date, all BOLD MRI applied to the human kidney for functional evaluation have used single-shot echo planar (EPI) 13 or 2-dimensional (2-D) breathhold multiple gradient-recalled echo (mGRE) techniques. 14 Despite the advantage of faster acquisition times, the singleshot EPI technique suffers from limitations such as having high sensitivity to susceptibility Copyright © 2006 NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript differences, which can lead to signal loss, image distortions, and increased blurring resulting from T 2 * decay during data acquisition. 14 The 2-D mGRE technique, although efficacious in terms of R 2 * mapping, requires multiple acquisitions to achieve adequate spatial coverage, typically a breathhold for each slice acquisition. In this study, we validated the quantitation of R 2 * and ΔR 2 * using a 3-D implementation of mGRE to perform intrarenal oxygenation studies. R 2 * measurements obtained by the 3-D technique were compared with measurements acquired with the 2-D sequence used in previous studies. Changes in R 2 * (ΔR 2 *) after administration of furosemide were also compared against previous reports.Furosemide is a loop diuretic that has been shown to improve medullary oxygenation, presumably because it selectively decreases ox...

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Section: Discussionmentioning

confidence: 99%

“…However, the breathhold duration of 23 seconds may not be feasible in patients. Fewer numbers of slices and/or use of parallel imaging techniques 17,18 may further reduce the data acquisition times. The technique may also potentially allow for acquisition of thinner slices and hence isotropic resolution.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Intrarenal Oxygenation at 3.0 T Using 3-Dimensional Multiple Gradient-Recalled Echo Sequence

Tumkur¹,

Vu²,

Li³

et al. 2006

Investigative Radiology

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“…Fink et al examined 14 patients with different lung diseases and compared the MR findings with perfusion scintigraphy [49]. The image acquisition for a complete 3D dataset (voxel size 3.6×2.0×5.0 mm 3 ) took 1.5 s. When the results of the ce-perfusion MRI were compared with the perfusion scintigraphy, a good intermodality agreement was observed (kappa=0.74).…”

Section: Pulmonary Circulation: Small Vessels (Perfusion)mentioning

confidence: 99%

Assessment of pulmonary hypertension by CT and MR imaging

et al. 2004

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In the recent World Health Organization (WHO) classification the group of pulmonary arterial hypertension (PH) comprises the classic primary pulmonary hypertension and several conditions with definite or very high risk factors to develop pulmonary arterial hypertension. Therapeutic advances drive the need for a comprehensive pre-therapeutic evaluation for optimal treatment. Furthermore, follow-up examinations need to be performed to monitor changes in disease status and response to therapy. Up to now, the diagnostic imaging work-up of PH comprises mainly echocardiography, invasive right heart catheterization and ventilation/perfusion scintigraphy. Due to technical advances helical computed tomography (CT) and magnetic resonance imaging (MRI) became more important in the evaluation and for differential diagnosis of pulmonary arterial hypertension. Both modalities are reviewed and recommendations for clinical use are given.

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“…The combined use of these techniques can facilitate the differential diagnosis of IPAH and CTEPH [17,18,52,53]. MRPP can provide valuable information for the diagnosis of PH by demonstrating the exact extent of perfusion defects, and has increased diagnostic accuracy in the differentiation of various causes of PAH, depending on the specific patterns of perfusion defects [16,54]. MRI of lung perfusion is performed with rapid imaging of the first passage of contrast material through the lungs after bolus injection into a peripheral vein.…”

Section: Comparison Of Ct and Mri For The Diagnosis In Pulmonary Hypementioning

confidence: 99%

“…Long breath-hold times may be difficult for some patients with pulmonary disorders [16]. MRA allows the integration of morphological and functional information, which increases the diagnostic accuracy of the aetiological causes of PAH based on perfusion defect patterns [54].…”

Section: Comparison Of Ct and Mri For The Diagnosis In Pulmonary Hypementioning

confidence: 99%

Pulmonary arterial hypertension: an imaging review comparing MR pulmonary angiography and perfusion with multidetector CT angiography

Junqueira¹,

Lima²,

Coutinho³

et al. 2012

The British Journal of Radiology

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ABSTRACT. Pulmonary hypertension (PH) is a progressive disease that leads to substantial morbidity and eventual death. Pulmonary multidetector CT angiography (MDCTA), pulmonary MR angiography (MRA) and MR-derived pulmonary perfusion (MRPP) imaging are non-invasive imaging techniques for the differential diagnosis of PH. MDCTA is considered the gold standard for the diagnosis of pulmonary embolism, one of the most common causes of PH. MRA and MRPP are promising techniques that do not require the use of ionising radiation or iodinated contrast material, and can be useful for patients for whom such material cannot be used. This review compares the imaging aspects of pulmonary MRA and 64-row MDCTA in patients with chronic thromboembolic or idiopathic PH.

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Partially Parallel Three-Dimensional Magnetic Resonance Imaging for the Assessment of Lung Perfusion – Initial Results

Abstract: Partially parallel MRI might be used for the assessment of lung perfusion. Future studies are required to further evaluate the diagnostic impact of this technique.

Cited by 56 publications

References 21 publications

Evaluation of Intrarenal Oxygenation at 3.0 T Using 3-Dimensional Multiple Gradient-Recalled Echo Sequence

Evaluation of Intrarenal Oxygenation at 3.0 T Using 3-Dimensional Multiple Gradient-Recalled Echo Sequence

Assessment of pulmonary hypertension by CT and MR imaging

Pulmonary arterial hypertension: an imaging review comparing MR pulmonary angiography and perfusion with multidetector CT angiography

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