Parvovirus B19 Infection in a Fatal Case of Acute Liver Failure

Leon, Luciane Almeida Amado; Alves, Arthur Daniel Rocha; Garcia, Rita de Cássia Nasser Cubel; Melgaço, Juliana Gil; Paula, Vanessa Salete de; Pinto, Marcelo Alves

doi:10.1097/inf.0000000000001731

Cited by 11 publications

(10 citation statements)

References 15 publications

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“…In the patients with pronounced immune deficiency, one may observe severe non-typical clinical condition affecting liver, kidney, myocardium, central nervous system being at high risk for lethal outcome [3,8,9,10].…”

Section: Discussionmentioning

confidence: 99%

“…Incidence of parvovirus B19 (PVB19) infections is registered everywhere in the world, with specific antibodies detectable in 70-75% of adult population [1,2]. In immunocompetent persons, the PVB19 infection typically manifests as infectious erythema or arthropathy [2,3,4]. In certain cohorts, however, this infection may proceed as a severe disorder, e.g., in hematological patients where it may cause aplastic crisis, in pregnant women, as well as in immunocopromised patients [2,4,5].…”

Section: Introductionmentioning

confidence: 99%

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Haemorrhagic enteritis associated with parvovirus B19 following hematopoietic stem cell transplantation: a case report and literature data

Goloshchapov¹,

Ventslovayte²,

Klementeva³

et al. 2019

CTT

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Parvovirus (PV) B19 infection is rather spread worldwide and manifests with a range of clinical symptoms. The aim of our report was to demonstrate a rare case of haemorrhagic enteritis associated with parvovirus B19 in the patient after allogeneic hematopoietic stem cell transplantation (allo-HSCT).We present here a clinical case of PV infection which proceeded as acute haemorrhagic enteritis in 52-year male patient who underwent HSCT. Distinct expression of antigens specific for PV B19 was revealed on autopsy by means of immunohistochemical testing, along with PVB19 DNA found in stomach, small intestine tissues and myocardial samples by means of PCR technique.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Haemorrhagic enteritis associated with parvovirus B19 following hematopoietic stem cell transplantation: a case report and literature data

Goloshchapov¹,

Ventslovayte²,

Klementeva³

et al. 2019

CTT

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“…As of June 9, 2022, 402 cases have been reported in Europe according to the European Centre for Disease Prevention and Control (ECDC). Cases were reported in the United Kingdom (224), Spain (36), Italy (31), Belgium (14), the Netherlands (14), Portugal (15), Sweden (9), Ireland (13), Poland (8), Denmark (7), France (7), Greece (6), and Norway (5) (4). No cases have been reported in China to date (Figure 3).…”

Section: Global Epidemic Situationmentioning

confidence: 99%

Attention should be paid to acute hepatitis of unknown etiology in children

Guang-bin

2022

IRDR

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adenovirus infection, viral hepatitis, healthy children, acute hepatitis of unknown etiology in children, epidemic Since April 5, 2022, an increase in cases of severe acute hepatitis of unknown etiology among children with no underlying conditions was first reported in the United Kingdom (UK). Testing excluded viral hepatitis types A, B, C, D, and E and other known common and uncommon infectious and non-infectious causes of acute hepatitis. As of May 26, 2022, 650 cases of acute hepatitis of unknown etiology in children have been reported in at least 33 countries worldwide, with 99 additional cases pending classification. Here, the current prevalence of this condition around the world, a hazard analysis, possible causes, the risk of an outbreak in China, and advice on prevention have been briefly reviewed.

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“…During in vivo persistence in non-erythroid tissues, B19V has been reported to express mRNA and protein ( Adamson-Small et al, 2014 ; Bock, 2014 ; Leon et al, 2017 ; Alves et al, 2020 ), whereas evidence of productive virus replication is lacking. In B19V-infected non-permissive cell cultures, VP and NS1 mRNAs may be expressed ( Zakrzewska et al, 2005 ; Ganaie and Qiu, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Prevalence, Cell Tropism, and Clinical Impact of Human Parvovirus Persistence in Adenomatous, Cancerous, Inflamed, and Healthy Intestinal Mucosa

Leskinen

Gritti

et al. 2022

Front. Microbiol.

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Parvoviruses are single-stranded DNA viruses, infecting many animals from insects to humans. Human parvovirus B19 (B19V) causes erythema infectiosum, arthropathy, anemia, and fetal death, and human bocavirus (HBoV) 1 causes respiratory tract infections, while HBoV2-4 are enteric. Parvoviral genomes can persist in diverse non-permissive tissues after acute infection, but the host-cell tropism and the impact of their tissue persistence are poorly studied. We searched for parvoviral DNA in a total of 427 intestinal biopsy specimens, as paired disease-affected and healthy mucosa, obtained from 130 patients with malignancy, ulcerative colitis (UC), or adenomas, and in similar intestinal segments from 55 healthy subjects. Only three (1.6%) individuals exhibited intestinal HBoV DNA (one each of HBoV1, 2, and 3). Conversely, B19V DNA persisted frequently in the intestine, with 50, 47, 31, and 27% detection rates in the patients with malignancy, UC, or adenomas, and in the healthy subjects, respectively. Intra-individually, B19V DNA persisted significantly more often in the healthy intestinal segments than in the inflamed colons of UC patients. The highest loads of B19V DNA were seen in the ileum and colon specimens of two healthy individuals. With dual-RNAscope in situ hybridization and immunohistochemistry assays, we located the B19V persistence sites of these intestines in mucosal B cells of lymphoid follicles and vascular endothelial cells. Viral messenger RNA transcription remained, however, undetected. RNA sequencing (RNA-seq) identified 272 differentially expressed cellular genes between B19V DNA-positive and -negative healthy ileum biopsy specimens. Pathway enrichment analysis revealed that B19V persistence activated the intestinal cell viability and inhibited apoptosis. Lifelong B19V DNA persistence thus modulates host gene expression, which may lead to clinical outcomes.

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Parvovirus B19 Infection in a Fatal Case of Acute Liver Failure

Cited by 11 publications

References 15 publications

Haemorrhagic enteritis associated with parvovirus B19 following hematopoietic stem cell transplantation: a case report and literature data

Haemorrhagic enteritis associated with parvovirus B19 following hematopoietic stem cell transplantation: a case report and literature data

Attention should be paid to acute hepatitis of unknown etiology in children

Prevalence, Cell Tropism, and Clinical Impact of Human Parvovirus Persistence in Adenomatous, Cancerous, Inflamed, and Healthy Intestinal Mucosa

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