Particle deposition in the pulmonary region of the human lung: Multiple breath aerosol transport and deposition

Park, S.S.; Wexler, Anthony S.

doi:10.1016/j.jaerosci.2007.03.005

Cited by 25 publications

(14 citation statements)

References 20 publications

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“…However, during subsequent tides retained particles are transported much deeper into the pulmonary region. In an accompanying paper of this work (Park & Wexler, 2006), we apply effective particle transport profiles and cumulative mixing intensities obtained from this work to predict pulmonary particle transport and deposition during multiple breaths and compare that work to the observations of Davies et al (1972). Therefore, this semi-empirical single-breath model provides a framework for understanding particle transport and deposition during multiple breaths.…”

Section: Discussionmentioning

confidence: 99%

Particle deposition in the pulmonary region of the human lung: A semi-empirical model of single breath transport and deposition

Park

Wexler

2007

Journal of Aerosol Science

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Section: Discussionmentioning

confidence: 99%

Particle deposition in the pulmonary region of the human lung: A semi-empirical model of single breath transport and deposition

Park

Wexler

2007

Journal of Aerosol Science

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“…In the last two decades, CFD simulation has been used for predicting respiratory-tract dosimetry and deposition of inhaled airborne particulate matter or drug particles [12,21,[47][48][49][50][51][52][53][54]. CFD has mainly been used to simulate particle deposition in regional models of the respiratory tract.…”

Section: Respiratory Depositionmentioning

confidence: 99%

“…It has been used to compute aerosol deposition in aerosol sampling/collection devices including impactors [6,26], cyclones [27][28][29][30][31][32], filters [33][34][35][36][37][38][39], and inlets [40][41][42][43][44][45][46]. It has also been used for assessing aerosol deposition in various sections of the human respiratory tract [12,21,[47][48][49][50][51][52][53][54].…”

Section: Introductionmentioning

confidence: 99%

Computational fluid dynamics simulation of aerosol transport and deposition

Tang

Guo

2011

Front. Environ. Sci. Eng. China

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In this article computational fluid dynamics (CFD) simulation of aerosol transport and deposition, i.e. the transport and deposition of particles in an aerosol, is reviewed. The review gives a brief account of the basics of aerosol mechanics, followed by a description of the general CFD approach for flow field simulation, turbulence modeling, wall treatments and simulation of particle motion and deposition. Then examples from the literature are presented, including CFD simulation of particle deposition in human respiratory tract and particle deposition in aerosol devices. CFD simulation of particle transport and deposition may provide information that is difficult to obtain through physical experiments, and it may help reduce the number of experiments needed for device design. Due to the difficulty of describing turbulent flow and particle-eddy interaction, turbulent dispersion of particles remains one of the greatest challenges for CFD simulation. However, it is possible to take a balanced approach toward quantitative description of aerosol dispersion using CFD simulation in conjunction with empirical relations.

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“…The effective diffusion is greater in curved and bifurcated tubes than in straight tubes for secondary flow during HFOV conditions (12)(13)(14) . Thereafter, particle deposition in the distal pulmonary regions of human airways was investigated (15)(16)(17) . In their papers, they calculated the deposition fraction and particle loss due to deposition in each generation on inhalation.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Gas Redistribution in Doubly Bifurcated Respiratory Channel of Human Lung

Ahmmed

Hirahara

Yamamoto

et al. 2011

JBSE

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An oscillatory flow in human lung was investigated with a real scale model channel experimentally. One objective of the present study is to clarify the gas exchange mechanism in the peripheral channel, e.g. from the 18-th to 20-th generations, which are the leading region of gas exchanges. The second object is the inspection of the flow convection under the HFOV (high frequency oscillatory ventilation) condition. The experiment was carried out with a real scale two-dimensional model of airway, instead of using a similarity model, in order to take into account the practical condition of HFOV. The velocity profiles were obtained from ensemble mean measurements and the air trajectories were demonstrated with the ensemble mean velocities in the test section. It was confirmed that the air trajectories of expiration were deviated from those of inspiration in the intermediate zone of our channel. It was predicted that a convective flow mixing might be took place depending on the geometric configuration and the asymmetric compliance ratios of the bronchioles.

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Particle deposition in the pulmonary region of the human lung: Multiple breath aerosol transport and deposition

Cited by 25 publications

References 20 publications

Particle deposition in the pulmonary region of the human lung: A semi-empirical model of single breath transport and deposition

Particle deposition in the pulmonary region of the human lung: A semi-empirical model of single breath transport and deposition

Computational fluid dynamics simulation of aerosol transport and deposition

Investigation of Gas Redistribution in Doubly Bifurcated Respiratory Channel of Human Lung

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