2005
DOI: 10.4028/www.scientific.net/msf.475-479.2403
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Particle Size Reduction of Biomaterials Using Cryogenic Milling Process

Abstract: Reducing the particle size of drug materials down to submicron is an important matter in pharmaceutical industry. Cryogenic milling technology is one of the mechanical milling processes, which is mostly utilized in refining grain size of metal and ceramics at extremely low temperature environment. This technique has not been readily studied in application to medical and biotechnology. This paper, therefore, describes the application of cryogenic milling process to reduce particle size of Ibuprofen. The shape a… Show more

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Cited by 4 publications
(2 citation statements)
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“…The two conventional and straightforward size reduction methods are comminution (grinding, milling) and spray drying. Both methods apply mechanical stress for the disaggregation of the active compound, but the smallest attainable sizes still remain in the micrometer regime 8 , 9 . Advanced methods can reach the upper part of sub-micrometer ranges but the procedures involved are sometimes complicated or need additional materials, which makes it more difficult to produce particles in this size range 10 13 .…”
Section: Introductionmentioning
confidence: 99%
“…The two conventional and straightforward size reduction methods are comminution (grinding, milling) and spray drying. Both methods apply mechanical stress for the disaggregation of the active compound, but the smallest attainable sizes still remain in the micrometer regime 8 , 9 . Advanced methods can reach the upper part of sub-micrometer ranges but the procedures involved are sometimes complicated or need additional materials, which makes it more difficult to produce particles in this size range 10 13 .…”
Section: Introductionmentioning
confidence: 99%
“…It has also been reported in previous studies that both ball milling at room temperature and cryogenic ball milling of IB only slightly reduced its crystallinity. 49 For plain PA to dissolve in phosphate buffer pH 7.2, it took 40 min ( Fig. 5c; data not shown in table), and in co-amorphous form showed 80% dissolution in 0.1 N HCl, in 20 min (Fig.…”
Section: In-vitro Dissolution Studiesmentioning
confidence: 95%