Patchouli alcohol protects against myocardial ischaemia–reperfusion injury by regulating the Notch1/Hes1 pathway

Patchouli Alcohol Protects the Heart against Diabetes-Related Cardiomyopathy through the JAK2/STAT3 Signaling Pathway

“…To delve into the potential therapeutic effects of PatA, the mice were categorically divided into four distinct experimental groups (each comprising at least 6 mice): control (Ctrl), STZ-induced T1DM, STZ-induced T1DM mice administered with 5 mg/kg of PatA, and STZ-induced T1DM mice treated with 15 mg/kg of PatA [20,49]. Mice with diabetes were orally given PatA at two dose levels of 5 mg/kg (n = 6) and 15 mg/kg (n = 6) daily, while untreated diabetic control mice were administered the 1% CMC-Na vehicle (n = 6) instead.…”

The effects of patchouli alcohol and combination with cisplatin on proliferation, apoptosis and migration in B16F10 melanoma cells

“… 16 , 17 , 18 Patchouli alcohol (PA), a tricyclic sesquiterpene, is considered a major effective component of P. cablin and is used in the quality control of patchouli oil in the pharmaceutical industry. Several studies have demonstrated that PA has multiple effects, such as anti‐oxidation, 19 anti‐inflammatory, 20 anti‐influenza virus, 21 prevention of UV‐induced skin photoaging, 22 improvement of wound healing, 23 protection against myocardial ischaemia‐reperfusion injury 24 and anti‐tumorigenic activity in colorectal, lung and prostate cancer. 25 , 26 , 27 However, despite these diverse beneficial effects, studies on the use of PA in the treatment of melanoma are lacking.…”