Grain dust has a long history of association with disease, and its effects on various organs have been reported for many years. Inflammatory diseases of the eyes, nose, and skin may be caused by both direct irritation and immune-based reactions. The lung and airways frequently suffer adverse effects. Asthma is well documented as being a result of exposure. Several studies show increased incidences of respiratory symptoms and of reduced pulmonary function in grain workers. Grain dust should be regarded as a dust with toxic properties, not just a nuisance dust.