Participation of chemical mediators other than histamine in nasal allergy signs: a study using mice lacking histamine H1 receptors

Kayasuga, Ryoji; Sugimoto, Yukihiko; Watanabe, Takeshi; Kamei, Chiaki

doi:10.1016/s0014-2999(02)02005-8

Cited by 23 publications

(17 citation statements)

References 18 publications

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“…Then, local sensitization was performed every day from day 18 by instilling egg albumin in physiological saline (50 mg/ml/nostril) into the bilateral noses using a micropipette. 9,10) Sneezing and Nasal Rubbing Behavior Induced by Antigen in Sensitized Mice To evaluate nasal rubbing, each time the animal rubbed or touched the area near the nose with its forepaws was counted as one event. Touches around the eyes and mouth were disregarded.…”

Section: Animalsmentioning

confidence: 99%

Effect of Usuhiratake (Pleurotus pulmonarius) on Sneezing and Nasal Rubbing in BALB/c Mice

Yatsuzuka

Nakano

Jiang

et al. 2007

Biological & Pharmaceutical Bulletin

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The anti-rhinitis properties of Pleurotus pulmonarius were investigated in BALB/c mice. A single administration of Pleurotus Pulmonarius caused no significant effect on antigen-induced nasal rubbing and sneezing at a dose of 500 mg/kg, but a significant inhibition was observed after 2 weeks of repeated treatment at this dose, and at a dose of 200 mg/kg, it also caused a significant inhibition after repeated administration for 4 weeks. Pleurotus pulmonarius showed no significant inhibitory effect on the production of IgE. In addition, Pleurotus pulmonarius caused no inhibition of histamine-induced nasal rubbing and sneezing at a dose of 500 mg/kg, but in vitro study, it inhibited histamine release from rat mast cells induced by compound 48/80 at the soluble supernatant solution of 30 and 100 m mg/ml of Pleurotus pulmonarius suspended in PBS. These results demonstrated that Pleurotus pulmonarius may be effective in the relief of symptoms of allergic rhinitis through inhibition of histamine release.

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Section: Animalsmentioning

confidence: 99%

Effect of Usuhiratake (Pleurotus pulmonarius) on Sneezing and Nasal Rubbing in BALB/c Mice

Yatsuzuka

Nakano

Jiang

et al. 2007

Biological & Pharmaceutical Bulletin

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“…Cetirizine has high specificity for the histamine H 1 receptor and is well known to be effective in the treatment of allergic diseases (20). We have also demonstrated that the inhibitory effect of cetirizine on nasal signs occurred only through histamine H 1 receptors from the findings that the drug caused no inhibition of nasal symptoms in histamine H 1 -receptor-deficient mice (21). It has been thought that H 3 receptors are involved in allergic and inflammatory reactions, and H 3 -receptor agonists might represent a novel class of antiinflammatory agents.…”

Section: Discussionmentioning

confidence: 52%

Participation of Histamine H3 Receptors in Experimental Allergic Rhinitis of Mice

et al. 2008

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Abstract. The present study was performed to study the participation of histamine H 3 receptors in nasal symptoms using Sch 50971, a potent and selective agonist of the H 3 receptor. Repeated topical application of antigen caused an increase in sneezing and nasal rubbing in sensitized mice. Oral administration of Sch 50971 and imetit, specific H 3 -receptor agonists, resulted in an inhibition of nasal symptoms induced by an antigen similar to an H 1 -receptor antagonist, cetirizine. Furthermore, simultaneous use of H 3 -receptor agonists, Sch 50971 or imetit, and an H 1 -receptor antagonist, cetirizine, caused a significant inhibitory effect on nasal symptoms at doses that showed no effect when used separately. The number of eosinophils in the nasal mucosa of mice sensitized with antigen was significantly decreased by cetirizine; however, Sch 50971 and imetit had no effect on eosinophil infiltration. These results clearly indicate that H 3 receptors are involved in the etiology of nasal allergy, and the stimulation of H 3 receptors may be useful as a novel therapeutic approach in nasal allergy.

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“…The daily doses of the drugs were determined according to previous reports that could sufficiently inhibited nasal symptoms and some of allergic pathogenesis in ovalbumin-sensitized rodent models. 13,14) Measurement of Nasal Responsiveness to Histamine To estimate the nasal responsiveness to histamine, nasal symptoms were measured after intranasal instillation of a histamine solution. On day 71, 2 ml of vehicle (saline) or of increasing doses of histamine in solution (0.1, 1, 10 nmol/ mouse) was consecutively inserted into each nasal cavity at 60 min intervals.…”

Section: Methodsmentioning

confidence: 99%

Prophylactic Effects of the Histamine H1 Receptor Antagonist Epinastine and the Dual Thromboxane A2 Receptor and Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells Antagonist Ramatroban on Allergic Rhinitis Model in Mice

Suzuki

Inoue

Yamamoto

et al. 2011

Biological & Pharmaceutical Bulletin

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Participation of chemical mediators other than histamine in nasal allergy signs: a study using mice lacking histamine H1 receptors

Cited by 23 publications

References 18 publications

Effect of Usuhiratake (Pleurotus pulmonarius) on Sneezing and Nasal Rubbing in BALB/c Mice

Effect of Usuhiratake (Pleurotus pulmonarius) on Sneezing and Nasal Rubbing in BALB/c Mice

Participation of Histamine H3 Receptors in Experimental Allergic Rhinitis of Mice

Prophylactic Effects of the Histamine H1 Receptor Antagonist Epinastine and the Dual Thromboxane A2 Receptor and Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells Antagonist Ramatroban on Allergic Rhinitis Model in Mice

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