Participation of the Nucleus Reticularis Gigantocellularis in the Morphine-Induced Elevation of Plasma Corticosterone in Rats

Kishioka, Shiroh; Tamura, Sadako; Iguchi, Yoshiyuki; Yamamoto, Hiroyuki

doi:10.1254/jjp.38.334

Japanese Journal of Pharmacology

1985

DOI: 10.1254/jjp.38.334

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Participation of the Nucleus Reticularis Gigantocellularis in the Morphine-Induced Elevation of Plasma Corticosterone in Rats

Shiroh Kishioka¹,

Sadako Tamura²,

Yoshiyuki Iguchi³

et al.

Abstract: Abstract-The effects of morphine, adrenocorticotropic hormone (ACTH) and formalin on plasma corticosterone levels were investigated in the nucleus reticularis gigantocellularis (NRGC)-lesioned rats. ACTH (1.0 U/kg) or formalin (6.4%, 0.2 ml/rat) elevated plasma corticosterone in both sham-lesioned and NRGC-lesioned rats at the same degree, while morphine (10 mg/kg) also elevated plasma corticos terone in sham-lesioned rats, the elevation of which was significantly reduced by NRGC-lesioning.These findings sugge… Show more

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1994

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“…Interestingly, the ele vation of PCS is also induced by acute morphine adminis tration (1,5) and the development of tolerance to this hor mone effect follows chronic exposure to morphine (6 8).…”

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confidence: 99%

Quantitative Properties of Plasma Corticosterone Elevation Induced by Naloxone-Precipitated Withdrawal in Morphine-Dependent Rats

Kishioka¹,

Nishida²,

Fukunaga³

et al. 1994

Japanese Journal of Pharmacology

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ABSTRACT-Elevation of plasma corticosterone (PCS) has been used as an indicator of morphine withdrawal, but it is not clear whether the magnitude of elevation is related to the intensity of the dependence. The dose-dependent effects of naloxone on PCS and body weight were studied in male Sprague-Dawley rats rendered physically dependent on morphine by injecting increasing doses of 40-120 mg/kg/day, s.c. twice daily for 1-6 days. Naloxone (0.01-2.0 mg/kg, s.c.) was administered 3 hr after the last morphine administration. Naloxone elevated PCS levels in a dose-dependent manner in all groups treated with morphine, and the elevation was correlated with the number of days of morphine treatment. Naloxone also reduced dose-dependently the body weight in all groups treated with morphine; in this case, a reverse correlation was obtained between the body weight changes and the PCS levels. It was confirmed that PCS elevation is a quantitative sign of naloxone-precipitated morphine withdrawal and that the elevation is indicative of the degree of morphine physical dependence.Keywords: Morphine dependence, Plasma corticosterone, Body weight loss, Naloxone withdrawal Plasma corticosterone (PCS) has been shown to be elevated during both spontaneous and naloxone-precipi tated withdrawal from acute and chronic morphine ex posure, and the elevation of PCS has been used as a meas ure of morphine dependence (1 -4). Interestingly, the ele vation of PCS is also induced by acute morphine adminis tration (1, 5) and the development of tolerance to this hor mone effect follows chronic exposure to morphine (6 8).Intrahypothalamic and intraventricular morphine injec tions elevate PCS (9, 10), and the increase in PCS induced by acute morphine administered systemically is blocked by hypophysectomy or lesions of the median eminence (11,12). Responses of PCS to exogenous corticotropin releasing factor (CRF) and adrenocorticotropic hormone (ACTH) are not attenuated in morphine-tolerant rats, showing that an attenuated PCS response to morphine, i.e., tolerance to the PCS effect, does not occur at the pituitary and adrenal levels (8). Secretion of CRF is stimu lated during the periods of both acute morphine adminis tration (13) and morphine withdrawal (14). These results suggest that the stimulation of PCS secretion and the de velopment of tolerance to the PCS effect of morphine both occurred in the region of the central nervous system involved in the neural control of the hypothalamo-pitui tary-adrenal (HPA) axis. Additionally, the effect of mor phine on PCS is mediated selectively through mu opioid receptor, which in turn is involved in the development of tolerance to the PCS effect of morphine and morphine withdrawal (8,15). Accordingly, if the increase in PCS is a quantitative sign of morphine withdrawal, the understanding of the neural mechanism of PCS elevation during morphine withdrawal would contribute to the elucidation of the un derlying neural mechanism of morphine tolerance and/or dependence. However, little is known about whether the...

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confidence: 99%

Quantitative Properties of Plasma Corticosterone Elevation Induced by Naloxone-Precipitated Withdrawal in Morphine-Dependent Rats

Kishioka¹,

Nishida²,

Fukunaga³

et al. 1994

Japanese Journal of Pharmacology

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Participation of the Nucleus Reticularis Gigantocellularis in the Morphine-Induced Elevation of Plasma Corticosterone in Rats

Cited by 1 publication

References 10 publications

Quantitative Properties of Plasma Corticosterone Elevation Induced by Naloxone-Precipitated Withdrawal in Morphine-Dependent Rats

Quantitative Properties of Plasma Corticosterone Elevation Induced by Naloxone-Precipitated Withdrawal in Morphine-Dependent Rats

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