Particle-related exposure, dose and lung cancer risk of primary school children in two European countries

Pacitto, Antonio; Stabile, Luca; Viana, Mar; Scungio, Mauro; Reche, Cristina; Querol, Xavier; Alastuey, Andrés; Rivas, Ioar; Álvarez-Pedrerol, Mar; Sunyer, Jordi; Drooge, Barend L. van; Grimalt, Joan O.; Sozzi, Roberto; Vigo, Paolo; Buonanno, Giorgio

doi:10.1016/j.scitotenv.2017.10.256

Cited by 53 publications

(23 citation statements)

References 110 publications

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“…Currently, it is a well‐known air pollutant threatening public health. Clinical studies reported that long‐term exposure to the particles associated with reduction in pulmonary function, exacerbation of chronic respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD), and increased incidence and mortality of lung cancer . Epidemiological studies revealed an inverse relationship between the particles inhalation and human average life span .…”

Section: Introductionmentioning

confidence: 99%

“…This process causes fibroblast proliferation and eventually leads to pulmonary fibrosis . In addition, phagocytosing the inhalated particles by lung macrophages leads to a generation of reactive oxygen species (ROS) which further exacerbates particles related lung injury . Therefore, the endogenous anti‐inflammatory and antioxidative reactions will be activated in response to the inflammation and redox imbalance triggered by particles exposure.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Vitamin D protects against particles‐caused lung injury through induction of autophagy in an Nrf2‐dependent manner

Tao

Zhang

Xue

et al. 2019

Environmental Toxicology

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Fine particulate matter is a well-known air pollutant threatening public health. Studies have confirmed long-term exposure to the particles could decrease the pulmonary function, induce asthma exacerbation, and chronic obstructive pulmonary disease, as well as increase the incidence and mortality of lung cancer. A clinical study has explored that the prevalence and risks of vitamin D (VD) deficiency in various chronic disease and toxins induced tissue damage. Our current study aimed to explore the mechanism and further therapeutic potential of VD administration to ameliorate fine particles exposure induced pulmonary damage in vivo and in vitro. To elucidate the effects and mechanisms of VD in particles-induced pulmonary damage, a murine model was established with fine particles intratracheal instillation along with VD intramuscular injection. Our study demonstrated that treatment with VD attenuated particles-induced pulmonary damage and promoted tissue repair by repressing of TGFβ1 signaling pathway and upregulation of MMP9 expression. VD treatment could also regulate the autophagy-related signals along with activation of Nrf2 transcription factor. Furthermore, the results from the in vitro study demonstrated that VD protected against particles-induced cells' damage through the induction of autophagy in an Nrf2-dependent manner. VD treatment caused the degradation of P62 and its bound Keap1, which decreased the Nrf2 ubiquitination and increasing its protein stability. Our work explored a novel potential mechanism in the protection of VD in particlesinduced pulmonary injury and tissue repair, and could further bring insights into exploring antifine particles exposure caused inflammation among other natural products and contributes to inflammation disease medical therapies. K E Y W O R D Sautophagy, fine particulate matter, Nrf2 signals, TGFβ1, vitamin D

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vitamin D protects against particles‐caused lung injury through induction of autophagy in an Nrf2‐dependent manner

Tao

Zhang

Xue

et al. 2019

Environmental Toxicology

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“…In the same way, higher doses of UFP, as a consequence of an elevated environmental UFP concentration, have been correlated to larger lifetime cancer risks. However, not only does the dosage play a decisive role in this health risk, but also the composition of the UFP, with As, Cd, or PAH making a greater contribution to the risk …”

Section: Discussionmentioning

confidence: 99%

Exposure to ultrafine particles in children until 18 years of age: A systematic review

et al. 2019

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Airborne ultrafine particles (UFP) have been related to adverse health effects, but exposure in vulnerable population groups such as children is still not well understood. We aim to review the scientific literature regarding personal exposure to UFP in different microenvironments in populations until 18 years of age. The bibliographical search was carried out in July 2019 using the online database PubMed and was completed with references in articles found in the search. We selected the studies that used continuous counters and measured UFP levels in both specific microenvironment (houses, schools, transport, etc) and personal exposure. Finally, 32 studies fulfilled the criteria: of these, 10 analyzed personal exposure and 22 examined UFP levels in the microenvironment (especially in schools or nurseries (18/22)) and five in various microenvironments (including dwellings and means of transport, where exposure levels were higher). The characteristics of the microenvironments with the greatest levels of UFP were being close to heavy traffic or near cooking and cleaning activities. This review revealed the wide differences in exposure assessment methodologies that could lead to a lack of uniform and comparable information about the real UFP exposure in children.

