Path loss is an attenuation of Global System for Mobile Communication (GSM) signal between Base Transceiver Station (BTS) and Mobile Station (MS). Path loss helps network engineers in planning, designing and implementing telecommunication networks. This work examines the applicability of Hata, COST 231, ECC – 33, Ericsson and SUI models in a medium city (Mubi) in Adamawa State, Nigeria. Root mean square error (RMSE) between the measured and the predicted losses (output of the models) is obtained as 7.632dB, 14.736dB, 10.593dB, 0.639dB and 23.491dB respectively. Ericsson model is found to have the least RMSE. Therefore, it is selected as the best fit model and modified. Furthermore, the modified model is optimized to recover missing or to eliminate unwanted information in the radio path using spline interpolation. The optimized model can be employed for the deployment of network resources in suburban areas of Nigeria, especially in Mubi town in Adamawa State, in order to significantly enhance GSM signal QoS. It is recommended that fuzzy logic and spline interpolation techniques may be integrated and employed to further minimize the error obtained in this work.