A review of the root causes and mechanisms of damage and failure to wind turbine blades is presented in this paper. In particular, the mechanisms of leading edge erosion, adhesive joint degradation, trailing edge failure, buckling and blade collapse phenomena are considered. Methods of investigation of different damage mechanisms are reviewed, including full scale testing, post-mortem analysis, incident reports, computational simulations and sub-component testing. The most endangered regions of blades include the protruding parts (tip, leading edges), tapered and transitional areas and bond lines/adhesives. Computational models of different blade damage mechanisms are discussed. The role of manufacturing defects (voids, debonding, waviness, other deviations) for the failure mechanisms of wind turbine blades is highlighted. It is concluded that the strength and durability of wind turbine blades is controlled to a large degree by the strength of adhesive joints, interfaces and thin layers (interlaminar layers, adhesives) in the blade. Possible solutions to mitigate various blade damage mechanisms are discussed.