Pathogenesis of Psoriasis: The Role of Pro-Inflammatory Cytokines Produced by Keratinocytes

Balato, Anna; Balato, Nicola; M, Megna; Schiattarella, Maria; Lembo, Serena; Ayala, Fabio

doi:10.5772/26163

Cited by 12 publications

(9 citation statements)

References 102 publications

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“…Under IFN − γ cytokine environment macrophages are activated and also stimulated to increase cellular activity [5]. Psoriasis is pronounced by Th 1 -Cells disorder, characterized by the production of IFN − γ, TNF − α and TGF − β under the effect of cytokine IL − 12 [13]. TNF − α alone cannot elicit immunologic reaction although secreted from T Cell and APC but can raise a cytokine storm when combined with strong synergism with IL − 17a [14].…”

Section: Amit Kumar Roy Priti Kumar Roy and Ellina Grigorievamentioning

confidence: 99%

“…For any bounded Lebesgue measurable controls and non-negative initial conditions, it is obvious that non-negative bounded solutions to the state system exist [48]. Let us discuss about our constructed optimal control problem (15), (13). In order to obtain an optimal solution, first we discuss its existence by the following theorem.…”

Section: Existence Of Control Problemmentioning

confidence: 99%

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Mathematical insights on psoriasis regulation: Role of Th1 and Th2 cells

Roy

Roy²,

Grigorieva

2018

Mathematical Biosciences and Engineering

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Psoriasis is an autoimmune disorder, characterized by hyper-proliferation of Keratinocytes for the abnormal activation of T Cells, Dendritic Cells (DCs) and cytokine signaling. Interaction of DCs and T Cells enable T Cell to differentiate into Type 1 (Th 1), Type 2 (Th 2) helper T Cell depending on cytokine release. Hyper-proliferation of Keratinocytes may occur due to over expression of pro-inflammatory cytokines secreted by Th 1-Cells viz. Interferon gamma (IFN − γ), Transforming growth factor beta (TGF − β) and Tumor necrosis factor alpha (TNF − α) etc. Deregulation of epidermal happens due to signaling of anti-inflammatory cytokines like Interleukin 10 (IL − 10), Interleukin 4 (IL − 4) etc., released by Th 2-Cells. In this article, we have constructed a set of nonlinear differential equations involving the above cell population for better understanding the impact of cytokines on Psoriasis. System is analyzed introducing therapeutic agent (Biologic / IL − 10) for reducing the hyper-proliferation of Keratinocytes. Effect of Biologic is used as a surrogate of control parameter to reduce the psoriatic lesions. We also studied its effect both in continuous and impulsive dosing method. Our study reveals that impulsive dosing is more applicable compare with continuous dosing to prevent Psoriasis.

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Section: Amit Kumar Roy Priti Kumar Roy and Ellina Grigorievamentioning

confidence: 99%

Section: Existence Of Control Problemmentioning

confidence: 99%

Mathematical insights on psoriasis regulation: Role of Th1 and Th2 cells

Roy

Roy²,

Grigorieva

2018

Mathematical Biosciences and Engineering

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“…The skin is a potential target for oxidative injury, as it is continuously exposed to UV radiation and other environmental stresses generating reactive oxygen species (ROS) [8]. ROS mediated oxidative damage involves a vast number of biological molecules since it causes lipid peroxidation, DNA modification, and secretion of inflammatory cytokines [1].…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress and Human Psoriasis Diseases

Endrias¹,

Menon²,

Wodeyes³

et al. 2020

AJLM

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Psoriasis is a chronic inflammatory skin disease characterized by the immune system activation due to genetic and environmental factors that leads to the development of skin lesions. Reactive oxygen species produced as a result of skin inflammation may cause disorders of the antioxidant defense systems and increased oxidative stress in psoriasis which was proposed to have a consequent function in psoriasis. The study was planned to evaluate oxidative stress by measuring Total Oxidant Capacity, Total Anti-oxidant capacity and Oxidative Stress Index in psoriatic patients. Methodology: A comparative cross-sectional study design was used. A total of 90 participants between age of 18-65 years comprising 45 newly diagnosed psoriatic patients and 45 sex and age matched control groups were enrolled in the study. Result: The present study showed significantly increased levels of serum Total Oxidant Capacity (p<0.001) as well as Oxidative Stress Index (p<0.001) in psoriasis patients as compared to controls and positively correlated with severity and duration of the disease. Total Antioxidant capacity levels were significantly (p<0.001) lower in patients than in controls and negatively correlated with severity and duration of the disease. Conclusion: These results provide evidences regarding the role of increased reactive oxygen species with decreased antioxidant activity in psoriatic patients.

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“…The pathogenesis of psoriasis also involves the infiltration of immune cells into the dermis and epidermis, causing the secretion of inflammatory mediators [8]. Cytokines secreted by immune cells stimulate the keratinocytes, which in turn triggers the formation of lesion plaques [9,10].…”

Section: Introductionmentioning

confidence: 99%

Dihydrochalcone Derivatives from Populus balsamifera L. Buds for the Treatment of Psoriasis

Bélanger

Grenier

Simard

et al. 2019

IJMS

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Psoriasis is a skin disorder characterized by epidermal hyperplasia, hyperkeratosis, and inflammation. The treatments currently available on the market only improve patients’ quality of life and are associated with undesirable side effects. Thus, research leading to the development of new, effective, and safer therapeutic agents is still relevant. Populus balsamifera L. buds were used traditionally by Native Americans to treat various skin pathologies such as eczema and psoriasis. In this study, the antipsoriatic activities of dihydrochalcone derivatives from Populus balsamifera L. buds, known as balsacones, were investigated. The experiments were performed in vitro using a psoriatic skin substitute model. Also, anti-inflammatory and antioxidant activities were investigated. The tested balsacones showed promising antipsoriatic properties by slowing down cell growth and by regulating the expression of involucrin, loricrin, and Ki67 better than methotrexate in psoriatic substitutes. All five tested compounds could be an effective topical treatment for psoriasis, with promising anti-inflammatory and antioxidant actions that may contribute to clinical improvement in patients with psoriasis.

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Pathogenesis of Psoriasis: The Role of Pro-Inflammatory Cytokines Produced by Keratinocytes

Cited by 12 publications

References 102 publications

Mathematical insights on psoriasis regulation: Role of Th<sub>1</sub> and Th<sub>2</sub> cells

Mathematical insights on psoriasis regulation: Role of Th<sub>1</sub> and Th<sub>2</sub> cells

Oxidative Stress and Human Psoriasis Diseases

Dihydrochalcone Derivatives from Populus balsamifera L. Buds for the Treatment of Psoriasis

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