Pathogenesis of Hyperthyroidism

Singh, Ishita; Hershman, Jerome M.

doi:10.1002/cphy.c160001

Cited by 14 publications

(16 citation statements)

References 88 publications

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“…Thyroid hormones, triiodothyronine (T 3 ) and thyroxin (T 4 ) are known to regulate all most all body functions including development, differentiation and metabolism 1,2 . Compared to T 4 , T 3 is considered to be more biologically active.…”

Section: Introductionmentioning

confidence: 99%

Allylpyrocatechol, isolated from betel leaf ameliorates thyrotoxicosis in rats by altering thyroid peroxidase and thyrotropin receptors

Panda

Sikdar

Biswas

et al. 2019

Sci Rep

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Allylpyrocatechol (APC) was isolated from betel leaf and its possible role in L-thyroxin (L-T 4 )-induced thyrotoxic rats was evaluated. The disease condition, thyrotoxicosis was confirmed by higher levels of thyroid hormones and low thyrotropin (TSH) in serum. Increased hepatic activities of 5′-mono-deiodinase(5′D1), glucose-6-phospatase (G-6-Pase); serum concentrations of alanine transaminase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase(LDH) and tumour necrosis factor-alpha(TNF-α) were observed in thyrotoxic rats. Hepatic lipid peroxidation(LPO) was also increased and the endogenous antioxidants were depleted in these rats. In western blot analysis thyroid peroxidase expression was found to be reduced, whereas thyrotropin receptor(TSHR) expression was enhanced in thyroid gland of these animals. On the other hand, APC treatment in thyrotoxic rats decreased the levels of serum thyroid hormones, ALT, AST, TNF-α and LDH, as well as hepatic 5′ D1 and G-6-Pase activities. However, it increased the serum TSH levels. APC also reduced the hepatic LPO and increased the cellular antioxidants in thyrotoxic rats. However, expression of TSHR was inhibited and TPO was increased by APC. The test compound also improved histological features in both liver and thyroid. Present report appears to be the first one that indicates the positive role of APC in ameliorating T 4 -induced thyrotoxicosis.

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Section: Introductionmentioning

confidence: 99%

Allylpyrocatechol, isolated from betel leaf ameliorates thyrotoxicosis in rats by altering thyroid peroxidase and thyrotropin receptors

Panda

Sikdar

Biswas

et al. 2019

Sci Rep

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“…ACS was not diagnosed until the electrocardiogram and TNT-Hs test were completed. Patients with hyperthyroidism often exhibit a high metabolic state[ 14 ], and the incidence of diabetes and dyslipidemia in such patients is lower than that in ordinary patients, indicating that the conditions for atherosclerosis are lacking and patients are less likely to have CHD. It is important to understand the factors that caused atherosclerotic plaque in this young male patient with hyperthyroidism.…”

Section: Discussionmentioning

confidence: 99%

Acute coronary syndrome with severe atherosclerotic and hyperthyroidism: A case report

Zhu¹,

Zhang²,

Yun³

et al. 2021

WJCC

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BACKGROUND Acute coronary syndrome (ACS) encompasses a spectrum of cardiovascular emergencies arising from the obstruction of coronary artery blood flow and acute myocardial ischemia. Recent studies have revealed that thyroid function is closely related to ACS. However, only a few reports of thyrotoxicosis-induced ACS with severe atherosclerosis have been reported. CASE SUMMARY A 33-year-old man, who had a history of hyperthyroidism without taking any antithyroid drugs and no history of coronary heart disease, experienced neck pain with occasional heart palpitations starting 3 mo prior that were aggravated after an activity. As the symptoms worsened at 21 d prior, he went to a hospital for treatment. The electrocardiogram examination showed a multilead ST segment elevation and pathological Q waves. Based on these findings and his symptoms, the patient was diagnosed with a suspected myocardial infarction and transferred to our hospital on July 2, 2020. He was diagnosed with a rare case of ACS due to coronary artery atherosclerosis in the anterior descending artery complicated by hyperthyroidism. A paclitaxel-coated drug balloon was used for treatment to avoid the use of metal stents, thus reducing the time of antiplatelet therapy and facilitating the continued treatment of hyperthyroidism. The 9-mo follow-up showed favorable results. CONCLUSION This case highlights that atherosclerosis is a cause of ACS that cannot be ignored even in a patient with hyperthyroidism.

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“…The association of pheocromocytoma with multinodular goitre is most probably incidental. If a young adult presents high blood pressure and transpirations a hyperthyroidism should be suspected (6,7).…”

Section: Thyroid Check-upmentioning

confidence: 99%

From transitory erythema to pheocromocytoma

Valea¹,

Cârșote²,

Albu³

et al. 2019

Ro Med J.

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This is a case report of a female with transitory erythema who was found with thrombocytosis caused by a pheocromocytoma. The skin changes were not accompanied by typical manifestations of an adrenergic crisis although she had high blood pressure episodes without skin colour changes. Both the erythema and the arterial hypertension controlled after the adrenal tumour was removed. Pheocromocytoma associates not only the excessive production of metanephrines and normetanephrines but also other factors like interleukins (for instance, IL-6, causing a general inflammatory syndrome including reactive thrombocytosis) eritropoietin or parathormone related peptide. Thrombocytosis is extremely rare associated with cathecolamines producing tumour and it may become a supplementary contributor to cardiovascular risk.

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Pathogenesis of Hyperthyroidism

Cited by 14 publications

References 88 publications

Allylpyrocatechol, isolated from betel leaf ameliorates thyrotoxicosis in rats by altering thyroid peroxidase and thyrotropin receptors

Allylpyrocatechol, isolated from betel leaf ameliorates thyrotoxicosis in rats by altering thyroid peroxidase and thyrotropin receptors

Acute coronary syndrome with severe atherosclerotic and hyperthyroidism: A case report

From transitory erythema to pheocromocytoma

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