Parvalbumin Affects Skeletal Muscle Trophism Through Modulation of Mitochondrial Calcium Uptake

Butera, Gaia; Canato, Marta; Reane, Denis Vecellio; Pietrangelo, Laura; Boncompagni, Simona; Protasi, Feliciano; Rizzuto, Rosario; Reggiani, Carlo; Raffaello, Anna

doi:10.2139/ssrn.3652387

Cited by 4 publications

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“…Intracellular Ca 2+ also modulates muscle contraction. Parvalbumin plays an essential role as a cytosolic Ca 2+ buffer in skeletal muscle fibres (Butera et al, 2021). In this study, we detected an immunoreaction in the smooth muscles of the vessels, epididymal ducts, and seminiferous tubules in all postnatal periods.…”

Section: Discussionmentioning

confidence: 99%

Identification of some calcium binding proteins and neural cell markers in rat testis and epididymis during postnatal development

et al. 2022

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Calcium‐binding proteins (CaBPs) have an essential role in male reproduction by modulating calcium ion metabolism. Although the brain and testis are structurally and functionally different, they show a high degree of transcriptomic and proteomic similarities. The purpose of the present study was to explore some CaBPs (Iba‐1, Calbindin, Calretinin and Parvalbumin) and neural cell markers (CNPase, NG2 and Drebrin) expression in rat testis and epididymis during postnatal periods by using immunohistochemistry. Iba‐1, calbindin, calretinin, parvalbumin, CNPase, NG2 and drebrin were expressed in the epididymal epithelium in each postnatal period. Iba‐1 and calbindin expression showed stage‐dependent expression in spermatids. CaBPs and neural cell markers showed a positive reaction in Leydig cells in the postpubertal and mature periods. Sertoli cells, gonocytes, spermatogonium, and peritubular myoid cells showed heterogeneity in the expression of CaBPs and nerve markers throughout postnatal development. Interestingly, CNPase, NG2 and drebrin were positive in spermatocytes, spermatids, and sperm. Expression dynamics of calcium‐binding proteins and nerve markers showed differences in germ cells and somatic cells during postnatal development. The expression of these proteins in the testis and epididymis supports that they may have important roles in reproductive physiology.

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Section: Discussionmentioning

confidence: 99%

Identification of some calcium binding proteins and neural cell markers in rat testis and epididymis during postnatal development

et al. 2022

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“…Although it's fairly well established that mitochondrial Ca 2+ uptake in cardiomyocytes does not alter [Ca 2+ ] cyt transients or cardiac contractility, there is evidence that mitochondria can modulate [Ca 2+ ] cyt in fast-twitch skeletal muscle fibers under certain conditions (121), a view that is supported by recent evidence Downloaded from http://portlandpress.com/bioscirep/article-pdf/doi/10.1042/BSR20211997/939753/bsr-2021-1997c.pdf by guest on 05 December 2022 indicating that mitochondria in fast-twitch mouse fibers have a high Ca 2+ -buffering capacity (122). A recent paper by Butera and colleagues (2021) highlighted the dynamic relationship between the mitochondria and PV regarding Ca 2+ buffering (123). Butera and collogues reported that when PV was overexpressed, mitochondrial volume and number decrease but when PV was downregulated, the mitochondria increased in size and quantity (123).…”

Section: Calcium Buffering Proteinsmentioning

confidence: 93%

“…A recent paper by Butera and colleagues (2021) highlighted the dynamic relationship between the mitochondria and PV regarding Ca 2+ buffering (123). Butera and collogues reported that when PV was overexpressed, mitochondrial volume and number decrease but when PV was downregulated, the mitochondria increased in size and quantity (123). This alone may not indicate that mitochondria are being upregulated to buffer Ca 2+ but rather mitochondrial biogenesis results from the activation of Ca 2+ dependent signaling pathways in the absence of PV.…”

Section: Calcium Buffering Proteinsmentioning

confidence: 99%

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Skeletal and cardiac muscle calcium transport regulation in health and disease

2022

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In healthy muscle, the rapid release of calcium ions (Ca2+) with excitation-contraction (E-C) coupling, results in elevations in Ca2+ concentrations which can exceed 10-fold that of resting values. The sizable transient changes in Ca2+ concentrations are necessary for the activation of signaling pathways which rely on Ca2+ as a second messenger, including those involved with force generation, fiber type distribution and hypertrophy. However, prolonged elevations in intracellular Ca2+ can result in the unwanted activation of Ca2+ signaling pathways that cause muscle damage, dysfunction, and disease. Muscle employs several calcium handling and calcium transport proteins that function to rapidly return Ca2+ concentrations back to resting levels following contraction. This review will detail our current understanding of calcium handling during the decay phase of intracellular calcium transients in healthy skeletal and cardiac muscle. We will also discuss how impairments in Ca2+ transport can occur and how mishandling of Ca2+ can lead to the pathogenesis and/or progression of skeletal muscle myopathies and cardiomyopathies.

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“…Após a contração muscular, iões Ca 2+ são transportados para o retículo sarcoplasmático através de bombas, canais ou proteínas de transporte (e.g. parvalbumina) (Butera et al 2021).…”

Section: Introductionunclassified

Modulação da alergenicidade em peixes de cultivo

Schrama¹,

Rodrigues²

2022

SEAS

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O peixe é um dos nove alimentos mais alergénicos do mundo, que pode induzir uma resposta imune excessiva a proteínas específicas. A maioria das reações alérgicas a peixe são mediadas por anticorpos IgE e ocorrem poucos minutos após a sua ingestão ou contato. O principal alergénio no peixe é uma proteína pequena e estável do músculo branco que se liga ao cálcio, chamada parvalbumina, a qual é responsável por 70-95% das reações alérgicas. A alteração da expressão/concentração e/ou da estrutura deste alergénio através da suplementação das dietas dos peixes aparenta ser uma estratégia pioneira no ramo da nutrição em peixe e alergenicidade. Resultados promissores mostraram uma redução de 50% na reatividade do IgE em pacientes alérgicos a peixe, quando a apo-forma da parvalbumina, ou seja, a proteína desprovida de iões cálcio, é induzida na dourada.

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Parvalbumin Affects Skeletal Muscle Trophism Through Modulation of Mitochondrial Calcium Uptake

Cited by 4 publications

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Identification of some calcium binding proteins and neural cell markers in rat testis and epididymis during postnatal development

Identification of some calcium binding proteins and neural cell markers in rat testis and epididymis during postnatal development

Skeletal and cardiac muscle calcium transport regulation in health and disease

Modulação da alergenicidade em peixes de cultivo

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