Participation of different cellular types in the enhancement of autoimmune response of old animals to sex accessory glands in male rats: importance of macrophages

Pistoresi-Palencia, María C.; Galmarini, Mirian; Vottero-Cima, E

doi:10.1016/0165-0378(88)90025-3

Cited by 8 publications

(4 citation statements)

References 16 publications

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“…Adoptive transfer experiments have shown that the M@ is the main cellular type of spleen cells involved in the exacerbation of the autoimmune response observed in old rats [5]. The present report shows that one remarkable difference between old and young PC was the I-A and I-E MHC class I1 molecules present on their surface.…”

Section: Discussionsupporting

confidence: 44%

“…Cell transfer experiments have shown that MQ, are the main type of spleen cells involved in this exacerbation. The injection of MQ pulsed in vivo with chemically [I 88331 modified RAG (MRAG) into syngeneic recipients indicated that, although the MQ, from young and old animals were capable of presenting the antigens, the latter showed a significantly greater efficiency for presenting RAG autoantigens with respect to the induction of an autoimmune response [5].…”

Section: Introductionmentioning

confidence: 99%

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Effect of aging on the autoimmune response to rat male accessory glands: deficit of I‐E‐positive peritoneal cells capable of inducing suppression

1991

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The present report analyzes the ability to induce suppression to rat male accessory gland (RAG) autoantigens and the characteristics of T suppressor (Ts)-inducer peritoneal cells (PC) in old rats which show increased autoimmune responses. The injection of young rats with a purified fraction (FI) of RAG 10 and 3 days prior to immunization with chemically modified RAG (MRAG) markedly reduced the immune response to RAG autoantigens when compared with young rats which had only been immunized (controls), while the pretreatment of old rats did not block the delayed-type hypersensitivity reaction to MRAG when compared with control old rats. The study of cell surface markers on PC from rats injected i.p. 2 h previously with FI of RAG (FI-PC) showed an increase of OX-6 (I-A) and a decrease of OX-17 (I-E) in FI-PC of old rats with respect to FI-PC of young animals, which showed a selective increase of I-E+ Ts-inducer PC. The i.p. injection of FI-PC from old rats into young recipients, 10 and 3 days prior to immunization with MRAG in complete Freund's adjuvant, did not modify the autoimmune response when compared with controls. By contrast, the injection of young and old rats with FI-PC from young animals induced a significant suppression of the autoimmune response. The reduced percentage of I-E+ suppressor-inducer PC provides an explanation for the diminished ability to induce suppression to RAG autoantigens in old rats.

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Section: Discussionsupporting

confidence: 44%

Section: Introductionmentioning

confidence: 99%

Effect of aging on the autoimmune response to rat male accessory glands: deficit of I‐E‐positive peritoneal cells capable of inducing suppression

1991

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“…The increased numbers of inflammatory cell populations mainly consisted of CD4+ and CD8+ T cells plus activated macrophages in the later course of the disease [50,52]. The autoimmune character was evidenced by antigen-specific adoptive transfer of spleen cells of autoimmune donors to naïve animals [49,53,54]; the special role in this experiment of T cells [49,53,55], peritoneal dendritic cells [56], and macrophages [55] had been emphasized. Furthermore, MHC class II molecules have been detected on prostate epithelial and interstitial cells in these models, which correlated with the degree of lymphocytic infiltration and functional cell damage [57].…”

Section: Autoimmune Processmentioning

confidence: 91%