Elbow wear is a major threat to the multiphase pipeline transportation industry, which has a negative impact on the stable operation of the transportation system. In order to find the wear reduction methods of elbows in the fluidization pipeline transportation system for 2000-meter-deep coal resources, the swirler was installed upstream of the elbows, and wear simulations and tests of three kinds of elbows were carried out. The results showed that the maximum wear rate (MWR) of elbows increased and then decreased along the elbow angle. Due to the different directions of gravity, the heavy wear position (HWP) of the horizontal-vertical (H-V) elbow was in front of the vertical-horizontal (V-H) elbow. Because the downstream portion of the horizontal-horizontal (H-H) elbow was still a horizontal pipe, the HWP of the H-H elbow almost covered the whole elbow. The swirler placed upstream of the elbows could make the particles at the elbow move to the intrados of the elbows, resulting in less collision between the particles and the extrados of the elbows, thus reducing the wear of the elbows. The wear reduction effects of swirlers on three different elbows were favorably connected with the guide vane angle (GVA) and negatively correlated with the guide vane length (GVL), decreased first and then increased as the guide vane height (GVH) increased, and were little affected by the guide vane number (GVN) and the guide vane thickness (GVT). The mathematical models between the MWR of the elbows and guide vane parameters were established. By bench tests, the wear reduction effect of three kinds of elbows under the optimal guide vane parameters was 58.4%, 76.9%, and 78.6%, respectively. The errors between the bench test results and the simulation results were around 10%.