Passive Transport of Ionic Drugs through Membranes with pH-Dependent Fixed Charges

Jimbo, Toshihiko; Ramı́rez, Patricio; Tanioka, Akihiko; Mafé, Salvador; Minoura, Norihiko

doi:10.1006/jcis.2000.6779

Cited by 41 publications

(36 citation statements)

References 18 publications

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“…Thus, the wall thickness of the HSA/DMPA microcapsules, that is, the number of HSA/DMPA layers, will also influence the release rate. This can be quantified by calculating the permeability coefficient (P) by using Equation (1), [11] P ¼ ðDc t =DtÞVd Sðc 0 ÀctÞ ð1Þ in which P (cm 2 s À1 ) is the permeability coefficient of the capsule membrane, S is the effective surface area of the dispersed capsules, d (cm) is the thickness of the capsule wall, V is the volume of the bulk solution, Dc t /Dt is the concentration change per unit time, which can be evaluated from the derivative of the fractional release curve, and c t and c 0 are the drug concentrations in the bulk solution and within the capsules, respectively. We assumed that 1) the microcapsules were cubic, with a mean size of 15 15 15 mm 3 , 2) c 0 was equal to the saturation solubility of ibuprofen in the buffer solution, and 3) the average thickness of an HSA/DMPA capsule was 10 nm (as confirmed by the single-particle light scattering experiment [12] ).…”

Section: Resultsmentioning

confidence: 99%

Self‐Assembly of Human Serum Albumin (HSA) and l‐α‐Dimyristoylphosphatidic Acid (DMPA) Microcapsules for Controlled Drug Release

An¹,

Lü²,

Möhwald³

et al. 2004

Chemistry A European J

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Human serum albumin (HSA) and L-alpha-dimyristoylphosphatidic acid (DMPA) were applied as a pair to encapsulate ibuprofen microcrystals by means of a technique based on the layer-by-layer (LbL) assembly of oppositely charged species, for the purpose of controlling drug release. The successful adsorption of HSA and DMPA multilayers onto ibuprofen crystals was confirmed by optical microscopy. The drug release process, in a solution of pH 7.4, was monitored by optical microscopy and UV spectroscopy. The results revealed that the rate of release of ibuprofen from HSA/DMPA microcapsules decreased as the capsule wall thickness and drug crystal size increased, indicating that the permeability of the microcapsules can be controlled by simply varying the number of HSA/DMPA deposition cycles.

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Section: Resultsmentioning

confidence: 99%

Self‐Assembly of Human Serum Albumin (HSA) and l‐α‐Dimyristoylphosphatidic Acid (DMPA) Microcapsules for Controlled Drug Release

An¹,

Lü²,

Möhwald³

et al. 2004

Chemistry A European J

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“…Protein adsorption on membranes not only could change the pore size and charge property of the membrane but also could give valuable information for the study of the protein transport mechanism within the membrane. 6,11,12 There have been, however, few reports on the relationship between insulin adsorption on and transport through a membrane for the drug delivery. It is of great interest to study the insulin adsorption behavior on the charged membranes for the administration of insulin release.…”

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confidence: 99%

“…11,[13][14][15][16] In the present study, a series of amphoteric charged membranes with different ratios of acidic to basic groups were prepared, and the insulin adsorption on the prepared membranes was investigated at different pHs. The aim of this study is to investigate the relationship between the insulin adsorption behavior and the surface charge property of the amphoteric charged membranes for drug delivery.…”

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Characterization of Insulin Adsorption Behavior on Amphoteric Charged Membranes

Zhang

Saito

Matsumoto

et al. 2008

Polym J

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With view to develop an amphoteric charged membrane for drug delivery, we have studied the adsorption of insulin on it. In the present study, the amphoteric charged membranes were prepared by pore-surface modification of porous poly(acrylonitrile) (PAN) membranes by grafting with acrylic acid (AAc) and/or N,N-(dimethylamino)propyl acrylamide (DMAPAA). Their surface charge properties and the insulin adsorption behaviors were investigated by zeta potential measurement and UV spectrophotoscopy, respectively, at different pHs. The equilibrium adsorbed amount of insulin correlates well with the charge properties of the membranes and insulin, which indicates that electrostatic interaction played an important role in the insulin adsorption. In addition, adsorption kinetics changed from a Fickian mode to a non-Fickian one when adsorbed amount increased to very high values.KEY WORDS: Insulin / Poly(acrylonitrile) / Amphoteric Charged Membrane / Zeta Potential / Adsorption / Insulin is a polypeptide hormone produced by the pancreatic cells, and regulates carbohydrate homeostasis. Currently, the administration of insulin through parenteral injection (e.g., subcutaneous injection) is the commonest therapy of diabetes. Since pain and risk for infection cannot be completely avoided in this method, novel non-invasive insulin delivery techniques such as iontophoresis have been required.

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“…38 Therefore, there is still a lot of work to do for the quantitative description of the diffusion of insulin through the porous charged membranes.…”

Section: Comparison Of the Experimental And Estimated Pmentioning

confidence: 99%

Insulin transport across porous charged membranes: Effect of the electrostatic interaction

Zhang¹,

Matsumoto²,

Saito³

et al. 2009

Biotechnology Progress

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Insulin transport phenomena across a series of porous charged membranes were studied at two pH conditions (pH 3.3 and pH 7.4) in this article. The membranes were prepared by pore-surface modification of porous poly(acrylonitrile) (PAN) membranes by grafting with weak acidic and basic functional groups. The insulin partition coefficient K between the membrane and solution was estimated from the equilibrium adsorption amount in the batch adsorption experiment. The insulin effective diffusion coefficient D inside the membrane was determined as a fitting parameter by matching the diffusion model with the experimental data of the diffusion measurement. Both K and D correlated well with the charge properties of the insulin and membrane: when the insulin and membrane carried opposite net charge, the partition coefficient showed relatively larger values, while the effective diffusion coefficient was reduced. The insulin permeability coefficient P obtained from the experimental results agreed with that estimated from the partition coefficient and effective diffusion coefficient. These results suggested that the combined effects of the solubility and diffusivity on the permeability coefficient complicated the relationship between the permeability and the charge properties of the insulin and membrane. Additionally, our calculation supported that insulin permeability was reduced by the boundary layer between the membrane and solution.

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Passive Transport of Ionic Drugs through Membranes with pH-Dependent Fixed Charges

Cited by 41 publications

References 18 publications

Self‐Assembly of Human Serum Albumin (HSA) and l‐α‐Dimyristoylphosphatidic Acid (DMPA) Microcapsules for Controlled Drug Release

Self‐Assembly of Human Serum Albumin (HSA) and l‐α‐Dimyristoylphosphatidic Acid (DMPA) Microcapsules for Controlled Drug Release

Characterization of Insulin Adsorption Behavior on Amphoteric Charged Membranes

Insulin transport across porous charged membranes: Effect of the electrostatic interaction

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