Pathogenesis of Bronchopulmonary Dysplasia

Chess, Patricia R.; D’Angio, Carl T.; Pryhuber, Gloria S.; Maniscalco, William M.

doi:10.1053/j.semperi.2006.05.003

Cited by 150 publications

(103 citation statements)

References 104 publications

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“…1 Infants born prematurely also have reduced antioxidant defenses and are sensitive to oxidant injury that can be exacerbated by therapeutic oxygen. [2][3][4][5] Although improved clinical treatments have reduced the incidence of airway injury, inflammation, and fibrosis typically seen in the pre-surfactant era, infants dying from BPD today have simplified alveoli that are less vascularized. 6 Analogous to the pathology seen in these infants, exposure of newborn rodents to Ն85% oxygen for 10 to 14 days causes alveolar simplification and abnormal vascular development.…”

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confidence: 99%

Neonatal Hyperoxia Causes Pulmonary Vascular Disease and Shortens Life Span in Aging Mice

Yee

White

Awad

et al. 2011

The American Journal of Pathology

113

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Bronchopulmonary dysplasia is a chronic lung disease observed in premature infants requiring oxygen supplementation and ventilation. Although the use of exogenous surfactant and protective ventilation strategies has improved survival, the long-term pulmonary consequences of neonatal hyperoxia are unknown. Here, we investigate whether neonatal hyperoxia alters pulmonary function in aging mice. By 67 weeks of age, mice exposed to 100% oxygen between postnatal days 1 to 4 showed significantly a shortened life span (56.6% survival, n ‫؍‬ 53) compared to siblings exposed to room air as neonates (100% survival, n ‫؍‬ 47). Survivors had increased lung compliance and decreased elastance. There was also right ventricular hypertrophy and pathological evidence for pulmonary hypertension, defined by reduction of the distal microvasculature and the presence of numerous dilated arterioles expressing von Willebrand factor and ␣-smooth muscle actin. Consistent with recent literature implicating bone morphogenetic protein (BMP) signaling in pulmonary vascular disease, BMP receptors and downstream phospho-Smad1/ 5/8 were reduced in lungs of aging mice exposed to neonatal oxygen. BMP signaling alterations were not observed in 8-week-old mice. These data suggest that loss of BMP signaling in aged mice exposed to neonatal oxygen is associated with a shortened life span, pulmonary vascular disease, and associated cardiac failure. People exposed to hyperoxia as neonates may be at increased risk for pulmonary hypertension.

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confidence: 99%

Neonatal Hyperoxia Causes Pulmonary Vascular Disease and Shortens Life Span in Aging Mice

Yee

White

Awad

et al. 2011

The American Journal of Pathology

113

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“…Se han jerarquizado otros factores involucrados en su patogenia, como inflamación o infección, administración excesiva de líquidos, edema pulmonar, persistencia o reapertura del conducto arterioso, aumento de la resistencia de las vías aéreas, inmadurez de los sistemas antioxidantes, deficiencias nutricionales, insuficiencia suprarrenal temprana y predisposición genética. [11][12][13][14] La etiopatogenia de la DBP es multifactorial. Muchos factores contribuyen a su aparición y es probable que actúen de forma aditiva o sinérgica para promover la lesión.…”

Section: Fisiopatologíaunclassified

“…Distintos mecanismos de lesión interrumpen el desarrollo normal del pulmón y detienen la alveolización y la vascularización. 9,13 Las alteraciones son parcelares y se encuentra tejido normal adyacente.…”

Section: Fisiopatologíaunclassified

“…Uno de los agentes infecciosos que produce una respuesta inflamatoria es Ureaplasma urealyticum. 4,11,13 Conducto arterioso permeable o persistente. Manejo de los líquidos: el conducto arterioso permeable es una complicación frecuente en las primeras semanas de vida en los prematuros extremos con insuficiencia respiratoria.…”

Section: / Arch Argent Pediatr 2013;111(2):165-172 / Subcomisiones Cunclassified

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Seguimiento neumológico de los niños con displasia broncopulmonar al alta de la Unidad de Cuidados Intensivos Neonatal. Parte 1: Epidemiología, fisiopatología y clínica

Giubergia¹,

Rentería²,

Bauer³

et al. 2013

Arch Argent Pediat

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INTRODUCCIÓNLa displasia broncopulmonar (DBP) es la enfermedad pulmonar crónica más frecuente del lactante; se expresa con una importante morbilidad en los primeros años de vida, e implica un riesgo de secuela pulmonar a largo plazo o de resultados adversos en el neurodesarrollo.Se presenta durante el período neonatal en recién nacidos de parto prematuro que necesitaron tratamiento por insuficiencia respiratoria en las primeras semanas de vida. Después del egreso neonatal, los prematuros con DBP requieren una atención pediátrica programada e interdisciplinaria.Esta guía está dirigido a pediatras neumólogos, pediatras en general y otros profesionales de la salud y afines vinculados al seguimiento y la atención de los niños nacidos de parto prematuro. BREVE RESEÑA HISTÓRICALa DBP fue descrita en 1967 por William Northway en recién nacidos prematuros con síndrome de dificultad respiratoria (SDR) o enfermedad de la membrana hialina (EMH), que recibieron tratamiento con ventilación mecánica y altas concentraciones de Conflicto de intereses:Ninguno que declarar.

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“…Infants born prematurely frequently go on to develop BPD. Prematurity is the primary risk factor for BPD, followed by oxygen toxicity and ventilation induced lung damage (reviewed in Jobe and Ikegami 29 and Chess et al 30 ). The 'new' BPD pathology consists of arrested alveolar development, resulting in decreased total alveoli, and abnormal vasculature localization observed in the lung periphery.…”

Section: -22mentioning

confidence: 99%

Intracellular and extracellular serpins modulate lung disease

Askew

Silverman

2008

J Perinatol

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An imbalance between peptidases and their inhibitors leads to pulmonary disease. Imbalances occur in the adult and the neonate at risk for a specific set of lung pathologies. Serpins (serine peptidase inhibitors) make up the major source of antipeptidase activity in the lung. The purpose of this review is to describe the serpin mechanism of inhibition, their roles in the normal and pathological lung and their potential as therapeutic agents.

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Pathogenesis of Bronchopulmonary Dysplasia

Cited by 150 publications

References 104 publications

Neonatal Hyperoxia Causes Pulmonary Vascular Disease and Shortens Life Span in Aging Mice

Neonatal Hyperoxia Causes Pulmonary Vascular Disease and Shortens Life Span in Aging Mice

Seguimiento neumológico de los niños con displasia broncopulmonar al alta de la Unidad de Cuidados Intensivos Neonatal. Parte 1: Epidemiología, fisiopatología y clínica

Intracellular and extracellular serpins modulate lung disease

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