Partitioning of hydrophobic organic contaminants between polymer and lipids for two silicones and low density polyethylene

Smedes, Foppe; Rusina, Tatsiana P.; Beeltje, Henry; Mayer, Philipp

doi:10.1016/j.chemosphere.2017.08.044

Cited by 41 publications

(58 citation statements)

References 28 publications

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“…(B) Correlation of log K lipid/water with log K ow (line: log K lipid/water = 0.94 log K ow + 0.90, r 2 = 0.914) and of log K lipid/PDMS with log K ow (line: log K lipid/PDMS = 0.13 log K ow + 0.53, r 2 = 0.35). (C) log K lipid/water of the pork adipose tissue in comparison with log K lipid/water from the literature (mean of diverse oils, corn oil, fish oil, , and fish) and predictions using the LSER from Geisler et al…”

Section: Resultsmentioning

confidence: 99%

Kinetics of Equilibrium Passive Sampling of Organic Chemicals with Polymers in Diverse Mammalian Tissues

Baumer

Jäsch

Ulrich

et al. 2021

Environ. Sci. Technol.

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Equilibrium passive sampling employing polydimethylsiloxane (PDMS) as a sampling phase can be used for the extraction of complex mixtures of organic chemicals from lipid-rich biota. We extended the method to lean tissues and more hydrophilic chemicals by implementing a mass-balance model for partitioning between lipids, proteins, and water in tissues and by accelerating uptake kinetics with a custom-built stirrer that effectively decreased time to equilibrium to less than 8 days even for a homogenized liver tissue with an only 4% lipid content. The partition constants log K lipid/PDMS between tissues and PDMS were derived from measured concentration in PDMS and the mass-balance model and were very similar for 40 neutral chemicals with octanol–water partition constants 1.4 < log K ow < 8.7, that is, log K lipid/PDMS of 1.26 (95% CI, 1.13–1.39) for the adipose tissue, 1.16 (1.00–1.33) for the liver, and 0.58 (0.42–0.73) for the brain. This conversion factor can be applied to interpret chemical analysis and in vitro bioassays after additionally accounting for a small fraction of coextracted lipids of <0.7% of the PDMS weight. PDMS is more widely applicable for passive sampling of mammalian tissues than previously thought, both, in terms of diversity of chemicals and the range of lipid contents of tissues and, therefore, an ideal method for human biomonitoring to be combined with in vitro bioassays.

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Section: Resultsmentioning

confidence: 99%

Kinetics of Equilibrium Passive Sampling of Organic Chemicals with Polymers in Diverse Mammalian Tissues

Baumer

Jäsch

Ulrich

et al. 2021

Environ. Sci. Technol.

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“…For neutral lipids, these K LP values are not lipid-specific and are available for PCB, PeCB, HCB, and DDx. 24,25 The K LP values for BDE were estimated as the ratio of C L and C P equilibrated with fillet by EPS for the samples from sites B and C (highest BDE levels), as described for SSP in S9-1.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Unraveling the Relationship between the Concentrations of Hydrophobic Organic Contaminants in Freshwater Fish of Different Trophic Levels and Water Using Passive Sampling

Smedes

Sobotka

Rusina

et al. 2020

Environ. Sci. Technol.

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The concentrations of hydrophobic organic compounds (HOCs) in aquatic biota are used for compliance, as well as time and spatial trend monitoring in the aqueous environment (European Union water framework directive, OSPAR). Because of trophic magnification in the food chain, the thermodynamic levels of HOCs, for example, polychlorinated biphenyl congeners, dichlorodiphenyltrichloroethane, and brominated diphenyl ether congeners, in higher trophic level (TL) organisms are expected to be strongly elevated above those in water. This work compares lipid-based concentrations at equilibrium with the water phase derived from aqueous passive sampling (C L⇌water) with the lipid-based concentrations in fillet and liver of fish (C L) at different TLs for three water bodies in the Czech Republic and Slovakia. The C L values of HOCs in fish were near C L⇌water, only after trophic magnification up to TL = 4. For fish at lower TL, C L progressively decreased relative to C L⇌water as K OW of HOCs increased above 106. The C L value decreasing toward the bottom of the food chain suggests nonequilibrium for primary producers (algae), which is in agreement with modeling passive HOC uptake by algae. Because trophic magnification and the resulting C L in fish exhibit large natural variability, C L⇌water is a viable alternative for monitoring HOCs using fish, showing a twofold lower confidence range and requiring less samples.

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“…The percent increases were highest for congeners that were scarce in the sediment but prominent in the PC (Figure S7). The percent increase (from 1 to 303%) in bulk concentration resulting from amending the historically contaminated MH sediment with PC was much higher than the percent increase for the PS (from 0 to 101%), which has been shown to be a good thermodynamic metric for bioavailability assessment (e.g., Smedes et al 2017).…”

Section: Bioavailability Evaluation Using a Historically Contaminated Sediment Amended With Pcmentioning

confidence: 83%

Passive-Sampler-Based Bioavailability Assessment of PCB Congeners Associated With Aroclor-containing Paint Chips in the Presence of Sediment

Lotufo

Gidley

McQueen

et al. 2021

Preprint

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This is the first investigation of the bioavailability of PCBs associated with paint chips (PC) dispersed in sediment. Bioavailability of PCB-containing PC in sediment was measured using ex situ polyethylene passive samplers (PS) and compared to that of PCBs from field-collected sediments. PC were mixed in freshwater sediment from a site with no known PCB contamination sources and from a contaminated site with non-paint PCB sources. Particles <0.045 mm generated concentrations in the PS over one order of magnitude higher than coarser particles. The bioavailable fraction was represented by the polymer-sediment accumulation factor (PSAF), defined as the ratio of the PCB concentrations in the PS and organic carbon normalized sediment. The PSAF was similar for both field sediments and was ~50-60 and ~ 5 times higher than for the 0.25-0.3 mm and <0.045 mm fractions, respectively, of PC mixed in sediment. These results indicate much lower bioavailability for PCBs associated with PC compared to PCBs associated with field-collected sediment. Such information is essential for risk assessment and remediation decision making for sites where contamination from non-paint PCBs sources are co-located with PCB PC.

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Partitioning of hydrophobic organic contaminants between polymer and lipids for two silicones and low density polyethylene

Cited by 41 publications

References 28 publications

Kinetics of Equilibrium Passive Sampling of Organic Chemicals with Polymers in Diverse Mammalian Tissues

Kinetics of Equilibrium Passive Sampling of Organic Chemicals with Polymers in Diverse Mammalian Tissues

Unraveling the Relationship between the Concentrations of Hydrophobic Organic Contaminants in Freshwater Fish of Different Trophic Levels and Water Using Passive Sampling

Passive-Sampler-Based Bioavailability Assessment of PCB Congeners Associated With Aroclor-containing Paint Chips in the Presence of Sediment

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