Paternal age and spontaneous abortion after IVF with donor eggs

Medina, Rubén Danilo Méndez; Urbina, María Teresa; Benjamin, Isaac; Lerner-Biber, J.; Álvarez, María

doi:10.1016/j.fertnstert.2012.07.883

Cited by 2 publications

(3 citation statements)

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“…2008 ;Capelouto et al, 2018;Chapuis et al, 2017;Cito et al, 2019;Frattarelli et al, 2008;Gallardo et al, 1996;Garcia-Ferreyra et al, 2015;Garcia-Ferreyra et al, 2018;Ho et al, 2015;Horta et al, 2019;Kaarouch et al, 2018;Klonoff-Cohen and Natarajan, 2004;Kumtepe et al, 2003;Luna et al, 2009;Medina et al, 2012;Meyer et al, 2012;McPherson et al, 2018;Nijs et al, 2011;Park et al, 2018;Spandorfer et al, 1998;Tiegs et al, 2017;Tsai et al, 2013;Whitcomb et al, 2011;Wu et al, 2016;Yu et al, 2019). FIGURE 1 is a PRISMA flow chart that illustrates the breakdown of the selected studies according to type of study.…”

Section: Resultsmentioning

confidence: 99%

Does advanced paternal age affect outcomes following assisted reproductive technology? A systematic review and meta-analysis

Murugesu

Kasaven

Petrie

et al. 2022

Reproductive BioMedicine Online

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Section: Resultsmentioning

confidence: 99%

Does advanced paternal age affect outcomes following assisted reproductive technology? A systematic review and meta-analysis

Murugesu

Kasaven

Petrie

et al. 2022

Reproductive BioMedicine Online

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“…Where possible, to control for maternal age, we excluded the results reported for women R40 years (27). Of the donor oocyte studies, four studies reported the oocyte age as being %31 years (33)(34)(35)(36), whereas the remaining studies reported oocyte age as being <35 years. Four studies reported that donors had a normal ovarian reserve either based on antral follicle count >8 (37-39) or based on assessment of baseline gonadotropins (33,34,37,38).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…One study included semen samples surgically obtained, as a frozen specimen or by electroejaculation (36). Three studies were conference abstracts from which it was possible to extract data (35,40,41). We performed a subgroup analysis of the impact of paternal age >50 years, where maternal age was %39 years, in both autologous and donor oocyte studies where outcomes were reported.…”

Section: Study Characteristicsmentioning

confidence: 99%

Effect of paternal age on outcomes in assisted reproductive technology cycles: systematic review and meta-analysis

et al. 2020

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Objective: To investigate whether paternal age exerts an independent effect on the clinical outcomes of assisted reproductive technology (ART) cycles. Evidence Review: Observational studies were identified through a systematic search of MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and National Health Service evidence. Data for women aged %39 years were extracted and analyzed. We included all studies, both autologous and donor oocyte, into separate analyses of the effect of paternal age on ART outcome. We excluded studies in azoospermic men, women aged R40 years, ART including preimplantation genetic testing, and involving donor sperm. The included studies scored well on the Newcastle-Ottawa Quality Assessment Scale for observational studies. The primary outcome was live birth rate and secondary outcome measures were clinical pregnancy rate and miscarriage rate. When pooling data, the random-effects model was used to counter the effect of heterogeneity in the studies. Result(s): Live birth rate was reported in three autologous oocyte studies (2,926 cycles) and five donor oocyte studies (7,648 cycles). Live birth rate was found to be increased significantly when male age was <40 years in autologous oocyte studies but no difference in live birth rate was found in donor oocyte studies. Clinical pregnancy rates were found to be statistically higher when the paternal age was under 40 years in autologous oocyte studies, however, there was no difference in clinical pregnancy in the same age category when donor oocyte studies were analyzed. Miscarriage rate was reported in two autologous oocyte studies (970 cycles) and four donor oocyte studies (3,741 cycles). Miscarriage was found to be more likely with male age >40 years in autologous studies. In donor oocyte studies, the miscarriage rate was not increased when male age was >50 years. All of the autologous oocyte studies reported a statistically significant association between male age and female age. Conclusion(s): The findings of this review and meta-analysis, based on the donor oocyte model, suggest that advanced paternal age does not exert an independent effect on the outcome of ART cycles. Miscarriage rates do not appear to be increased even for men >50 years of age after treatment with donor oocytes. The meta-analysis of autologous oocyte studies suggests that increasing male age may have a deleterious effect on the outcome of ART, however, this may be confounded by the strong association with increasing maternal age. (Fertil Steril Rev Ò 2020;1:16-34. Ó2020 by American Society for Reproductive Medicine.

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Paternal age and spontaneous abortion after IVF with donor eggs

Cited by 2 publications

References 0 publications

Does advanced paternal age affect outcomes following assisted reproductive technology? A systematic review and meta-analysis

Does advanced paternal age affect outcomes following assisted reproductive technology? A systematic review and meta-analysis

Effect of paternal age on outcomes in assisted reproductive technology cycles: systematic review and meta-analysis

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