Pathogenesis of an experimental meningeal leukemia model

Varakis, John; Kase, Carlos S.; Wilborn, Walter H.; Cheshire, L.Bryan; Peterson, Reece L.

doi:10.1016/0090-1229(82)90124-6

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Cited by 4 publications

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“…There are mainly two different hypotheses regarding the origin of leukemic cells in CNS. Sullivan thought leukemic cells were derived from residual haematopoietic stem cells in the brain (5), while other researchers deem that leukemic cells come from the circulation, via circulation to arachnoid, extended through the pia‐glial membrane to brain parenchyma (6); alternatively leukemic cells in the skull bone marrow may directly infiltrate to dura matter and pia matter, followed by arachnoid and brain (7–10).…”

mentioning

confidence: 99%

Establishment of a nude mice model of human monocytic leukemia with CNS and multiorgan extramedullary infiltration

Li¹,

Chen²,

et al. 2006

European J of Haematology

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mentioning

confidence: 99%

Establishment of a nude mice model of human monocytic leukemia with CNS and multiorgan extramedullary infiltration

Li¹,

Chen²,

et al. 2006

European J of Haematology

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Animal Models of Leptomeningeal Cancer

Raja

Engelhard

2005

Cancer Treatment and Research

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Schabet¹,

Herrlinger²

1998

Journal of Neuro-Oncology

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Animal models of leptomeningeal metastasis (LM) should give insight into pathophysiological mechanisms and allow to evaluate new treatments including their neurotoxicity. Syngeneic models use tumor cells of mouse, rat, rabbit or guinea pig origin. Allogeneic models usually rely on human tumor cells injected into nude mice or rats. A review of the literature revealed 2 (4) different glioma, 3 medulloblastoma, 3 (3) carcinoma, 3 (1) melanoma, 1 rhabdomyosarcoma, 2 (8) leukemia and 2 (2) non-Hodgkin's lymphoma allogeneic (syngeneic) models of LM. These models have been used to study the evolution of LM and to evaluate systemic or intrathecal chemotherapy, intrathecal immunotherapy (interleukin-2, interferon-beta, uncoupled, toxin- or radionuclide-conjugated antibodies), and recently gene therapeutic approaches. On the whole, pathophysiological, therapeutic and neurotoxic findings have been well transferable to the clinical situation. Therefore, it seems rational to preclinically test new treatments in an appropriate animal model of LM before using them in patients.

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Pathogenesis of an experimental meningeal leukemia model

Cited by 4 publications

References 11 publications

Establishment of a nude mice model of human monocytic leukemia with CNS and multiorgan extramedullary infiltration

Establishment of a nude mice model of human monocytic leukemia with CNS and multiorgan extramedullary infiltration

Animal Models of Leptomeningeal Cancer

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