Patchouli alcohol protects against lipopolysaccharide-induced acute lung injury in mice

Yu, Jinlong; Zhang, Xiaoshi; Xue, Xindong; Wang, Rong-Mei

doi:10.1016/j.jss.2014.10.026

Cited by 32 publications

(21 citation statements)

References 23 publications

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“…It has been reported that patchouli alcohol has various pharmacological activities, including anti-oxidation by inhibiting ROS accumulation 57 and inammation via suppressing NF-kB signaling pathway. 58,59 Based on the hepatoprotection of PO, we speculate that patchouli alcohol might act as the main active ingredient to play a protective role in liver injury. As a result, we will keep on exploring this active component of PO on ethanolinduced hepatic damage in future study.…”

Section: Discussionmentioning

confidence: 98%

Patchouli oil isolated from the leaves of Pogostemon cablin ameliorates ethanol-induced acute liver injury in rats via inhibition of oxidative stress and lipid accumulation

Huang

Chen

et al. 2018

RSC Adv.

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Section: Discussionmentioning

confidence: 98%

Patchouli oil isolated from the leaves of Pogostemon cablin ameliorates ethanol-induced acute liver injury in rats via inhibition of oxidative stress and lipid accumulation

Huang

Chen

et al. 2018

RSC Adv.

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“…PA is used for the quality control objective of patchouli oil in pharmaceutical industry (The Pharmacopoeia Commission of PRC 2010). Accumulating reports have demonstrated that PA had multiple effects such as anti-inflammatory [7, 8], antivirus [9–12], antimicrobial [13–17], and insecticidal [18, 19], protective effect on fluidity of intestinal epithelial cells [20], protective effect on acute lung injury [21], radical-scavenging activity [22], inhibitory activity on platelet-activating factor (PAF) activation [23], and antiemetic activity [24]. …”

Section: Introductionmentioning

confidence: 99%

Molecular Role of EGFR-MAPK Pathway in Patchouli Alcohol-Induced Apoptosis and Cell Cycle Arrest on A549 CellsIn VitroandIn Vivo

Yang

et al. 2016

BioMed Research International

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Nowadays, chemotherapy is still the main effective treatment for cancer. Herb prescriptions containing Pogostemon cablin Benth (also known as “Guang-Huo-Xiang”) have been widely used in Chinese medicine today. In our research, we found that patchouli alcohol, a compound isolated from the oil of Pogostemon cablin Benth, exerted antitumor ability against human lung cancer A549 cells ability both in vitro and in vivo. MTT assay was used to assess cell viability. Hoechst 33342 staining and TUNEL cover glass staining provided the visual evidence of apoptosis. Caspase activity measurement showed that patchouli alcohol activated caspase 9 and caspase 3 of mitochondria-mediated apoptosis. Consistently, patchouli alcohol inhibited the xenograft tumor in vivo. Further investigation of the underlying molecular mechanism showed that MAPK and EGFR pathway might contribute to the antitumor effect of patchouli alcohol. Our study proved that patchouli alcohol might be able to serve as a novel antitumor compound in the clinical treatment of lung cancer.

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“…According to GC-MS analysis, the most abundant ingredient is patchouli alcohol, with a content of 34.3 %. It has been revealed that patchouli alcohol does a variety of pharmacological activities including anti-oxidation, anti-inflammatory, and antilipogenesis [11,28,29], and these activities are associated with the treatment of NAFLD. Thus, the effect of PO against NAFLD might be related to the content of patchouli alcohol in PO, and patchouli alcohol might act as the main active ingredient.…”

Section: Discussionmentioning

confidence: 99%

Patchouli Oil Attenuates High Fat Diet-induced Non-alcoholic Hepatic Steatosis

Luo

et al. 2020

Planta Med

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Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. Nevertheless, no first-line therapy exists. Hepatic steatosis is the earliest stage of NAFLD, which is characterized by an accumulation of hepatic lipids. Patchouli oil (PO), which is isolated from the well-known Chinese herb named Pogostemon cablin (Blanco) Benth. (Lamiaceae), inhibits hepatic lipid accumulation effectively. However, its potential ability for the treatment of NAFLD had not been reported before. Thus, the objective of this study was to investigate the effectiveness of PO against hepatic steatosis and its underlying mechanisms. We used a high fat diet (HFD)-induced hepatic steatosis model of rats to estimate the effect of PO against NAFLD. Hematoxylin-eosin and oil red O staining were used to analyze the hepatic histopathological changes. ELISA, RT-qPCR, and Western blotting analysis were applied to evaluate the parameters for hepatic steatosis. Our results showed that PO significantly attenuated the lipid profiles and the serum enzymes, evidenced by quantitative and histopathological analyses. It also markedly down-regulated the expression of sterol regulatory element-binding protein 1 (SREPB-1c) with its downstream factors in de novo lipogenesis. And, likewise, in lipid export by very low-density lipoproteins (VLDL), related molecules were dramatically improved. Furthermore, PO observably normalized the aberrant peroxisome proliferator-activated receptor α (PPAR-α) signal in fatty acids oxidation. In conclusion, PO exerted a preventing effect against HFD-induced steatosis and might be due to decrease de novo lipogenesis, promote export of lipids, as well as owing to improve fatty acids oxidation.

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Patchouli alcohol protects against lipopolysaccharide-induced acute lung injury in mice

Cited by 32 publications

References 23 publications

Patchouli oil isolated from the leaves of Pogostemon cablin ameliorates ethanol-induced acute liver injury in rats via inhibition of oxidative stress and lipid accumulation

Patchouli oil isolated from the leaves of Pogostemon cablin ameliorates ethanol-induced acute liver injury in rats via inhibition of oxidative stress and lipid accumulation

Molecular Role of EGFR-MAPK Pathway in Patchouli Alcohol-Induced Apoptosis and Cell Cycle Arrest on A549 CellsIn VitroandIn Vivo

Patchouli Oil Attenuates High Fat Diet-induced Non-alcoholic Hepatic Steatosis

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