Pathogenesis of Chronic Plaque Psoriasis and Its Intersection With Cardio-Metabolic Comorbidities

Gisondi, Paolo; Bellinato, Francesco; Girolomoni, Giampiero; Albanesi, Cristina

doi:10.3389/fphar.2020.00117

Cited by 95 publications

(101 citation statements)

References 100 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the course of Ps, increased triglycerides, LDL cholesterol and decreased HDL cholesterol values are the most frequently observed lipid disturbances [1,2]. In our study, the levels of total CHOL and TG as well as CHOL/HDL and TG/HDL ratios were significantly higher in Ps patients than in HVs, while LDL-CHOL did not differ between both groups.…”

Section: Discussionsupporting

confidence: 46%

Osteopontin Serum Concentration and Metabolic Syndrome in Male Psoriatic Patients

Bartosińska

Przepiórka-Kosińska

Sarecka-Hujar

et al. 2021

JCM

View full text Add to dashboard Cite

Psoriasis (Ps) is an immune-mediated inflammatory skin disease that is widely associated with the clinical features of metabolic syndrome (MetS), including hypertension, abdominal obesity, insulin resistance, type 2 diabetes and dyslipidemia. Osteopontin (OPN), a multifunctional protein involved in the modulation of inflammatory processes, may contribute to the development of atherosclerosis and MetS. Therefore, the aim of the study was the assessment of the correlation between OPN concentration in the peripheral blood and the presence of MetS as well as its particular components in the Ps patients. The study comprised 107 male Ps patients (50 patients with MetS and 57 without MetS) and 38 healthy volunteers (HVs). The concentration of OPN in serum was determined using enzyme-linked immunosorbent assay (ELISA) method. Fasting blood glucose and lipid profile components: total cholesterol (total CHOL), high-density lipoprotein cholesterol (HDL-CHOL), low-density lipoprotein cholesterol (LDL-CHOL), triglycerides (TG) were examined. Ps patients with MetS had significantly higher obesity, systolic blood pressure, TG, CHOL/HDL, LDL/HDL and TG/HDL ratios than Ps patients without MetS. OPN serum concentration was significantly higher in the Ps patients than in the HVs (p = 0.022) but not significantly different between the Ps patients with and without MetS (p = 0.275). OPN serum concentration in Ps patients correlated negatively with total CHOL (p = 0.004) and TG (p = 0.009). OPN is increased in Ps patients and may serve as a biomarker of some lipid abnormalities in them.

show abstract

Section: Discussionsupporting

confidence: 46%

Osteopontin Serum Concentration and Metabolic Syndrome in Male Psoriatic Patients

Bartosińska

Przepiórka-Kosińska

Sarecka-Hujar

et al. 2021

JCM

View full text Add to dashboard Cite

show abstract

“…This association could be due to shared genetic factors and chronic inflammatory pathways between psoriasis and MetS. 17 Autophagy study has been growing in skin diseases including psoriasis. 18 In the same context, autophagy has a growing contribution to MetS pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Effect of Metabolic Syndrome on the Autophagy Marker LC3 in Psoriasis Vulgaris Patients: A Cross-Sectional Study

Nada

Muhammad

Ahmed

et al. 2020

CCID

View full text Add to dashboard Cite

Purpose Psoriasis vulgaris, one of the most prevalent chronic inflammatory skin diseases, is associated with metabolic syndrome (MetS). Autophagy, an intracellular degradation system is essential for cell survival and differentiation, and its dysfunction may contribute to metabolic diseases. A cross-sectional study was conducted on 38 psoriasis vulgaris patients and 16 healthy control subjects to 1) Assess immunohistochemical (IHC) expression of microtubule-associated protein light chain 3 (LC3); 2) Evaluate the relationship between Psoriasis Area Severity Index (PASI) score, and LC3 expression. Patients and Methods PASI score was evaluated for all psoriasis patients. Lipid profile, blood sugar, and CRP were done for all patients and controls. A punch biopsy was taken from lesional and perilesional skin of psoriasis patients and normal skin of the controls. Tissue sections were prepared. IHC LC3 staining was done and evaluated. Results LC3 was nearly absent, in the epidermis of the lesional skin of psoriasis while it was strong among control (p=0.001). LC3 expression in the lesional skin of psoriasis vulgaris was lower than its expression in perilesional (p=0.001). However, LC3 expression was not significantly changed with PASI or the presence/absence of MetS. Conclusion A potential link between psoriasis vulgaris and autophagy as assessed by LC3 could be present. LC3 was down-regulated in psoriasis lesions than in normal skin. However, its expression did not change with PASI or MetS. An autophagy enhancer might be used as a possible therapeutic target in psoriasis vulgaris patients.