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“…As part of the atmosphere, aerosols, which are suspensions of solid particles or liquid droplets, are the most common condensate nodules of water droplets, ice crystals, and clouds; additionally, aerosols absorb and scatter solar radiation, participate in various chemical cycles, interact with the Earth's energy budget directly and indirectly (Valsaraj et al, 2009;IPCC, 2013;Allen, 2015;del Aguila et al, 2018;Obregon et al, 2018;Yang et al, 2019), and are hazardous to human health (Butt et al, 2017;Froehlich-Nowoisky et al, 2016;Gutierrez-Avila et al, 2018;Pacitto et al, 2018). Ground-based observation by CE-318 instruments is the traditional approach for measuring high-precision aerosol optical depth (AOD) and supports well-accepted atmospheric pollution studies but is limited by its low spatial resolution and high cost in terms of human, material, and financial resources (Che et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Evaluation and Comparison of MODIS Collection 6.1 and Collection 6 Dark Target Aerosol Optical Depth over Mainland China Under Various Conditions Including Spatiotemporal Distribution, Haze Effects, and Underlying Surface

Huang

Zhu

et al. 2019

Earth and Space Science

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Modifications such as degrading the retrieval quality of mixed pixels in the coastline area and revising surface characterization scheme have been made to the Moderate Resolution Imaging Spectroradiometer (MODIS) Collection 6.1 (C6.1) Dark Target (DT) aerosol optical depth (AOD) product to address inaccuracy over urban areas. In this study, comprehensive evaluations of modifications to the MODIS C6.1 DT AOD product, in comparison with Collection 6 (C6), are conducted over mainland China under different spatial distributions, seasons, and air quality for the period 2010-2017, combined with validation against Aerosol Robotic Network (AERONET) AOD measurements. The preliminary result showed that the C6.1 DT AOD product in China displayed an overall good performance with high R 2 (0.87) and low root-mean-square error (0.23) against ground measurements. Moreover, the C6.1 DT AOD product was an overall improvement over C6, with greater correlation and lower uncertainty against ground measurements, especially for the North China Plain and Central China, although this was not the case for Western China. The improvement was also seasonal, being distinct in spring but less pronounced in winter, and negatively correlated with the level of air pollution. Furthermore, the analysis of DT AOD retrievals in different urbanized areas illustrated that the updated DT algorithm worked well in completely urbanized areas, where 97% of C6.1 DT AOD retrievals were an improvement over C6, while approximately 10% of C6.1 DT AOD retrievals were deteriorated in semiurbanized areas. Additionally, the DT AOD retrievals in areas with relatively low enhanced vegetation index and high surface reflectance were significantly improved, mitigating problems associated with the DT algorithm, further improving the reliability of MODIS DT AOD products. Plain Language Summary Modifications have been made to the Moderate Resolution ImagingSpectroradiometer (MODIS) aerosol optical depth (AOD) product to address inaccuracy over urban areas. This study evaluates the MODIS AOD product in comparison with the old version. Specifically, we evaluated products' performance over mainland China under different spatial distributions, seasons, and air quality for the period 2010-2017. It was demonstrated that the updated AOD retrieval algorithm show a visible improvement in highly urbanized areas, as well as areas with relatively low enhanced vegetation index and high surface reflectance. However, because the surface reflectance scheme was trained over the continental United States, it could not effectively describe the complex surfaces in Eastern and Western China, and therefore, further improvement is required in this regard.

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Particle-related exposure, dose and lung cancer risk of primary school children in two European countries

Cited by 53 publications

References 110 publications

Vitamin D protects against particles‐caused lung injury through induction of autophagy in an Nrf2‐dependent manner

Vitamin D protects against particles‐caused lung injury through induction of autophagy in an Nrf2‐dependent manner

Exposure to ultrafine particles in children until 18 years of age: A systematic review

Evaluation and Comparison of MODIS Collection 6.1 and Collection 6 Dark Target Aerosol Optical Depth over Mainland China Under Various Conditions Including Spatiotemporal Distribution, Haze Effects, and Underlying Surface

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