A fan is part of the core equipment of a super-pressure balloon altitude control system, and high-performance fans have a significant impact on the altitude control capability and flight safety of super-pressure balloons. This paper proposes a mixed-flow MIX-140 fan for use with super-pressure balloons. Changes in the fanβs operating characteristics at various flight altitudes of a super-pressure balloon were investigated. First, the performance of the fan at ground level was obtained through numerical simulation and compared with measured data of the prototype to verify the accuracy of the simulation analysis. On this basis, the influences of changes in the atmospheric pressure, temperature, and fan speed on fan performance were investigated through numerical simulation. Furthermore, the MIX-140 fan was compared with an existing fan, and the variation of two parameters, namely, the ratio of inflation volume per unit time and the ratio of inflation volume per unit power, were investigated at different altitudes. Finally, the changes in the operating characteristics of the fan under different high-altitude environments were investigated through actual testing. The results reveal that changes in altitude can lead to significant changes in fan performance, and changes in the atmospheric pressure, temperature, and fan speed affect the fanβs working characteristics. Compared with the existing fan, the MIX-140 fan achieves an average increase of 295.8% in the inflation volume per unit of time, and 14.6% in the inflation volume per unit of power at altitudes of 16β20 km. The performance variation characteristics and testing methods of this proposed super-pressure balloon fan can provide a foundation and reference for the design of a super-pressure balloon control system.