Particle shape: A new design parameter for micro- and nanoscale drug delivery carriers

Champion, Julie A.; Katare, Yogesh K.; Mitragotri, Samir

doi:10.1016/j.jconrel.2007.03.022

Cited by 1,106 publications

(851 citation statements)

References 39 publications

Supporting

Mentioning

834

Contrasting

Unclassified

Order By: Relevance

“…Recreation of the complex morphology of RBCs in a synthetic system has proved challenging using currently established techniques (20). We adopted a biomimetic strategy to prepare RBC-shaped particles.…”

Section: Resultsmentioning

confidence: 99%

Red blood cell-mimicking synthetic biomaterial particles

Doshi

Zahr

Bhaskar³

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

342

280

View full text Add to dashboard Cite

Biomaterials form the basis of current and future biomedical technologies. They are routinely used to design therapeutic carriers, such as nanoparticles, for applications in drug delivery. Current strategies for synthesizing drug delivery carriers are based either on discovery of materials or development of fabrication methods. While synthetic carriers have brought upon numerous advances in drug delivery, they fail to match the sophistication exhibited by innate biological entities. In particular, red blood cells (RBCs), the most ubiquitous cell type in the human blood, constitute highly specialized entities with unique shape, size, mechanical flexibility, and material composition, all of which are optimized for extraordinary biological performance. Inspired by this natural example, we synthesized particles that mimic the key structural and functional features of RBCs. Similar to their natural counterparts, RBC-mimicking particles described here possess the ability to carry oxygen and flow through capillaries smaller than their own diameter. Further, they can also encapsulate drugs and imaging agents. These particles provide a paradigm for the design of drug delivery and imaging carriers, because they combine the functionality of natural RBCs with the broad applicability and versatility of synthetic drug delivery particles.biomimetic ͉ drug delivery ͉ erythrocyte ͉ imaging ͉ nanotechnology

show abstract

Section: Resultsmentioning

confidence: 99%

Red blood cell-mimicking synthetic biomaterial particles

Doshi

Zahr

Bhaskar³

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

342

280

View full text Add to dashboard Cite

show abstract

“…The motivation to develop particles with switchable shapes comes from the fact that shape has recently emerged as a crucial design parameter of micro-and nanoparticles (3,4,33,38,39). Studies have demonstrated that departure from the conventional spherical shape of particles brings unique and improved functionalities to the particulate systems, resulting in improved biological responses.…”

Section: Discussionmentioning

confidence: 99%

“…The outcome of these interactions relies on optimal selection of key particle properties including surface chemistry, size, and shape (3,4). Accordingly, numerous studies have reported on methods to synthesize materials with precisely engineered functional attributes such as size, surface chemistry, mechanical properties, and shape to facilitate or mitigate interactions with various cell types (3)(4)(5).…”

