Past, present and future of cocaine- and amphetamine-regulated transcript peptide

Yosten, Gina L. C.; Haddock, Christopher J.; Harada, Caron M.; Almeida-Pereira, Gislaine; Kolar, Grant R.; Stein, Lauren M.; Hayes, Matthew R.; Salvemini, Daniela; Samson, Willis K.

doi:10.1016/j.physbeh.2021.113380

Cited by 11 publications

(8 citation statements)

References 61 publications

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“…But it became evident that it was involved in many additional physiological processes including body weight and feeding, energy expenditure, physical activity, body temperature, endocrine regulation, drug abuse and reward, pain, stress, hypertension, anxiety and depression, recovery from stroke, and possibly others. There are many reviews and other citations describing the evidence for these effects [ 5 – 30 ]. The general belief was and is that CARTp is an important peptide neurotransmitter.…”

Section: Introductionmentioning

confidence: 99%

Commentary: GPR160 De-Orphanization Reveals Critical Roles in Neuropathic Pain in Rodents (Finally, a Receptor for CART Peptide)

Job¹,

Kuhar²

2021

Adv. Drug Alcohol Res.

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Section: Introductionmentioning

confidence: 99%

Commentary: GPR160 De-Orphanization Reveals Critical Roles in Neuropathic Pain in Rodents (Finally, a Receptor for CART Peptide)

Job¹,

Kuhar²

2021

Adv. Drug Alcohol Res.

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“…(1) No effect of CARTPT on the association of IGF-1 serum level and BC risk. (2) No association between IGF-1 serum level and CARTPT. (3) GG genotype of CARTPT rs3846659 SNP increased the risk of BC in the group of patients with IGFBP-3 serum level in the highest tertile.…”

mentioning

confidence: 99%

The Role of Cocaine- and Amphetamine-Regulated Transcript (CART) in Cancer: A Systematic Review

Owe-Larsson,

Pawłasek,

Piecha

et al. 2023

IJMS

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The functions of cocaine- and amphetamine-regulated transcript (CART) neuropeptide encoded by the CARTPT gene vary from modifying behavior and pain sensitivity to being an antioxidant. Putative CART peptide receptor GPR160 was implicated recently in the pathogenesis of cancer. However, the exact role of CART protein in the development of neoplasms remains unclear. This systematic review includes articles retrieved from the Scopus, PubMed, Web of Science and Medline Complete databases. Nineteen publications that met the inclusion criteria and describe the association of CART and cancer were analyzed. CART is expressed in various types of cancer, e.g., in breast cancer and neuroendocrine tumors (NETs). The role of CART as a potential biomarker in breast cancer, stomach adenocarcinoma, glioma and some types of NETs was suggested. In various cancer cell lines, CARTPT acts an oncogene, enhancing cellular survival by the activation of the ERK pathway, the stimulation of other pro-survival molecules, the inhibition of apoptosis or the increase in cyclin D1 levels. In breast cancer, CART was reported to protect tumor cells from tamoxifen-mediated death. Taken together, these data support the role of CART activity in the pathogenesis of cancer, thus opening new diagnostic and therapeutic approaches in neoplastic disorders.

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“…Попытки поиска альтернативных способов лабораторного выделения данного пептида продолжались в течение следующих 14 лет. Наконец в 1995 г. в ходе эксперимента с моделированием наркотической зависимости у лабораторных мышей удалось выделить специфичный ген CARTPT (Cocaine and amphetamine-regulated transcript prepropeptide gene), что было зафиксировано в мартовском номере журнала Journal of Neuroscience (CША) [ 4 ]. Авторский коллектив вышеуказанной статьи состоял из представителей американского и австралийского научного сообщества: Oregon Health & Science University (США), Chicago Medical School (США), The University of Sydney (Австралия) Portland [ 3 ].…”

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“…Таким образом, первый день весны 1995 г. ознаменовал начало новой эры в изучении гипоталамо-гипофизарного звена эндокринной системы. Описанный в статье эксперимент заключался в анализе экспрессии мРНК в ответ на введение различных психостимуляторов (кокаин, амфетамин) в организм лабораторных мышей, что привело к повышению уровня экспрессии КАРТ совместно с другим нейромедиатором — проопиомеланокортином (ПОМК) [ 4 ]. Экспрессия КАРТ была экспериментально отмечена в различных образованиях ЦНС: гипоталамусе, гиппокампе, полосатом теле.…”

unclassified

Cocaine-amphetamine regulated transcript (CART) — promising omics breakthrough in the endocrinology

Михеев¹,

Романцова

Troshina³

et al. 2022

Probl Endokrinol (Mosk)

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BACKGROUND: The cocaine-amphetamine regulated transcript has been discovered long time ago (circa over 25 years ago) but still stays not enough investigated. Just during last five years scientist’s society started providing interest to the genomic, proteomic and metabolic essence of the cocaine-amphetamine regulated transcript.AIM: The evaluation of historical pathway and perspectives of the cocaine-amphetamine regulated transcript medical investigations.MATERIALS AND METHODS: The literature search has been provided via Russian (eLibrary, CyberLeninka.ru) and international (PubMed, Cochrane Library) databases and among articles on Russian and English languages. The main criteria for article selection was free access and 2019–2021 years of publishing. Although the introduction is based on the articles published in 1989. The present article was created according to the federal project «Central and peripheral pathophysiological mechanisms of adipose tissue diseases and their clinical and hormonal manifestations» (2020–2022)RESULTS AND CONCLUISON: It is necessary to keep on investigating genomic, proteomic and metabolomic markers because they contain important clues for successful resistance against human diseases. The 21st century is the era of transformation from simple clinical medicine to personalized science. For example, researches in the area of cocaine-amphetamine regulated transcript may result in invention of genetic medicine against dangerous metabolic diseases.

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Past, present and future of cocaine- and amphetamine-regulated transcript peptide

Cited by 11 publications

References 61 publications

Commentary: GPR160 De-Orphanization Reveals Critical Roles in Neuropathic Pain in Rodents (Finally, a Receptor for CART Peptide)

Commentary: GPR160 De-Orphanization Reveals Critical Roles in Neuropathic Pain in Rodents (Finally, a Receptor for CART Peptide)

The Role of Cocaine- and Amphetamine-Regulated Transcript (CART) in Cancer: A Systematic Review

Cocaine-amphetamine regulated transcript (CART) — promising omics breakthrough in the endocrinology

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