1992
DOI: 10.1002/jmv.1890380209
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Passive immunizations of suckling mice and infants with bovine colostrum containing antibodies to human rotavirus

Abstract: After immunizing 8-month pregnant Holstein cows with the human rotavirus MO strain, cow colostrum containing neutralizing antibody to four different serotypes of human rotavirus, designated Rota colostrum, was obtained. Oral inoculation of human rotavirus MO strain into 5-day-old BALB/c mice causes gastroenteritis characterized by diarrhea. Using this small animal model, passive protection of suckling mice against human rotavirus infection was achieved with the use of Rota colostrum. Rota colostrum completely … Show more

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Cited by 61 publications
(40 citation statements)
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“…α-LA and β-LG were present as major components in F3. As mentioned above, IgG was identified as a rotavirus inhibitor in bovine milk (Ebina et al, 1992;Sarker et al, 1998). Accordingly, to address the contribution of IgG to the anti-HRV activity of Dried MFRF, we attempted to separate IgG in each fraction from other components by using affinity chromatography on a HiTrap Protein G HP column (5 ml, GE Healthcare UK Ltd.).…”
Section: Analysis Of the Protective Components In Dried Mfrfmentioning
confidence: 99%
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“…α-LA and β-LG were present as major components in F3. As mentioned above, IgG was identified as a rotavirus inhibitor in bovine milk (Ebina et al, 1992;Sarker et al, 1998). Accordingly, to address the contribution of IgG to the anti-HRV activity of Dried MFRF, we attempted to separate IgG in each fraction from other components by using affinity chromatography on a HiTrap Protein G HP column (5 ml, GE Healthcare UK Ltd.).…”
Section: Analysis Of the Protective Components In Dried Mfrfmentioning
confidence: 99%
“…It has been proposed that passive protection against HRV infection could be achieved by using immunoglobulin G (IgG) from the colostrum of cows hyper-immunized with rotavirus (Ebina et al, 1992;Sarker et al, 1998). Unfortunately, the clinical use of bovine colostrum from hyper-immunized cows has been limited because of difficulties in largescale production.…”
Section: Introductionmentioning
confidence: 99%
“…Not only homologous rotaviruses such as EW, ER and YR-1, but also heterologous strains such as SA11 (G3), MO (G3) and a vaccine candidate strain (e.g., RRV, G3) cause gastroenteritis in newborn mice (6)(7)(8)(9). The conventional method of serotyping is the plaque-or focus-reduction neutralization assay.…”
Section: E2 or Bc5 (G3) St-2g7 Or Be18 (G4) Yo-is3 Ku-6b11 Or Yo-mentioning
confidence: 99%
“…The principal failure of vaccine candidates in field trials has been due to the limited immune response elicited to the antigenic regions relevant to protection of the rotaviruses (5). Passive immune prophylaxis of rotavirus gastroenteritis was proved to be feasible in suckling mice and infants with lyophilized colostral milk from human rotavirus-immunized cows (6). For experiments with active and passive immunity against rotavirus gastroenteritis, a murine model has been employed by using either homologous or heterologous rotaviruses (6)(7)(8)(9).…”
mentioning
confidence: 99%
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