Particle Design Using Supercritical Fluids

Reverchon, Ernesto; Porta, Giovanna Della

doi:10.1002/ceat.200300005

Cited by 47 publications

(28 citation statements)

References 13 publications

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“…So extensive a range of application of salicylic acid defines the high requirements of its purity. A convincing proof of this is provided, in particular, by the results of numerous investigations (for example, [3][4][5][6][7][8][9] of the supercritical state of materials, which were performed in numerous countries during the last decade.…”

Section: Introductionmentioning

confidence: 86%

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The Solubility of Salicylic Acid in Supercritical Carbon Dioxide

et al. 2005

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The possibility of using the method of supercritical fluid extraction for purifying the product of synthesis of salicylic acid is revealed and confirmed experimentally. A continuous-flow experimental setup is used to investigate the solubility of salicylic acid and phenol in supercritical CO 2 and to purify the product of synthesis of salicylic acid at a temperature of 308 K in the pressure range from 7.8 to 12 MPa. The salicylic acid content of the resultant product conforms to the requirements of the State Pharmacopoeia.

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Section: Introductionmentioning

confidence: 86%

“…1) rated for pressures up to 40 MPa and temperatures up to 363 K is a high-pressure vessel 1 with the inside diameter of the housing of 15 mm and volume of 50 cm 3 . All parts of the extractor which contact the working medium were made of Grade 12Kh18N10T (chrome-nickel-titanium) stainless steel.…”

Section: Experimental Setup and Measurement Proceduresmentioning

confidence: 99%

The Solubility of Salicylic Acid in Supercritical Carbon Dioxide

et al. 2005

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“…In the literature, particle formation using supercritical fluids plays an important role in pharmaceutical application for micronization, crystal properties modification, and particle design [8][9][10]. Different kinds of supercritical fluid particle formation techniques classified as RESS (rapid expansion of supercritical solution), SAS (supercritical antisolvent process), SAA (supercritical assisted atomization), and PGSS (particle from gas saturated solution) are well-known in the literature [11].…”

Section: Introductionmentioning

confidence: 99%

Micronization of Fluticasone Propionate using Supercritical Antisolvent (SAS) Process

Lien

2011

Chem Eng & Technol

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The micronization of an asthma active pharmaceutical ingredient, fluticasone propionate, using the supercritical antisolvent (SAS) process was investigated in this study. The most commonly used supercritical carbon dioxide was employed as the antisolvent. The effects of five process parameters, including operating temperature, operating pressure, solution flow rate, solution concentration, and nozzle diameter, were compared and discussed. The physical properties of micronized fluticasone propionate were examined by the particle size analyzer, the scanning electron microscope and X-ray diffractometer. The cross interaction effect of operating temperature and pressure was observed in the SAS treatment of fluticasone propionate and verified by the method of calculated mixture critical point (MCP), using the predictive Soave-Redlich-Kwong equation of state. Operation slightly above the MCP was suggested for successful micronization of fluticasone propionate.

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“…In this study, materials from DIPBAT show higher surface area, which could be related to their lower degree of crystallinity [113]. To understand this issue, it should be noted that particle porosity decreases with increasing crystallinity degree [118] and amorphous or poorly crystalline particles will show, consequently, higher surface areas. …”

Section: Surface Areamentioning

confidence: 94%

Greenhouse Effect Mitigation Through Photocatalytic Technology

Rincón

Camarillo

Martínez

et al. 2014

Environment, Energy and Climate Change I

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Climate change is one of the most critical issues facing the world. One of the pillars of the fight against this phenomenon is the mitigation of greenhouse gas (GHG) emissions, CO 2 in particular. Although many achievements have already been made in CO 2 capture and storage technologies, promising methods to convert waste streams concentrated in this gas into valuable products are currently under way. This chapter intends to describe one of them, the photocatalytic reduction of CO 2 to fuel products, that is, the reaction to produce fuel between the CO 2 molecules and a reducing agent (usually water), in the presence of a semiconductor material that provides electrons (e À ) and holes (h + ) when it is illuminated by light of appropriate energy. Moreover, if solar energy were employed as light source, this type of energy difficult to store could be transformed into liquid or gaseous fuels, useful in conventional power production systems. In this chapter, firstly, a wide review about photocatalysis fundamentals, photocatalysts, synthesis of particles in supercritical fluids, characterization techniques, photocatalytic reactors, etc., is carried out. Subsequently, previous results from the authors' research on this subject are shown. More specifically, the characteristics of photocatalysts synthesized in a supercritical medium to convert CO 2 into fuels are presented and discussed.

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Particle Design Using Supercritical Fluids

Cited by 47 publications

References 13 publications

The Solubility of Salicylic Acid in Supercritical Carbon Dioxide

The Solubility of Salicylic Acid in Supercritical Carbon Dioxide

Micronization of Fluticasone Propionate using Supercritical Antisolvent (SAS) Process

Greenhouse Effect Mitigation Through Photocatalytic Technology

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