Pathogenesis of parodontitis in rheumatic diseases

Detert, J.; Pischon, Nicole; Burmester, G.-R.; Buttgereit, Frank

doi:10.1007/s00393-009-0560-1

Cited by 12 publications

(8 citation statements)

References 149 publications

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“…However, the increasing age of patients is highly associated with the contract of RA and edentulism. Moreover, the growing evidence suggests an association between periodontal disease and systemic diseases such as rheumatoid arthritis [7]. Therefore, patients suffering from RA, show characteristics that confirm to lots of patients daily locating our hospital.…”

Section: Introductionsupporting

confidence: 62%

Short time administration of antirheumatic drugs - Methotrexate as a strong inhibitor of osteoblast's proliferation in vitro

et al. 2012

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IntroductionDue to increasing use of disease modifying antirheumatic drugs (DMARDs) as first line therapy in rheumatic diseases, dental and maxillofacial practitioner should be aware of drug related adverse events. Especially effects on bone-metabolism and its cells are discussed controversially. Therefore we investigate the in vitro effect of short time administration of low dose methotrexate (MTX) on osteoblasts as essential part of bone remodelling cells.MethodsPrimary bovine osteoblasts (OBs) were incubated with various concentrations of MTX, related to tissue concentrations, over a period of fourteen days by using a previously established standard protocol. The effect on cell proliferation as well as mitochondrial activity was assessed by using 3-(4, 5-dimethylthiazol-2-yl) 2, 5-diphenyltetrazolium bromide (MTT) assay, imaging and counting of living cells. Additionally, immunostaining of extracellular matrix proteins was used to survey osteogenic differentiation.ResultsAll methods indicate a strong inhibition of osteoblast`s proliferation by short time administration of low dose MTX within therapeutically relevant concentrations of 1 to 1000nM, without affecting cell differentiation of middle-stage differentiated OBs in general. More over a significant decrease of cell numbers and mitochondrial activity was found at these MTX concentrations. The most sensitive method seems to be the MTT-assay. MTX-concentration of 0,01nM and concentrations below had no inhibitory effects anymore.ConclusionEven low dose methotrexate acts as a potent inhibitor of osteoblast’s proliferation and mitochondrial metabolism in vitro, without affecting main differentiation of pre-differentiated osteoblasts. These results suggest possible negative effects of DMARDs concerning bone healing and for example osseointegration of dental implants. Especially the specifics of the jaw bone with its high vascularisation and physiological high tissue metabolism, suggests possible negative effects of DMARD therapy concerning oral and cranio-maxillofacial bone surgery as could be seen in a similar way in bisphosphonate related osteonecrosis of the jaw.

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Section: Introductionsupporting

confidence: 62%

Short time administration of antirheumatic drugs - Methotrexate as a strong inhibitor of osteoblast's proliferation in vitro

et al. 2012

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“…Augmented systemic MMP-9 levels represented the situation in the inflamed joint. MMP-9 is likely to be involved in degradation of joint collagen [ 22 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

Significance of Circulating and Crevicular Matrix Metalloproteinase-9 in Rheumatoid Arthritis-Chronic Periodontitis Association

Siloşi

Cojocaru

Foia³

et al. 2015

Journal of Immunology Research

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In the recent years, statistically significant associations between rheumatoid arthritis (RA) and periodontal disease have been identified. Emerging as a chronic inflammatory joint disease, RA displays various features and pathogenetic events similar to chronic periodontitis (CP). The purpose of this study was to evaluate the utility of determining systemic and crevicular levels of metalloproteinase-9 (MMP-9) as potential biomarkers for association between RA and CP. A total of fifty-six patients were included in the study. The subjects were categorized into four groups as follows: healthy-control (n = 21), active RA (n = 16), CP (n = 14), and RA-CP association (n = 12). Assessment of serum and crevicular concentrations of total MMP-9 (active and pro-MMP-9) was based on ELISA technique. The results of this study showed statistically significant differences of serum MMP-9 between patients groups and control. Serum levels of MMP-9 were similar in RA and RA-CP associated patients. Gingival crevicular fluid (GCF) recorded increased MMP-9 levels in RA-CP association subjects as compared to CP. Considering that RA-CP association is characterized by a disregulation of the inflammatory response, MMP-9 may play a role in the pathogenesis of RA-CP association. MMP-9 is therefore a sensitive tool in the diagnosis and management of patients affected by this binomial association.

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“…Both the amount and virulence of the microorganisms and the resistance factors of the host (risk factors and immune status) are crucial for the initiation and progression of the periodontal destruction [3]. Besides detailed concepts about microbiological, molecular, and cellular mechanisms, which determine the strength and balance of the cellular and humoral host response in tissues, it became apparent that a complex and primarily endogenous periodontal microflora is responsible for disease initiation and progression.…”

Section: Pathogenesis Of Periodontal Diseasesmentioning

confidence: 99%

“…From an etiologic and pathogenetic point of view, risk factors other than pathogenic bacteria and oral hygiene play a crucial role. These risk factors can influence every sub-step of the pathogenesis, and this explains the individually different manifestations of the disease [3]. The individual risk factors such as age, gender, body mass, and genetic factors (IL-1β polymorphism and HLA gene associations) are the focus of attention.…”

Section: Risk Factors In Periodontitis or Rheumatoid Arthritis Or Bothmentioning

confidence: 99%

The association between rheumatoid arthritis and periodontal disease

et al. 2010

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Chronic, plaque-associated inflammation of the gingiva and the periodontium are among the most common oral diseases. Periodontitis (PD) is characterized by the inflammatory destruction of the periodontal attachment and alveolar bone, and its clinical appearance can be influenced by congenital as well as acquired factors. The existence of a rheumatic or other inflammatory systemic disease may promote PD in both its emergence and progress. However, there is evidence that PD maintains systemic diseases. Nevertheless, many mechanisms in the pathogenesis have not yet been examined sufficiently, so that a final explanatory model is still under discussion, and we hereby present arguments in favor of this. In this review, we also discuss in detail the fact that oral bacterial infections and inflammation seem to be linked directly to the etiopathogenesis of rheumatoid arthritis (RA). There are findings that support the hypothesis that oral infections play a role in RA pathogenesis. Of special importance are the impact of periodontal pathogens, such as Porphyromonas gingivalis on citrullination, and the association of PD in RA patients with seropositivity toward rheumatoid factor and the anti-cyclic citrullinated peptide antibody.

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Pathogenesis of parodontitis in rheumatic diseases

Cited by 12 publications

References 149 publications

Short time administration of antirheumatic drugs - Methotrexate as a strong inhibitor of osteoblast's proliferation in vitro

Short time administration of antirheumatic drugs - Methotrexate as a strong inhibitor of osteoblast's proliferation in vitro

Significance of Circulating and Crevicular Matrix Metalloproteinase-9 in Rheumatoid Arthritis-Chronic Periodontitis Association

The association between rheumatoid arthritis and periodontal disease

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