2011
DOI: 10.21836/pem20110101
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Pathogenesis of equine endometrosis: Relevance of the growth factors transforming growth factor- a, -b1, -b2 and -b3 and matrixmetalloproteinase-2

Abstract: ZusammenfassungDie Endometrose ist eine irreversible degenerative Erkrankung der Stute und stellt einen Hauptgrund für equine Infertilität dar. Die Ätio-pathogenese der Endometrose ist bisher nicht eindeutig geklärt. Daher war das Ziel der Untersuchungen die immunhistologische Charakterisierung der glandulären und stromalen Expression der Wachstumsfaktoren Transforming growth factor-a, -b1, -b2, -b3 (TGF-a, TGFb1, -b2, -b3) und des Enzyms Matrixmetalloproteinase-2 (MMP-2) innerhalb verschieden differenzierter … Show more

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(1 citation statement)
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“…Alterations of the basal lamina are known as the initial trigger within the pathogenesis of endometrosis (Raila 2000, Kiesow et al 2011). An intact basal lamina is able to suppress the synthesis of profibrotic cytokines (Streuli et al 1993), such as TGFb, whereas damage to the basal lamina causes activation of the reparative processes (Penney and Rosenkrans 1984) that, in the endometrium, takes the form of periglandular fibrosis i.e.…”
Section: Figmentioning
confidence: 99%
“…Alterations of the basal lamina are known as the initial trigger within the pathogenesis of endometrosis (Raila 2000, Kiesow et al 2011). An intact basal lamina is able to suppress the synthesis of profibrotic cytokines (Streuli et al 1993), such as TGFb, whereas damage to the basal lamina causes activation of the reparative processes (Penney and Rosenkrans 1984) that, in the endometrium, takes the form of periglandular fibrosis i.e.…”
Section: Figmentioning
confidence: 99%