Particle size-dependent organ distribution of gold nanoparticles after intravenous administration

Jong, Wim H. de; Hagens, Werner I.; Krystek, Petra; Burger, Marion; Sips, A. J. A. M.; Geertsma, Robert E.

doi:10.1016/j.biomaterials.2007.12.037

Cited by 1,423 publications

(1,068 citation statements)

References 27 publications

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“…2 In addition, Jong et al reported that sizes of GNPs affect their distribution in organs. 48 They injected rats with different size of 10, 50, 100, and 250 nm GNPs, 24 h later, blood and various organs were collected for gold quantity by inductively coupled plasma mass spectrometry (ICP-MS). Results showed that majority of GNPs were found in liver and spleen.…”

Section: Sizementioning

confidence: 99%

Cellular Uptake, Intracellular Trafficking and Biological Responses of Gold Nanoparticles

Jiang

Wang

Chen

2011

J Chinese Chemical Soc

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Promising application of gold nanoparticles (GNPs) in biomedical and environmental fields is increasing the likelihood of direct interaction with living systems. The knowledge about GNPs interacting with cells is quite limited and however, is necessary for risk prediction and evaluation of biological effects. Herein, we review recent advances in cellular effects of GNPs including cellular uptake, trafficking, subcellular distribution and cellular responses, and the relationship between physiochemical properties of GNPs and biological effects as well. To uncover these issues, it is quite instructive for safe and sustainable use of GNPs.

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Section: Sizementioning

confidence: 99%

Cellular Uptake, Intracellular Trafficking and Biological Responses of Gold Nanoparticles

Jiang

Wang

Chen

2011

J Chinese Chemical Soc

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“…As compared to molecular dye‐ligand conjugates, the multiple targeting ligands presented on NP surfaces allow multivalent recognition and binding to receptors on cell membrane, resulting in higher binding affinity and much improved selectivity toward targeted cells 9, 10, 11. With the rapid advances of nanotechnology, versatile NP systems including semiconducting quantum dots (QDs), gold NPs, and dye encapsulated NPs, etc., have been developed 12, 13, 14, 15, 16. Despite the fact that NPs with varied sizes have been designed for different biomedical applications,17, 18, 19 there has been limited success in highly selective cancer targeting, and only a few examples for inorganic gold NPs were reported 16, 20.…”

Section: Introductionmentioning

confidence: 99%

Ultrasmall Conjugated Polymer Nanoparticles with High Specificity for Targeted Cancer Cell Imaging

Feng

Liu

et al. 2017

Advanced Science

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Fluorescent and biocompatible organic nanoparticles have attracted great interest in cancer detection and imaging, but the nonspecific cellular uptake has limited the detection specificity and sensitivity. Herein, the authors report the ultrasmall conjugated polymer nanoparticles (CPNs) with bright far‐red/near‐infrared emission for targeted cancer imaging with high specificity. The sizes of the ultrasmall CPNs are around 6 nm (CPN6), while large CPNs show sizes around 30 nm (CPN30). Moreover, CPN6 exhibits largely improved fluorescence quantum yield (η) of 41% than CPN30 (25%). Benefiting from the ultrasmall size, bare CPN6 shows largely suppressed nonspecific cellular uptake as compared to CPN30, while cyclic arginine‐glycine‐aspartic acid (cRGD) functionalized CPN6 (cRGD‐CPN6) possesses excellent selectivity toward αvβ 3 integrin overexpressed MDA‐MB‐231 cells over other cells in cell mixtures. The faster body clearance of CPN6 over CPN30 indicates its greater potentials as a noninvasive nanoprobe for in vivo and practical applications.

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“…The results revealed that the tissue distribution of Au NPs was size-dependent, with the smallest NPs (15 nm) showing the most widespread organ distribution [111]. Moreover, for all Au NP sizes the majority of the Au was demonstrated to be present in liver and spleen [112].…”

Section: Direct Inductively Coupled Plasma Mass Spectrometry Analysismentioning

confidence: 95%

“…Au, Ag and Cd) ensure a relatively low spectral background. Very recently, ICP-MS was used to study the biodistribution of Au NPs after intravenous administration in mice [111,112]. Au NPs of different sizes, mainly 15, 50, 100 and 200 nm, were synthesised.…”

Section: Direct Inductively Coupled Plasma Mass Spectrometry Analysismentioning

confidence: 99%

Inorganic mass spectrometry as a tool for characterisation at the nanoscale

et al. 2009

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Inorganic mass spectrometry techniques may offer great potential for the characterisation at the nanoscale, because they provide unique elemental information of great value for a better understanding of processes occurring at nanometre-length dimensions. Two main groups of techniques are reviewed: those allowing direct solid analysis with spatial resolution capabilities, i.e. lateral (imaging) and/or indepth profile, and those for the analysis of liquids containing colloids. In this context, the present capabilities of widespread elemental mass spectrometry techniques such as laser ablation coupled with inductively coupled plasma mass spectrometry (ICP-MS), glow discharge mass spectrometry and secondary ion/neutral mass spectrometry are described and compared through selected examples from various scientific fields. On the other hand, approaches for the characterisation (i.e. size, composition, presence of impurities, etc.) of colloidal solutions containing nanoparticles by the well-established ICP-MS technique are described. In this latter case, the capabilities derived from the on-line coupling of separation techniques such as field-flow fractionation and liquid chromatography with ICP-MS are also assessed. Finally, appealing trends using ICP-MS for bioassays with biomolecules labelled with nanoparticles are delineated.

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Particle size-dependent organ distribution of gold nanoparticles after intravenous administration

Cited by 1,423 publications

References 27 publications

Cellular Uptake, Intracellular Trafficking and Biological Responses of Gold Nanoparticles

Cellular Uptake, Intracellular Trafficking and Biological Responses of Gold Nanoparticles

Ultrasmall Conjugated Polymer Nanoparticles with High Specificity for Targeted Cancer Cell Imaging

Inorganic mass spectrometry as a tool for characterisation at the nanoscale

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