Past Decade Work Done on Cubosomes and its Factorial Design: A Fast Track Information for Researchers

Shravani, Y; Ahad, Hindustan Abdul; Chinthaginjala, Haranath; Poojitha, Bhumireddy gari; Rahamathulla, Syed; Rupasree, Aswarthanarayana

doi:10.22376/ijpbs/lpr.2021.11.1.p124-135

Cited by 19 publications

(10 citation statements)

References 46 publications

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“…Overall, the system embraces setting up an evolution of provisions, hence shifting the groupings of the describe activity in some effectual way. In this, the authors adopted a central composite design for optimization [6,7].…”

Section: Optimized Rapid Disintegrating Tablets Produced Through Cent...mentioning

confidence: 99%

Optimized Rapid Disintegrating Tablets produced through Central Composite Design

Ahad¹,

Chinthaginjala²,

Reddy³

et al. 2022

Current Issues in Pharmacy and Medical Sciences

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The work is aimed at producing fast disintegrating diclofenac potassium tablets to relieve pain and tenderness by applying a quality-by-design approach. Diclofenac potassium (DP) is of BCS class II and has issues of minimal oral bioavailability. This can be overcome by complexing DP with β-cyclodextrin (β-CD) and sodium starch glycolate (SSG). The attempt was to optimize DP tablets by applying central composite design (CCD). Nine different DP tablet formulations were created and assessed for physicochemical constraints, disintegration time and drug dissolution at the end of 30 min. The separate and mutual consequences of β-CD and SSG on the disintegration time of DP tablets are highly significant (P<0.01). The DP tablets made with β-CD in 150 mg disintegrated rapidly within 39±2 sec, and gave very rapid drug dissolution (96.35±2.36%) at the end of 30 min. These DP tablets (F-8) contain β-CD (150 mg) and SSG at 32.07 mg. The intermittent levels of β-CD and higher levels of SSG gave good dissolution of DP tablets. The polynomial equation linking the response, i.e. disintegration time in sec (Y1) and the levels of β-CD (A) and SSG (B) based on the pragmatic results, is Y1=45-3.14277A- 2.46599B-1.25AB+1.75A2-0.5B2. In contrast, the DP release at the end of 30 min was expressed as Y2 = 88.57 + 4.09333A + 3.27837B + 1.2525AB - 2A2 + 0.8875B2. The study concludes that SSG decreases the disintegration time with its concentration and β-CD concentration ingresses the drug release from the formulation.

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Section: Optimized Rapid Disintegrating Tablets Produced Through Cent...mentioning

confidence: 99%

Optimized Rapid Disintegrating Tablets produced through Central Composite Design

Ahad¹,

Chinthaginjala²,

Reddy³

et al. 2022

Current Issues in Pharmacy and Medical Sciences

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“…The microspheres remain in the stomach and liberate the drug by binding with gastric mucosa [13,14].…”

Section: Mucoadhesive Microspheresmentioning

confidence: 99%

Past Decade Attempts on Gastro Retentive Microspheres Using Factorial Design: A Comprehensive Literature

Mundarinti¹,

Ahad²

2021

Int j pharm phytopharm res

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The main intention of floating microspheres is to elevate gastro-retentive time, there by drug release and bioavailability. Floating drug delivery systems glide on gastric fluid for an extended time without leaving the stomach and give good accessibility of the drug systemically and good duration of action for the prolonged period of time. Gastro-retentive microspheres are preferred for local action, local absorption, and preventing drug deterioration at the stomach. This article was made by pearly referring to published research papers of both online and offline journals on gastro retentive microspheres made by factorial design. The authors succeeded in collecting the information about the past decade of work done on gastro retentive drug delivery systems using factorial design. The authors from this study conclude that factorial design is an appreciable technique in the optimization of the gastro retentive dosage form in the form off microspheres for the drug delivery for the extended period of time.

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“…It will result in inaccurate results because these factors are interconnected. Multivariate analysis depends heavily on the design of experiments (DOE) [14,15]. Partially determinable factors are included in the DOE.…”

Section: Introductionmentioning

confidence: 99%

Plant Gum Aided Mucoadhesive Microspheres to Eradicate Helicobacter pylori and Its Optimization with Design-Expert's Central Composite Design

Mundarinti¹,

Ahad²

2022

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Aim: The aim of the work was to explore the mucoadhesive properties of Mastic gum by involving it in mucoadhesive microspheres with Amoxicillin Trihydrate as a model drug. Using Carbopol-934P and varying amounts of Mastic gum. Methods: 9 interpretations of mucoadhesive microspheres were made by using Design expert software. A central composite design was applied to test the impact of independent variables (Carbopol-934P and mastic gum levels) on drug released at 10h and mucoadhesive strength as the response. Results: A congeniality and physical exam was conducted on the microspheres to see if Amoxicillin Trihydrate (ATH) was present, including its liberation. In formulations that contain lower levels of MG, mucoadhesion strength increased and drug released at the end of 10h was greater. Conclusion: Since MG acts as a release retardant, the amount of drug released is slightly reduced when higher levels are present in formulations. ATH gastro retention for eradicating with Mastic gum aided mucoadhesion (as this gum is proven H. pylori activity) is capable of completely capturing the gastrointestinal tract and effectively delivering the medication to the stomach.

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Past Decade Work Done on Cubosomes and its Factorial Design: A Fast Track Information for Researchers

Cited by 19 publications

References 46 publications

Optimized Rapid Disintegrating Tablets produced through Central Composite Design

Optimized Rapid Disintegrating Tablets produced through Central Composite Design

Past Decade Attempts on Gastro Retentive Microspheres Using Factorial Design: A Comprehensive Literature

Plant Gum Aided Mucoadhesive Microspheres to Eradicate Helicobacter pylori and Its Optimization with Design-Expert's Central Composite Design

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