Participação dos androgênios adrenais na síndrome dos ovários policísticos

Gil, Angelo Barrionuevo; Rezende, Ana Paula Rodrigues; Carmo, A. V.; Duarte, Erico Isaias; Medeiros, Márcia Marly Winck Yamamoto de; Medeiros, Sebastião Freitas de

doi:10.1590/s0100-72032010001100005

Cited by 12 publications

(9 citation statements)

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“…The highest percentage of physical inactivity in this study may favour the development of CVD especially when associated with smoking [ 21 ]. However, this habit often in the sample was low compared to the study of Junior Gil et al [ 24 ].…”

Section: Discussionmentioning

confidence: 64%

Importance of lipid accumulation product index as a marker of CVD risk in PCOS women

et al. 2015

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BackgroundThe polycystic ovary syndrome (PCOS) is considered the most common endocrine disease during the woman's reproductive life, with prevalence ranging from 5 to 10 % of women of reproductive age. There is a paucity of studies regarding the use of the lipid accumulation product (LAP) as a risk marker for the development of cardiovascular disease (CVD).MethodsA cross-sectional study was conducted on 78 women aged 18 to 42 years seen at University Hospital of Maranhão, with a diagnosis of polycystic ovary syndrome according to the Rotterdam criteria. The following variables of interest were recorded on a protocol form: sociodemographic and behavioral data, body mass index, waist circumference, fasting glucose, total cholesterol, triglycerides, low density lipoprotein cholesterol, high-density lipoprotein cholesterol, and systolic and diastolic blood pressure.ResultsLogistic regression showed that, except for HDL, all cardiovascular risk markers presented a higher chance of being altered when the lipid accumulation product was above the cut off value of 37.9 cm.mmol/L.ConclusionThe lipid accumulation product seems to be sufficient to indicate a risk of cardiovascular diseases in women with polycystic ovary syndrome.

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Section: Discussionmentioning

confidence: 64%

Importance of lipid accumulation product index as a marker of CVD risk in PCOS women

et al. 2015

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“…Previous studies suggest that there is a causal relationship between ovarian cyst formation and adrenal androgen excess (10,11). In adolescents and young women, ovarian cyst formation is more common when there is an increased adrenal androgen concentration, as in polycystic ovary syndrome and CAH due to nonclassical 21-OHD (3,12). The nonclassical form of 21-OHD, as opposed to the classical form, is particularly associated with ovarian cysts because of the long period of nontreatment with resultant androgen excess before diagnosis.…”

Section: Discussionmentioning

confidence: 99%

A Giant Ovarian Cyst in a Neonate with Classical 21-Hydroxylase Deficiency with Very High Testosterone Levels Demonstrating a High-Dose Hook Effect

Güran¹,

Yeşil²,

Güran³

et al. 2012

Jcrpe

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Congenital adrenal hyperplasia (CAH) is a group of disorders affecting the adrenal steroid synthesis. The most common form, 21-hydroxylase deficiency (21-OHD), leads to decreased production of cortisol and aldosterone with increased androgen secretion. In classic CAH, glucocorticoid treatment can be life-saving and serves to bring the symptoms under control. However, the treatment challenge is to effectively control the excess androgen effect by using the lowest possible glucocorticoid dose. Previous studies suggested a relationship between ovarian cyst formation and adrenal androgen excess, but neonatal large ovarian cysts have been very rarely reported in newborns with CAH. Here, we present the unique case of a neonate with classical 21-OHD who underwent surgery for a giant (10x8x7 cm) unilateral solitary ovarian follicular cyst on the 2nd postnatal day. Hormonal evaluation of the patient revealed high-dose hook effect for serum testosterone levels for the first time by a two-site immunoradiometric assay. Possible mechanisms by which androgen excess may cause ovarian cyst formation are discussed. Conflict of interest:None declared.

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“…In these cases, the excess ovarian and adrenal androgen probably disrupts the cyclicity of the gonadotropin release or directly affects the ovary itself, thereby leading to the formation of ovarian cysts. Unlike the salt-losing form of 21-OHD CAH, the non-classical type is more commonly associated with ovarian cysts because of the delayed diagnosis and long periods without treatment (3,10).…”

Section: Discussionmentioning

confidence: 99%

Huge ovarian cyst in a neonate with classical 21-hydroxylase deficiency

Abdelmeguid

Oshiba

Zain

et al. 2021

Clin Pediatr Endocrinol

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Participação dos androgênios adrenais na síndrome dos ovários policísticos

Abstract: the use of multiple endocrine parameters showed a high prevalence of biochemical hyperandrogenism in patients with PCOS. Two thirds of the patients had adrenal hyperandrogenism, and estradiol and insulin did not influence adrenal secretion.

Cited by 12 publications

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Importance of lipid accumulation product index as a marker of CVD risk in PCOS women

Importance of lipid accumulation product index as a marker of CVD risk in PCOS women

A Giant Ovarian Cyst in a Neonate with Classical 21-Hydroxylase Deficiency with Very High Testosterone Levels Demonstrating a High-Dose Hook Effect

Huge ovarian cyst in a neonate with classical 21-hydroxylase deficiency

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