Paternal age and common mental disorders

Krishnaswamy, Saroja; Subramaniam, Kavitha; Indran, Haymanth; Ramachandran, P. Veeraraghavan; Indran, Tishya; Indran, Ramesh; Aziz, Jemain Abdul

doi:10.1080/15622970802653691

Cited by 14 publications

(10 citation statements)

References 22 publications

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“…For the affective disorders the evidence for paternal age as a risk factor is less pronounced. We found only one study to describe a U-shaped relationship as we found for MDD (Krishnaswamy et al , 2009). However, this study describes the relation between younger and older fathers with increased rate of common mental disorders.…”

Section: 4 Discussionmentioning

confidence: 80%

Paternal age and psychiatric disorders: Findings from a Dutch population registry

Buizer-Voskamp

Laan

Staal

et al. 2011

Schizophrenia Research

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Background We measured the association between paternal age and schizophrenia (SCZ), autism spectrum disorders (ASD), major depressive disorder (MDD), and bipolar disorder (BPD) in the Dutch population. Methods In total, 14 231 patients and 56 924 matched controls were collected and analysed for an association with paternal age by logistic regression. Results ASD is significantly associated with increased paternal age: Older fathers >40 years of age have a 3.3 times increased odds of having a child with ASD compared to young fathers <20 years of age. SCZ has significant associations for fathers aged >35 years (OR=1.27, 95% Confidence Interval: 1.05, 1.53). For MDD, both younger and older fathers have increased odds. No association was found for BPD. Conclusions The effects of paternal age as a risk factor are different for ASD and SCZ on one hand, and the affective disorders on the other hand. Different types of association might indicate different biological or psychosocial mechanisms. Late paternity (associated with predispositions to psychiatric disorders) seems the most probable explanation for the association with paternal age.

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Section: 4 Discussionmentioning

confidence: 80%

Paternal age and psychiatric disorders: Findings from a Dutch population registry

Buizer-Voskamp

Laan

Staal

et al. 2011

Schizophrenia Research

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“…[14][15][16][17][18][19][20][21] One study found an association between paternal depression and excessive infant crying. 45 Another study found that children aged 9 to 24 months with depressed fathers are more likely to show speech and language delays, 19,21 whereas another study reported that children aged 2 years with depressed fathers tended to be less compliant with parental guidance.…”

Section: Figurementioning

confidence: 99%

“…26 However, studies investigating paternal mental health outside the newborn period have tended to use small and often atypical samples from which it is difficult to generalize to the population at large, although they too tend to suggest a similar association between fathers' mental health and child outcomes. [14][15][16][17][18][19][20][21][22][23][24][25] Given that mothers spend substantially more time in direct interaction with their children than do fathers, it seems reasonable to hypothesize that maternal mental health problems would be associated with higher rates of children's emotional or behavioral problems than paternal mental health problems would be. Similarly, the literature on the high concordance between mothers' and fathers' mental health and the transmission of depression within families might suggest that mental health problems in general, and depression in particular, when occurring in both mothers and fathers in the same family, is associated with even higher rates of child emotional or behavioral problems.…”

mentioning

confidence: 99%

“…[6][7][8][9][10][11][12] In stark contrast, there is a paucity of literature regarding the association between paternal depression and other mental health problems and child health and functioning. [13][14][15][16][17][18][19][20][21][22][23][24][25] The limited amount of research literature that does exist focuses, in large part, on postpartum paternal depression, suggesting an association between postpartum paternal depression and poor childhood outcomes. 26 However, studies investigating paternal mental health outside the newborn period have tended to use small and often atypical samples from which it is difficult to generalize to the population at large, although they too tend to suggest a similar association between fathers' mental health and child outcomes.…”

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confidence: 99%

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Paternal Depressive Symptoms and Child Behavioral or Emotional Problems in the United States

2011

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WHAT'S KNOWN ON THIS SUBJECT:Much is known about the effects of maternal depression on child health and function. In stark contrast, virtually nothing is known about the association of paternal mental health problems and depression and child functioning. WHAT THIS STUDY ADDS:This study revealed an independent association between fathers' mental health problems and depressive symptoms and increased rates of child emotional and behavioral problems among a large nationally representative sample of children in the United States.abstract BACKGROUND: The negative effects of maternal mental health problems on child health are well documented. In contrast, there is a profound paucity of information about paternal mental health's association with child health. OBJECTIVE:To investigate the association of paternal mental health problems and depressive symptoms and children's emotional or behavioral problems. METHODS:We analyzed Medical Expenditure Panel Survey data, which included a representative sample of US children (N ϭ 21 993) aged 5 to 17 years and their mothers and fathers. The main outcome measure was child emotional or behavioral problems assessed by using the Columbia Impairment Scale. RESULTS:Paternal depressive symptoms, as assessed using the Patient Health Questionnaire-2, and mental health problems, more generally, assessed by using the Short-Form 12 Scale, were independently associated with increased rates of child emotional or behavioral problems even after controlling for numerous potential confounders including maternal depressive symptoms and other mental health problems. The adjusted odds ratio (aOR) for emotional or behavioral problems among children of fathers with depressive symptoms was 1.72 (95% confidence interval [CI]: 1.33-2.23) and the aOR associated with abnormal paternal scores on the mental component scale of the Short-Form 12 was 1.33 (95% CI: 1.10 -1.62) for those within 1 SD below average and 1.48 (95% CI: 1.20 -1.84) for those Ͼ1 SD below average. CONCLUSIONS:To the best of our knowledge, this is the first study to use a representative US sample to demonstrate that living with fathers with depressive symptoms and other mental health problems is independently associated with increased rates of emotional or behavioral problems of children.

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“…13 Another issue to consider is that having older parents may have psychological consequences on children, and that increased parental age could result in earlier loss of parents, which is identifi ed as a risk factor for schizophrenia. 14 Byrne et al, however, suggest that the psychological distress caused by the death of an aging parent does not account for the relationship between risk for schizophrenia and APA. 8 Saha et al conducted a birth cohort study on children drawn from the US Collaborative Perinatal Project to examine the relationship between paternal and maternal ages and selected behavioral measures in children.…”

Section: Social Environmental Factorsmentioning

confidence: 99%

Advanced Paternal Age and the Risk of Schizophrenia: A Literature Review

Bajwa¹,

Hasija²,

Jadapalle³

et al. 2011

Psychiatric Annals

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A verage parental age is increasing in most Western countries, refl ecting the changes in professional and social life. Literature shows that in England and Wales from 1993 to 2003, the rate of older paternal age (35 to 54 years) increased from 25% to 40% and the mean paternal age increased from 29.2 years to 32.1 years. 1 Advanced paternal age is associated with accumulated environmental insults over time and is strongly associated with reductions in fertility due to impaired spermatogenesis. It is well known that in males, germ-line mutations are high due to the increased frequency of cell division over the life course. 2

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Paternal age and common mental disorders

Cited by 14 publications

References 22 publications

Paternal age and psychiatric disorders: Findings from a Dutch population registry

Paternal age and psychiatric disorders: Findings from a Dutch population registry

Paternal Depressive Symptoms and Child Behavioral or Emotional Problems in the United States

Advanced Paternal Age and the Risk of Schizophrenia: A Literature Review

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