mentioning

confidence: 99%

Polymer particles that switch shape in response to a stimulus

Yoo

Mitragotri²

2010

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

237

199

View full text Add to dashboard Cite

Particle engineering for biomedical applications has unfolded the roles of attributes such as size, surface chemistry, and shape for modulating particle interactions with cells. Recently, dynamic manipulation of such key properties has gained attention in view of the need to precisely control particle interaction with cells. With increasing recognition of the pivotal role of particle shape in determining their biomedical applications, we report on polymeric particles that are able to switch their shape in real time in a stimulusresponsive manner. The shape-switching behavior was driven by a subtle balance between polymer viscosity and interfacial tension. The balance between the two forces was modulated by application of an external stimulus chosen from temperature, pH, or chemical additives. The dynamics of shape switch was precisely controlled over minutes to days under physiological conditions. Shapeswitching particles exhibited unique interactions with cells. Elliptical disk-shaped particles that are not phagocytosed by macrophages were made to internalize through shape switch, demonstrating the ability of shape-switchable particles in modulating interaction with cells.drug delivery | carrier | geometry | nanotechnology | phagocytosis I nteractions of polymeric particles with various cells, including macrophages, in the form of endocytosis and phagocytosis determine the effectiveness of carriers used for drug delivery and medical imaging (1, 2). The outcome of these interactions relies on optimal selection of key particle properties including surface chemistry, size, and shape (3, 4). Accordingly, numerous studies have reported on methods to synthesize materials with precisely engineered functional attributes such as size, surface chemistry, mechanical properties, and shape to facilitate or mitigate interactions with various cell types (3-5).For a given application, particle properties are optimized through extensive experimentation, and a set of fixed values are then chosen for further development. In reality, however, the optimal values of parameters may vary with time depending on the application. This variation has motivated the need to gain dynamic control over key particle properties so as to achieve an interactive interface between the particles and the complex biological milieu. For example, studies have reported on stimulusresponsive type control over the size of particles, and such particles have been used for the triggered release of encapsulated drugs (6-8). In another study, the surface chemistry of polymeric micelles has been controlled by using the environmental pH of solid tumors so as to enhance the cellular uptake and release of anticancer agents (9). Studies have also reported on achieving dynamic control of surface properties through the use of electric fields (10). Relatively little attention, however, has been devoted to switching particle's shape.Here we report poly(lactide-co-glycolide) (PLGA) particles whose shape can be switched in real time from an elliptical disk to a sphere in re...

show abstract

“…However, the movements of non-spherical (anisotropic) particles are much more complex because such particles may align or tumble inside a fl uidic stream. [ 88 ] For example, fi lamentous fl exible micelles (fi lomicelles from di-block copolymers such as poly(ethylene glycol)-poly(caprolactone) (PEG-PCL) and poly(ethylene glycol)-poly(ethyl ethylene) (PEG-PEE)) remain in the blood circulation for more time than spherical and shorter fi lomicelles due to their alignment with the blood fl ow. [ 95 ] Diskshaped liposomes also demonstrated higher circulation time when compared with spherical counterparts.…”

Section: Effect On Circulation and Biodistributionmentioning

confidence: 99%

Design Advances in Particulate Systems for Biomedical Applications

Lima

Álvarez-Lorenzo

Mano

2016

Adv Healthcare Materials

View full text Add to dashboard Cite

Particulate systems have been widely used as containers of drugs or cells with the purpose of releasing them in a particularThe search for more effi cient therapeutic strategies and diagnosis tools is a continuous challenge. Advances in understanding the biological mechanisms behind diseases and tissues regeneration have widened the fi eld of applications of particulate systems. Particles are no more just protective systems for the encapsulated drugs, but they play an active role in the success of the therapy. Moreover, particles have been explored for innovative purposes as templates for cells growth and as diagnostic tools. Until few years ago the most relevant parameters in particles formulation were the chemistry and the size. Currently, it is known that other physical characteristics can remarkably affect the performance of particulate systems. Particles with non-conventional shapes exhibit advantages due to the increasing circulation time in blood stream, less clearance by the immune system and more effi cient cell internalization and traffi cking. Creation of compartments has been found useful to control drug release, to tune the transport of substances across biological barriers, to supply the target with more than one bioactive agent or even to act as theranostic systems. It is expected that such complex shaped and compartmentalized systems improve the therapeutic outcomes and also the patient's compliance, acting as advanced devices that serve for simultaneous diagnosis and treatment of the disease, combining agents of very different features, at the same time. In this review, we overview and analyse the most recent advances in particle shape and compartmentalization and applications of newly designed particulate systems in the biomedical fi eld.

show abstract

Particle shape: A new design parameter for micro- and nanoscale drug delivery carriers

Cited by 1,106 publications

References 39 publications

Red blood cell-mimicking synthetic biomaterial particles

Red blood cell-mimicking synthetic biomaterial particles

Polymer particles that switch shape in response to a stimulus

Design Advances in Particulate Systems for Biomedical Applications

Contact Info

Product

Resources

About