Paternal Tobacco Smoke Correlated to Offspring Asthma and Prenatal Epigenetic Programming

Wu, Ching‐Yuan; Hsu, Te‐Yao; Chang, Jen-Chieh; Ou, Chia-Yu; Kuo, Ho-Chang; Liu, Chieh-An; Wang, Chih‐Lu; Chuang, Hai‐Hua; Chen, Chie‐Pein; Yang, Kuender D.

doi:10.3389/fgene.2019.00471

Cited by 45 publications

(42 citation statements)

References 45 publications

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“…The effect sizes appeared to be moderated by family history of asthma and duration of breastfeeding based on study‐specific reporting. The lack of specificity to a defined period of wheeze onset suggests genetic and epigenetic effects probably take precedence over temporal programming instituted by postnatal tobacco exposure 50 . Additionally, similar explanations may be accorded to differences in geography defined by climate and related ventilation (ie, better ventilation in warmer than colder climate) 18 …”

Section: Discussionmentioning

confidence: 99%

Childhood wheeze trajectory‐specific risk factors: A systematic review and meta‐analysis

Owora

Zhang

2020

Pediatric Allergy Immunology

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Background: There is growing interest in the use of latent trajectory methodology to identify wheeze patterns in heterogeneous populations of children. This study systematically reviewed and meta-analyzed childhood wheeze trajectory studies to identify childhood wheeze trajectory group-specific risk factors among children from birth through to adolescence. Methods: We included studies that used latent trajectory methodology to identify wheeze trajectories and associated risk factors. We searched PubMed, EMBASE, and Google Scholar from 2000 through September 30, 2019, for relevant studies. The study was conducted according to the PRISMA recommendations. Results: Thirteen cohort studies conducted in eleven high-income countries were included in our meta-analysis with the length of follow-up ranging from 3 to 18 years. Five distinct latent wheeze trajectory groups were identified: Never/Infrequent, Early-Transient, Early-Persistent, Intermediate-Onset, and Late-Onset. We found moderate-to-strong evidence that family history of asthma predicted persistent childhood wheezing among male children but with lower risk among first-born children. There was weak-to-moderate evidence for childhood atopy, male sex, short duration of breastfeeding, tobacco exposure, daycare attendance, and having siblings as risk factors for Early-Transient wheezing; except for breastfeeding, these factors were also associated with intermediate and Late-Onset wheezing with varying effect sizes in high-risk vs general population cohorts. Conclusions: Our findings confirm the consistency of wheeze trajectory groups defined by onset, peak prevalence, and duration; we also suggest a common nomenclature for future trajectory studies. With the exception of the relationship between a family history of asthma and persistent childhood wheezing, commonly suspected wheeze risk factors (childhood atopy, male sex, short duration of breastfeeding, tobacco exposure, daycare attendance, and having siblings) are not trajectory-specific and have varying effects in high-risk vs general population cohorts. Delineation of time-varying risk factor effects may be critical to the specificity of wheeze trajectory group prediction to better inform prognosis and targeted early preventive intervention among at-risk children.

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Section: Discussionmentioning

confidence: 99%

Childhood wheeze trajectory‐specific risk factors: A systematic review and meta‐analysis

Owora

Zhang

2020

Pediatric Allergy Immunology

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“…Prenatal paternal smoking exposure was also associated with childhood asthma development at 6 years of age, presumably mediated by an IgE-independent mechanism. Prenatal paternal smoking led to epigenetic modifications in certain genes as such as LIM Domain Only 2 (LMO 2 ) and interleukin-10 (IL-10) via cytosine-phosphate-guanine (CpG) methylation, and these modifications are correlated to childhood asthma development [ 30 ].…”