show abstract

“…Psoriasis is a chronic inflammatory skin disorder resulting from genetic and environmental factors, in which disturbances of innate and adaptive cutaneous immune responses lead to uncontrolled keratinocyte proliferation and dysfunctional differentiation [ 29 ]. In psoriasis, IL-17A-producing CD4 + and CD8 + T cells play a key pathogenic role.…”

Section: Ll-37 In Autoimmune Diseasesmentioning

confidence: 99%

“…In the early events of psoriasis development, keratinocytes overproduce several innate immunity mediators, including IL-1 cytokines, chemokines, and AMPs—in particular LL-37, HBD-2, and psoriasin. These are involved in the activation and skin recruitment of innate immunity cells, such as plasmacytoid dendritic cells (pDC), neutrophils, and macrophages and mast cells ( Figure 1 ) [ 27 , 29 ]. In 2007, Lande et al demonstrated that LL-37 is the principal trigger of the pathogenic innate immune responses in psoriatic skin, providing the first link between an antimicrobial defense system and the pathogenesis of psoriasis [ 19 ].…”

Section: Ll-37 In Autoimmune Diseasesmentioning

confidence: 99%

“…Epidermal keratinocytes are the “first-line” skin cells responding to injury, and they may act as the earlier source of LL-37, HBD-2, and HBD-3. They can release LL-37 upon UV irradiation or physical trauma, as well as stimulation with bacterial or viral products (i.e., flagellin, LPSs, or viral RNA/DNA) or innate primary cytokines, such as IL-36γ, thus triggering paracrine and autocrine inflammatory loops [ 27 , 29 , 37 , 38 ]. Keratinocyte-derived LL-37 induces the release of IL-1 cytokines, including IL-36γ, by psoriatic keratinocytes themselves ( Figure 1 ) [ 39 ].…”

Section: Ll-37 In Autoimmune Diseasesmentioning

confidence: 99%

See 1 more Smart Citation

Immunomodulatory Role of the Antimicrobial LL-37 Peptide in Autoimmune Diseases and Viral Infections

et al. 2020

Self Cite

View full text Add to dashboard Cite

Antimicrobial peptides (AMPs) are produced by neutrophils, monocytes, and macrophages, as well as epithelial cells, and are an essential component of innate immunity system against infection, including several viral infections. AMPs, in particular the cathelicidin LL-37, also exert numerous immunomodulatory activities by inducing cytokine production and attracting and regulating the activity of immune cells. AMPs are scarcely expressed in normal skin, but their expression increases when skin is injured by external factors, such as trauma, inflammation, or infection. LL-37 complexed to self-DNA acts as autoantigen in psoriasis and lupus erythematosus (LE), where it also induces production of interferon by plasmocytoid dendritic cells and thus initiates a cascade of autocrine and paracrine processes, leading to a disease state. In these disorders, epidermal keratinocytes express high amounts of AMPs, which can lead to uncontrolled inflammation. Similarly, LL-37 had several favorable and unfavorable roles in virus replication and disease pathogenesis. Targeting the antiviral and immunomodulatory functions of LL-37 opens a new approach to limit virus dissemination and the progression of disease.

show abstract

Pathogenesis of Chronic Plaque Psoriasis and Its Intersection With Cardio-Metabolic Comorbidities

Cited by 95 publications

References 100 publications

Osteopontin Serum Concentration and Metabolic Syndrome in Male Psoriatic Patients

Osteopontin Serum Concentration and Metabolic Syndrome in Male Psoriatic Patients

Assessment of the Effect of Metabolic Syndrome on the Autophagy Marker LC3 in Psoriasis Vulgaris Patients: A Cross-Sectional Study

Immunomodulatory Role of the Antimicrobial LL-37 Peptide in Autoimmune Diseases and Viral Infections

Contact Info

Product

Resources

About