Pathogenesis of Pandemic Influenza A (H1N1) and Triple-Reassortant Swine Influenza A (H1) Viruses in Mice

Belser, Jessica A.; Wadford, Debra A.; Pappas, Claudia; Gustin, Kortney M.; Maines, Taronna R.; Pearce, Melissa B.; Zeng, Hui; Swayne, David E.; Pantin‐Jackwood, Mary J.; Katz, Jacqueline M.; Tumpey, Terrence M.

doi:10.1128/jvi.02742-09

Cited by 115 publications

(130 citation statements)

References 44 publications

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“…However, most of these studies 14,15,25 were performed in BALB/c mice; in these mice, the viruses replicated more efficiently compared with seasonal H1N1 influenza, but were generally not lethal. These data are consistent with our observations in BALB/c mice.…”

Section: Discussionmentioning

confidence: 99%

Differential Host Determinants Contribute to the Pathogenesis of 2009 Pandemic H1N1 and Human H5N1 Influenza A Viruses in Experimental Mouse Models

Otte

Sauter

Alleva

et al. 2011

The American Journal of Pathology

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Section: Discussionmentioning

confidence: 99%

Differential Host Determinants Contribute to the Pathogenesis of 2009 Pandemic H1N1 and Human H5N1 Influenza A Viruses in Experimental Mouse Models

Otte

Sauter

Alleva

et al. 2011

The American Journal of Pathology

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“…Viral replication in mice, for example, is mainly confined to the lower respiratory tract (23,24). Human influenza infection is mainly limited to the upper respiratory tract.…”

Section: Alexa488mentioning

confidence: 99%

Immunization with Biodegradable Nanoparticles Efficiently Induces Cellular Immunity and Protects against Influenza Virus Infection

Knuschke

Sokolova

Rotan

et al. 2013

The Journal of Immunology

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The ability of vaccines to induce T cell responses is crucial for preventing diseases caused by viruses or bacteria. Nanoparticles (NPs) are considered an efficient tool for inducing potent immune responses. In this study, we describe a novel vaccination approach with biodegradable calcium phosphate (CaP) NPs that serve as carrier of immunoactive TLR9 ligand (CpG) combined with a viral Ag from the influenza A virus hemagglutinin. Functionalized CaP NPs were efficiently taken up by dendritic cells in vivo and elicited a potent T cell–mediated immune response in immunized mice with high numbers of IFN-γ–producing CD4+ and CD8+ effector T cells. Most importantly, both i.p. and intranasal immunization with these NPs offered protection in a mouse model of influenza virus infection. This study demonstrates the great potential of CaP NPs as a novel vaccination tool that offers substantial flexibility for several infection models.

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“…Mice are commonly used as animal models for influenza research because of the convenience of genetic modulation, though they are not ideal for transmission studies [9]. However, currently available mouse models are incapable of emulating human influenza-based disease and the immune responses to the 2009 pandemic influenza [9,13,14]. Therefore, we screened several influenza virus strains isolated in China during the 2009 pandemic.…”

Section: Introductionmentioning

confidence: 99%

IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (H1N1) Virus

et al. 2011

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Pathogenesis of Pandemic Influenza A (H1N1) and Triple-Reassortant Swine Influenza A (H1) Viruses in Mice

Cited by 115 publications

References 44 publications

Differential Host Determinants Contribute to the Pathogenesis of 2009 Pandemic H1N1 and Human H5N1 Influenza A Viruses in Experimental Mouse Models

Differential Host Determinants Contribute to the Pathogenesis of 2009 Pandemic H1N1 and Human H5N1 Influenza A Viruses in Experimental Mouse Models

Immunization with Biodegradable Nanoparticles Efficiently Induces Cellular Immunity and Protects against Influenza Virus Infection

IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (H1N1) Virus

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