The purpose of the study: is to investigate the efficiency of the developed physical rehabilitation program in the late rehabilitation period after ischemic stroke with a personalized approach with the priority use of the "OSNOVA" device for the restoration of locomotor functions. Material & Methods: to implement a physical rehabilitation program in the late rehabilitation period after ischemic stroke with a personalized approach with the priority use of the "OSNOVA" device for the restoration of locomotor functions, 10 patients diagnosed with ischemic stroke in the late rehabilitation period after undergoing sanatorium treatment were involved. Because the patients differed in pathogenesis (flaccid and spastic paralysis, left or right-sided), a personalized physical rehabilitation program was applied to each patient, but with elements of correction depending on the patient’s dynamics. All participants signed an informed consent form to participate in the study. The study used general and clinical methods of examination (medical history, patient examination), the NIHSS (National Institutes of Health Stroke Scale) scale, which allows an objective approach to the patient's condition after a stroke and assesses neurological status, and the MMSE (Mini Mental State Examination) scale, which assesses mental state and cognitive function. Also, to implement the developed program, a device for restoring locomotor functions – "Osnova" – was developed. Results: a program of physical rehabilitation in the late rehabilitation period after ischemic stroke with a personalized approach with the priority use of the device "OSNOVA" was developed, which was conducted for three weeks and included three stages and the volume of training hours – 90. A "success diary" was introduced to motivate and monitor the workload during training. The data obtained showed that the average Barthel scale score is 77.1 against the initial value of 64. It should be noted that the scores increased by 17%. The NIHSS scale is 13.9 against the initial value of 10.1. We note that the scores have increased by 27%. Conclusions: the results obtained showed positive dynamics, but the development of a standard rehabilitation protocol is an open question, as there is currently insufficient data to determine the optimal duration of procedures and their intensity.