Particle separation in microfluidics using different modal ultrasonic standing waves

Zhang, Yaolong; Chen, Xueye

doi:10.1016/j.ultsonch.2021.105603

Cited by 25 publications

(6 citation statements)

References 28 publications

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“…The produced waves consist of two standing pressure nodes at the microchannel’s sides and a single antinode at the channel’s center. The resonant frequency will cause the PS particles of the positive acoustic contrast factor to migrate toward the pressure nodes [ 51 , 52 ] located at the channel centerline, as illustrated in Figure 6 .…”

Section: Device Design and Experimental Setupmentioning

confidence: 99%

Numerical Modeling Using Immersed Boundary-Lattice Boltzmann Method and Experiments for Particle Manipulation under Standing Surface Acoustic Waves

et al. 2023

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In this work, we employed the Immersed Boundary-Lattice Boltzmann Method (IB-LBM) to simulate the motion of a microparticle in a microchannel under the influence of a standing surface acoustic wave (SSAW). To capture the response of the target microparticle in a straight channel under the effect of the SSAW, in-house code was built in C language. The SSAW creates pressure nodes and anti-nodes inside the microchannel. Here, the target particle was forced to traverse toward the pressure node. A mapping mechanism was developed to accurately apply the physical acoustic force field in the numerical simulation. First, benchmarking studies were conducted to compare the numerical results in the IB-LBM with the available analytical, numerical, and experimental results. Next, several parametric studies were carried out in which the particle types, sizes, compressibility coefficients, and densities were varied. When the SSAW is applied, the microparticles (with a positive acoustic contrast factor) move toward the pressure node locations during their motion in the microchannel. Hence, their steady-state locations are controlled by adjusting the pressure nodes to the desired locations, such as the centerline or near the microchannel sidewalls. Moreover, the geometric parameters, such as radius, density, and compressibility of the particles affect their transient response, and the particles ultimately settle at the pressure nodes. To validate the numerical work, a microfluidic device was fabricated in-house in the cleanroom using lithographic techniques. Experiments were performed, and the target particle was moved either to the centerline or sidewalls of the channel, depending on the location of the pressure node. The steady-state placements obtained in the computational model and experiments exhibit excellent agreement and are reported.

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Section: Device Design and Experimental Setupmentioning

confidence: 99%

Numerical Modeling Using Immersed Boundary-Lattice Boltzmann Method and Experiments for Particle Manipulation under Standing Surface Acoustic Waves

et al. 2023

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“…More specifically, FEM codes have been used to optimize several variables and parameters that affect the process, such as the applied voltage or the effect of the IDTs location (distance from the channel and angle), number of IDT fingers, microchannel's height, the main flow velocity, and flow rate, etc. [8,19,71,74]. As seen in Table 3, the separation of cells via acoustophoresis, mostly blood cells, has been successfully modeled and optimized using numerical models.…”

Section: Acoustophoretic Separationmentioning

confidence: 99%

Novel Approaches Concerning the Numerical Modeling of Particle and Cell Separation in Microchannels: A Review

Karampelas¹,

Gómez-Pastora

2022

Processes

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The demand for precise separation of particles, cells, and other biological matter has significantly increased in recent years, leading to heightened scientific interest in this topic. More recently, due to advances in computational techniques and hardware, numerical simulations have been used to guide the design of separation devices. In this article, we establish the theoretical basis governing fluid flow and particle separation and then summarize the computational work performed in the field of particle and cell separation in the last five years with an emphasis on magnetic, dielectric, and acoustic methods. Nearly 70 articles are being reviewed and categorized depending on the type of material separated, fluid medium, software used, and experimental validation, with a brief description of some of the most notable results. Finally, further conclusions, future guidelines, and suggestions for potential improvement are highlighted.

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“…In this study, a homogeneous IDT was used. Its design process can be described using the following equation where λ is the wavelength, M is the periodic node length, v s is the wave velocity, and f and is the excitation frequency.…”

Section: Design Of the Rayleigh Saw Devicementioning

confidence: 99%

Novel Study on the Mixing Mechanism of Active Micromixers Based on Surface Acoustic Waves

Chen

2022

Ind. Eng. Chem. Res.

Self Cite

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The method of using a surface acoustic wave (SAW) to drive fluid mixing on a microfluidic chip has been widely investigated by researchers because of its advantages of not directly contacting the fluid and not changing the chemical properties of the fluid. In this paper, we investigate the potential mechanism of SAW-driven fluid mixing. A SAW device is designed by us and modal and harmonic response analyses are performed on it. Because the mechanisms of the traveling SAW (TSAW) and the standing SAW (SSAW) on a fluid are different, we have performed transient simulations for each of them in order to clearly understand their differences. The effect of voltage values on the intensity of acoustic pressure is also studied by us. Finally, we perform a comprehensive analysis of acoustic-fluid force-driven fluid mixing. For TSAW- and SSAW-driven fluid mixing, we discuss and analyze the mixing effect at different voltages separately. The velocity fields of the two types of SAW-driven micromixers are also investigated. It is found that the mixing effect of both micromixers is enhanced with increasing voltage. However, the TSAW-driven micromixer produces a single vortex flow through the channel in the acoustic action region, while the SSAW-driven micromixer produces a symmetric double vortex flow. The difference between the TSAW- and SSAW-driven fluids can be clearly analyzed by the velocity field results. The TSAW drives the fluid mainly on one side of the microchannel, while the SSAW drives the fluid by superposition of the acoustic flow force on both sides of the microchannel. The results of this study contribute to a better understanding of the SAW-driven effect on the flow properties of fluids. Moreover, this work lays a theoretical foundation for practical applications in areas such as biochemical reactions and polymer synthesis.

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Particle separation in microfluidics using different modal ultrasonic standing waves

Cited by 25 publications

References 28 publications

Numerical Modeling Using Immersed Boundary-Lattice Boltzmann Method and Experiments for Particle Manipulation under Standing Surface Acoustic Waves

Numerical Modeling Using Immersed Boundary-Lattice Boltzmann Method and Experiments for Particle Manipulation under Standing Surface Acoustic Waves

Novel Approaches Concerning the Numerical Modeling of Particle and Cell Separation in Microchannels: A Review

Novel Study on the Mixing Mechanism of Active Micromixers Based on Surface Acoustic Waves

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