Patchouli alcohol, an essential oil of Pogostemon cablin, exhibits anti-tumorigenic activity in human colorectal cancer cells

Jeong, Jin Boo; Choi, Jieun; Lou, Zhidong; Jiang, Xiaojing; Lee, Seong-Ho

doi:10.1016/j.intimp.2013.04.006

Cited by 100 publications

(69 citation statements)

References 42 publications

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“…Patchouli alcohol decreases cell growth in MCF7, BxPC3, PC3, and HUVEC cells and downregulates histone deacetylase HDAC2 in human colorectal cancer cells [275]. HDAC2 is a valproate target also forming a complex with the Rett syndrome gene MECP2 [276,277].…”

Section: Cosmetic Ingredients Targeting Autism Genesmentioning

confidence: 99%

Autism genes are selectively targeted by environmental pollutants including pesticides, heavy metals, bisphenol A, phthalates and many others in food, cosmetics or household products

Carter

Blizard

2016

Neurochemistry International

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Section: Cosmetic Ingredients Targeting Autism Genesmentioning

confidence: 99%

Autism genes are selectively targeted by environmental pollutants including pesticides, heavy metals, bisphenol A, phthalates and many others in food, cosmetics or household products

Carter

Blizard

2016

Neurochemistry International

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“…Expression and biological activity of HDAC2 (histone deacetylase 2) were also remarkably repressed. NFKB was active in treated cancer cells as evidenced by an increase in nuclear translocation of p65 (Jeong et al, 2013). Cyclin D1 and CDK4 were also substantially reduced in pancreatic cancer cells after treatment with Frankincense essential oil.…”

Section: In-vitro Analysis Of Different Essential Oilsmentioning

confidence: 96%

Anticancer Activity of Essential Oils: Targeting of Protein Networks in Cancer Cells

Aras

Iqbal²,

Naqvi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…There are reports detailing individual properties of this plant's essential oils such as antimicrobial [10,11], antioxidant [12], analgesic [13], anti-inflammatory [14], antimutagenic [15], antithrombotic [16], antiemetic [17], and cytotoxic activities [18,19]. However, there are no reports which have studied the relationship between the antimicrobial and antioxidant activities of leaf extracts by using traditional extraction methods.…”

Section: Journal Of Botanymentioning

confidence: 99%

Antioxidant and Antimicrobial Activities ofPogostemon cablin(Blanco) Benth.

et al. 2017

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Pogostemon cablin (Lamiaceae) has been widely used in traditional medicine. In this study, the antioxidant and antimicrobial activities of leaves from P. cablin extracts were investigated. The water extracts had the highest total phenolic content 116.88±0.48 mg gallic acid equivalent/g of dry plant extract. Nevertheless, high levels of total flavonoid content were found in ethanolic extracts 280.12 ± 2.04 mg quercetin equivalent/g of dry plant extract. The highest antioxidant activities were found for the ethanolic extract (IC 50 = 18 ± 0.90, 20 ± 0.24 g/mL) by DPPH and ABTS scavenging assays, respectively. Both extracts showed moderate inhibition of superoxide inhibition (O 2•− ) and nitric oxide (NO) production in concentration-dependent manner. Antibacterial activity was calculated by disk diffusion, minimum inhibitory concentration (MIC), and minimum bacterial concentration (MBC). The ethanolic extract had the greatest activity against methicillin resistant Staphylococcus aureus, methicillin sensitive S. aureus, and Streptococcus pyogenes with zone diameters of 11.67 ± 1.53, 10.33 ± 2.52, and 10.33 ± 1.15 mm, respectively. The corresponding MIC and MBCs were 5, 0.625, and 0.039 mg/mL. P. cablin extracts contain antioxidant and antibacterial properties that should be exploited for possible clinical application.

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Patchouli alcohol, an essential oil of Pogostemon cablin, exhibits anti-tumorigenic activity in human colorectal cancer cells

Cited by 100 publications

References 42 publications

Autism genes are selectively targeted by environmental pollutants including pesticides, heavy metals, bisphenol A, phthalates and many others in food, cosmetics or household products

Autism genes are selectively targeted by environmental pollutants including pesticides, heavy metals, bisphenol A, phthalates and many others in food, cosmetics or household products

Anticancer Activity of Essential Oils: Targeting of Protein Networks in Cancer Cells

Antioxidant and Antimicrobial Activities ofPogostemon cablin(Blanco) Benth.

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