Section: Air Pollution and Risk Of Asthmamentioning

confidence: 99%

Impact of Air Pollution on Asthma Outcomes

Tiotiu

Novakova

Nedeva

et al. 2020

IJERPH

313

151

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Asthma is a chronic respiratory disease characterized by variable airflow obstruction, bronchial hyperresponsiveness, and airway inflammation. Evidence suggests that air pollution has a negative impact on asthma outcomes in both adult and pediatric populations. The aim of this review is to summarize the current knowledge on the effect of various outdoor and indoor pollutants on asthma outcomes, their burden on its management, as well as to highlight the measures that could result in improved asthma outcomes. Traffic-related air pollution, nitrogen dioxide and second-hand smoking (SHS) exposures represent significant risk factors for asthma development in children. Nevertheless, a causal relation between air pollution and development of adult asthma is not clearly established. Exposure to outdoor pollutants can induce asthma symptoms, exacerbations and decreases in lung function. Active tobacco smoking is associated with poorer asthma control, while exposure to SHS increases the risk of asthma exacerbations, respiratory symptoms and healthcare utilization. Other indoor pollutants such as heating sources and molds can also negatively impact the course of asthma. Global measures, that aim to reduce exposure to air pollutants, are highly needed in order to improve the outcomes and management of adult and pediatric asthma in addition to the existing guidelines.

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“…DNA hyper-methylation is one of the most investigated epigenetic events linked to childhood asthma. Most studies reported a hyper-methylation of CG-region [149], while others showed a hypo-methylation of the same sites in children with asthma [150]. Assessing the DNA methylation of 1629 children, Wu et al reported hyper-methylation of IL-10 and LIM Domain Only-2 (LMO2) [150].…”

Section: Early In Life Epigenetic Events and The Predisposition Of Thmentioning

confidence: 99%

“…Most studies reported a hyper-methylation of CG-region [149], while others showed a hypo-methylation of the same sites in children with asthma [150]. Assessing the DNA methylation of 1629 children, Wu et al reported hyper-methylation of IL-10 and LIM Domain Only-2 (LMO2) [150]. Interestingly, there is evidence that childhood asthma, as well as COPD (later in life), is linked to a modification of the TGF-β signaling pathway by epigenetic events earlier in life [151].…”

Section: Early In Life Epigenetic Events and The Predisposition Of Thmentioning

confidence: 99%

Immunologic and Non-Immunologic Mechanisms Leading to Airway Remodeling in Asthma

Fang

Sun

Roth

2020

IJMS

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Asthma increases worldwide without any definite reason and patient numbers double every 10 years. Drugs used for asthma therapy relax the muscles and reduce inflammation, but none of them inhibited airway wall remodeling in clinical studies. Airway wall remodeling can either be induced through pro-inflammatory cytokines released by immune cells, or direct binding of IgE to smooth muscle cells, or non-immunological stimuli. Increasing evidence suggests that airway wall remodeling is initiated early in life by epigenetic events that lead to cell type specific pathologies, and modulate the interaction between epithelial and sub-epithelial cells. Animal models are only available for remodeling in allergic asthma, but none for non-allergic asthma. In human asthma, the mechanisms leading to airway wall remodeling are not well understood. In order to improve the understanding of this asthma pathology, the definition of “remodeling” needs to be better specified as it summarizes a wide range of tissue structural changes. Second, it needs to be assessed if specific remodeling patterns occur in specific asthma pheno- or endo-types. Third, the interaction of the immune cells with tissue forming cells needs to be assessed in both directions; e.g., do immune cells always stimulate tissue cells or are inflamed tissue cells calling immune cells to the rescue? This review aims to provide an overview on immunologic and non-immunologic mechanisms controlling airway wall remodeling in asthma.

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Paternal Tobacco Smoke Correlated to Offspring Asthma and Prenatal Epigenetic Programming

Cited by 45 publications

References 45 publications

Childhood wheeze trajectory‐specific risk factors: A systematic review and meta‐analysis

Childhood wheeze trajectory‐specific risk factors: A systematic review and meta‐analysis

Impact of Air Pollution on Asthma Outcomes

Immunologic and Non-Immunologic Mechanisms Leading to Airway Remodeling in Asthma

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