The features of the industrial reproduction of sterlet in the Middle Volga region are considered. The necessity of further increasing the volume of production and release of juvenile sterlet to the Kuibyshev reservoir is shown. An increase in the relevance of research works in the field of sturgeon ichthyopathology has been noted. The importance of carrying out ichthyopathological observations is shown both for ensuring the stability and efficiency of production, and for preserving the natural population of sterlet in the Kuibyshev reservoir. The article considers the relative novelty of ichthyopathology as a science and the discrepancy between normative legal acts regulating ichthyopathological observations in Russia. The industrialization of aquaculture forms is shown. The emergence of new sturgeon diseases specific to high-intensity fish farming was noted. The results of experiments on the use of inorganic drugs for the treatment of sturgeon nutritional diseases are presented.