Participation of the Thalamic CM-Pf Complex  in Attentional Orienting

Minamimoto, Takafumi; Kimura, Minoru

doi:10.1152/jn.2002.87.6.3090

Cited by 175 publications

(143 citation statements)

References 55 publications

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“…Pf neurons project mostly to the caudate nucleus and putamen situated rostral to the anterior commissure, whereas CM neurons project to the posterior part of the putamen (Sadikot et al, 1992). Neurons in the CM-Pf complex respond to multimodal stimuli, especially those presented on the contralateral side to which monkeys paid selective attention (Minamimoto and Kimura, 2002). This evidence could explain the contralateral preference of TAN responses in the caudate nucleus to visual instructions for saccade task (Shimo and Hikosaka, 2001).…”

Section: Discussionmentioning

confidence: 95%

Tonically Active Neurons in the Primate Caudate Nucleus and Putamen Differentially Encode Instructed Motivational Outcomes of Action

Yamada¹,

Matsumoto²,

Kimura³

2004

J. Neurosci.

112

105

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To achieve a goal, animals procure immediately available rewards, escape from aversive events, or endure the absence of rewards. The neuronal substrates for these goal-directed actions include the limbic system and the basal ganglia. In the striatum, tonically active neurons (TANs), presumed cholinergic interneurons, were originally shown to respond to reward-associated stimuli and to evolve their activity through learning. Subsequent studies revealed that they also respond to aversive event-associated stimuli such as an airpuff on the face and that they are less selective to whether the stimuli instruct reward or no reward. To address this paradox, we designed a set of experiments in which macaque monkeys performed a set of visual reaction time tasks while expecting a reward, during escape from an aversive event, and in the absence of a reward. We found that TANs respond to instruction stimuli associated with motivational outcomes (312 of 390; 80%) but not to unassociated ones (51 of 390; 13%), and that they mostly differentiate associated instructions (217 of 312; 70%). We also found that a higher percentage of TANs in the caudate nucleus respond to stimuli associated with motivational outcomes (118 of 128; 92%) than in the putamen (194 of 262; 74%), whereas a higher percentage of TANs in the putamen respond to go signals for the lever release (112 of 262; 43%) than in the caudate nucleus (27 of 128; 21%), especially for an action expecting a reward. These findings suggest a distinct, pivotal role of TANs in the caudate nucleus and putamen in encoding instructed motivational contexts for goal-directed action planning and learning.

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Section: Discussionmentioning

confidence: 95%

Tonically Active Neurons in the Primate Caudate Nucleus and Putamen Differentially Encode Instructed Motivational Outcomes of Action

Yamada¹,

Matsumoto²,

Kimura³

2004

J. Neurosci.

112

105

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“…In this regard, previous electrophysiological studies have documented the heterogeneity of cells in the Pf nucleus based on differences in their responsiveness to different sensory afferent inputs (Matsumoto et al, 2001;Minamimoto and Kimura, 2002). A further differentiation between 'noxious-on' and 'noxious-off' cell types has been reported in rat Pf (Liu et al, 1993).…”

Section: Conclusion Heterogeneity Of Electrophysiological Propertiesmentioning

confidence: 89%

Postnatal maturational properties of rat parafascicular thalamic neurons recorded in vitro

Phelan

Mahler

Deere

et al. 2005

THL

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Thalamic relay neurons have homogeneous, adult-like firing properties and similar morphology by 12 days postnatally (PN 12). Parafascicular (Pf) neurons have a different morphology compared with typical thalamic relay neurons, but the development of their electrophysiological properties is not well studied. Intracellular recordings in PN 12-50 Pf neurons revealed several heterogeneous firing patterns different from those in thalamic relay neurons. Two types of cells were identified: Type I cells displayed a fast afterhyperpolarization (AHP) followed by a large-amplitude, slow AHP; whereas Type II cells had only a fast AHP. These cell types had overlapping membrane properties but differences in excitability. Some properties of Pf neurons were adult-like by PN 12, but, unlike thalamic relay neurons, there were significant maturational changes thereafter, including decreased action potential (AP) duration, increased fast AHP amplitude and increased excitability. Pf neurons did not exhibit rhythmic bursting and generally lacked low-threshold spike (LTS) responses that characterize thalamic relay neurons. Pf neurons exhibited nonlinear I-V relationships, and only a third of the cells expressed the time and voltage-dependent hyperpolarization activated (Ih) current, which declined with age. These results indicate that the morphological differences between Pf neurons and typical thalamic relay neurons are paralleled by electrophysiological differences, and that Pf membrane properties change during postnatal development.

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“…It is also known that inactivation of this input eliminates both the pause and rebound activation of TANs (Matsumoto et al, 2001). By the way of thalamic inputs, it has been suggested that the cholinergic interneurons are in the position to supply the striatum with signals related to attention (Matsumoto et al, 2001;Minamimoto and Kimura, 2002;Ding et al, 2010). Thus, in the search for the origin of prediction error signals in TANs, it remains to determine the extent to which TAN response components might encode some form of attention.…”

Section: Discussionmentioning

confidence: 99%

The Role of Striatal Tonically Active Neurons in Reward Prediction Error Signaling during Instrumental Task Performance

Apicella¹,

Ravel²,

Deffains³

et al. 2011

J. Neurosci.

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The detection of differences between predictions and actual outcomes is important for associative learning and for selecting actions according to their potential future reward. There are reports that tonically active neurons (TANs) in the primate striatum may carry information about errors in the prediction of rewards. However, this property seems to be expressed in classical conditioning tasks but not during performance of an instrumental task. To address this issue, we recorded the activity of TANs in the putamen of two monkeys performing an instrumental task in which probabilistic rewarding outcomes were contingent on an action in block-design experiments. Behavioral evidence suggests that animals adjusted their performance according to the level of probability for reward on each trial block. We found that the TAN response to reward was stronger as the reward probability decreased; this effect was especially prominent on the late component of the pause-rebound pattern of typical response seen in these neurons. The responsiveness to reward omission was also increased with increasing reward probability, whereas there were no detectable effects on responses to the stimulus that triggered the movement. Overall, the modulation of TAN responses by reward probability appeared relatively weak compared with that observed previously in a probabilistic classical conditioning task using the same block design. These data indicate that instrumental conditioning was less effective at demonstrating prediction error signaling in TANs. We conclude that the sensitivity of the TAN system to reward probability depends on the specific learning situation in which animals experienced the stimulus-reward associations.

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Participation of the Thalamic CM-Pf Complex in Attentional Orienting

Cited by 175 publications

References 55 publications

Tonically Active Neurons in the Primate Caudate Nucleus and Putamen Differentially Encode Instructed Motivational Outcomes of Action

Tonically Active Neurons in the Primate Caudate Nucleus and Putamen Differentially Encode Instructed Motivational Outcomes of Action

Postnatal maturational properties of rat parafascicular thalamic neurons recorded in vitro

The Role of Striatal Tonically Active Neurons in Reward Prediction Error Signaling during Instrumental Task Performance

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