2015
DOI: 10.1530/rep-14-0676
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Paternal obesity in a rodent model affects placental gene expression in a sex-specific manner

Abstract: Fetal growth restriction (FGR) is a major obstetric complication stemming from poor placental development. We have previously demonstrated that paternal obesity in mice is associated with impaired embryo development and significantly reduced fetal and placental weights. We hypothesised that the FGR observed in our rodent model of paternal diet-induced obesity is associated with alterations in metabolic, cell signalling and stress pathways. Male C57BL/6 mice were fed either a normal or high-fat diet for 10 week… Show more

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Cited by 67 publications
(58 citation statements)
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“…Either maternal or paternal HFD in isolation has been shown to change the transcriptome of the developing placenta (5,8,46,75). Thus, we determined whether there were additive effects of combined paternal and maternal HFD on placental gene expression during gestation.…”
Section: Paternal and Maternal Hfd Alter Placental Gene Expressionmentioning
confidence: 99%
See 1 more Smart Citation
“…Either maternal or paternal HFD in isolation has been shown to change the transcriptome of the developing placenta (5,8,46,75). Thus, we determined whether there were additive effects of combined paternal and maternal HFD on placental gene expression during gestation.…”
Section: Paternal and Maternal Hfd Alter Placental Gene Expressionmentioning
confidence: 99%
“…As both in vivo-and in vitro-derived fetuses and placentas were reduced in size with combined paternal and maternal obesity, and since both pater-nal and maternity obesity alone alter placental gene expression (5,8,46,75), we established whether key imprinting, growth, nutrition, and mitochondrial specific gene regulation were further impaired when both parents were obese. We observed sex-specific effects on placental gene expression that were expected given the numerous reports of sex-specific phenotypes in offspring in models of maternal and paternal obesity (18,19,22,23,63,66,67).…”
Section: Alterations To Fetal Health From Combined Paternal and Matermentioning
confidence: 99%
“…A recent report also suggests that a paternal diet high in fat resulted in sex-dependent DNA methylation and gene expression changes in the placenta of his progeny (66). Such placental changes may detrimentally impact fetal development and contribute to offspring DOHaD effects.…”
Section: Nutritionalmentioning
confidence: 99%
“…Maternal-and paternal-induced changes in epigenetic marks of the placenta include alteration of DNA methylation patterns in nonimprinted and imprinted genes (55,66,(77)(78)(79)82), miRNA (trophomiRs) expression (61,83), and genes mediating epigenetic pathways (56). Sex differences in placental expression have also been reported in these coding and noncoding genes (55,56,61,77).…”
Section: Epimutationsmentioning
confidence: 99%
“…28,29 The ASQ encourages parents to perform activities with their children and then respond to questions capturing 5 developmental domains (ie, fine motor, gross motor, communication, personal-social functioning, and problem-solving ability). Parents completed the ASQ at 4 to 6,8,12,18,24,30, and 36 months of age, corrected for gestational age. 30,31 We implemented the ASQ second edition 31 at ages 4 to 12 months and the third edition 30 from 18 months onward.…”
Section: Developmental Assessmentmentioning
confidence: 99%