Pathogenesis of Inflammatory Bowel Diseases

Yan, Yutao

doi:10.5772/28298

Cited by 4 publications

(2 citation statements)

References 148 publications

(141 reference statements)

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“…th17 and Treg cells belong to the same class of CD4+ T cell subpopulation cells, and Th17 cells play a bidirectional regulatory role in their pathogenesis, mainly pro-inflammatory, and their protection of the intestinal mucosa is achieved by maintaining the balance of the immune microenvironment, and can exacerbate intestinal mucosa through the action of TGF-β is a pleiotropic factor that both regulates B-cell function and inhibits Th1 cell function; its reduced activity can lead to autoimmune dysregulation, which can lead to the development of IBD and other diseases. The incidence of IBD is higher in young people than in others, where cytokine IL-10 or IL-10 receptor deficiency is the basis for the development of IBD, which is more difficult to treat and diagnose clinically, with rapid weight loss, more retarded growth and the development of perianal abscesses, fistulas and anal ruptures [13]. Shi Yingqi et al conducted a correlation analysis of serum TNF-α and IL-6 levels in 65 patients with IBD, and the results showed that the expression levels of TNF-α and IL-6 factors were reduced and their relevance to the inflammatory response of the intestine [14].…”

Section: Cytokines and Ibdmentioning

confidence: 99%

Advances in the study of the pathogenesis of cytokines in inflammatory bowel disease

2023

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In recent years, with the continuous development of medical technology, people pay more and more attention to health. From a global perspective, the prevalence of inflammatory bowel disease (IBD) is increasing, and this disease is recurrent and persistent, and may bring physical and psychological harm to patients in the later stage, so the diagnosis and treatment of IBD and its prognostic effect become a clinical. This makes the management and prognosis of IBD a clinical challenge. The cause of IBD is still unclear, but as research continues, it is thought that the pathogenesis of IBD may be related to abnormal immune imbalances in the gut caused by environmental, genetic, immune and intestinal micro-ecological factors. Nowadays, research on the pathogenesis of IBD has been deepened and refined, and it has been found that there are more studies on immune factors and their conclusions are widely accepted, but the mechanisms of interleukin (IL) and tumour necrosis factor (TNF) are more widely studied. This article will mainly review the pathogenesis of IBD from the perspective of cytokines and provide reference for future clinical studies.

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Section: Cytokines and Ibdmentioning

confidence: 99%

Advances in the study of the pathogenesis of cytokines in inflammatory bowel disease

2023

medsc

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“…Both of these diseases tend to appear in young adults, but can actually appear at any age (Wehkamp et al, 2016). It is an idiopathic and chronic disease and can result in significant morbidity and mortality, as shown in data from Denmark (Yan, 2012;Jess et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Effect of Calorie Restriction on Intestinal Inflammation in Mice Treated with a High-Calorie Diet

Harlinda¹,

Wiyasihati²,

Kurniasari³

et al. 2022

CMUJNS

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Inflammatory bowel disease (IBD) is classified into ulcerative colitis and Crohn's disease. It is chronic inflammation of gastrointestinal tract and idiopathic disease. Sugar is proved to be risk factor for IBD. Calorie restriction is a nutrition intervention to reduce energy intake and can reduce chronic desease. This study aims to determine the difference in the effect of a high-calorie diet and calorie restriction on intestinal inflammation. Eight-week-old healthy female Balb/c mice were divided into two groups. The high calorie (HC) group was fed standard diet plus oral gavage of glucose solution every day for 4 weeks. The dose of glucose solution was 0.0325 ml/gBW or 3-5% additional calories each day. The calorie restriction (CR) group had their calorie intake restricted to 50% of standard diet 3 times a week. After 4 weeks of treatment, the mice had their colon removed. The assessment of the intestinal inflammation was carried out using a light microscope, with a scoring system by Erben et al (2014) in HE staining. The mean score of the HC group was 1.22, this was higher than the CR group with a mean score of 1.18 even tough the result revealed that the scores of intestinal inflammation were not significantly different in the two groups (P = 0.827). However, there is no evidence for the underlying mechanism of intestinal inflammation by high-calorie diet and improvement of intestinal inflammation in high-calorie diet via calorie restriction. Thus, further research is needed on other calorie restriction methods in high-calorie diet study. Keywords: High calorie diet, Calorie restriction, Intestinal inflammation

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Animal models of inflammatory bowel disease: a review

et al. 2014

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Inflammatory bowel disease (IBD) represents a group of idiopathic chronic inflammatory intestinal conditions associated with various areas of the GI tract, including two types of inflammatory conditions, i.e., ulcerative colitis (UC) and Crohn's disease (CD). Both UC and CD are chronic inflammatory disorders of the intestine; in UC, inflammation starts in the rectum and generally extends proximally in a continuous manner through the entire colon. Bloody diarrhea, presence of blood and mucus mixed with stool, accompanied by lower abdominal cramping, are the characteristic symptoms of the disease. While in CD, inflammatory condition may affect any part of the GI tract from mouth to anus. It mainly causes abdominal pain, diarrhea, vomiting and weight loss. Although the basic etiology of IBD is unknown, there are several factors that may contribute to the pathogenesis of this disease, such as dysregulation of immune system or commensal bacteria, oxidative stress and inflammatory mediators. In order to understand these different etiological factors, a number of experimental models are available in the scientific research, including chemical-induced, spontaneous, genetically engineered and transgenic models. These models represent a major source of information about biological systems and are clinically relevant to the human IBD. Since there is less collective data available in one single article discussing about all these models, in this review an effort is made to study the outline of pathophysiology and various types of animal models used in the research study of IBD and other disease-related complications.

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Pathogenesis of Inflammatory Bowel Diseases

Cited by 4 publications

References 148 publications

Advances in the study of the pathogenesis of cytokines in inflammatory bowel disease

Advances in the study of the pathogenesis of cytokines in inflammatory bowel disease

Effect of Calorie Restriction on Intestinal Inflammation in Mice Treated with a High-Calorie Diet

Animal models of inflammatory bowel disease: a review

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