Pathogenesis of the Optic Nerve Lesion in Vitamin A-Deficient Calves

Hayes, K. C.; Nielsen, S. W.; Eaton, H.D.

doi:10.1001/archopht.1968.00980050779019

Cited by 39 publications

(20 citation statements)

References 20 publications

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“…The intracanalicular portion of the optic nerves were removed by cutting a block of sphenoid bone (optic block) approximately 50 x 30 x 30 mm in size. 6 The eyes and the intraorbital portion of the optic nerves were immersed in Zenker's fixative within 10 minutes of euthanasia. The other specimens were fixed for 5 days in 10% neutral buffered formalin.…”

Section: Pathologymentioning

confidence: 99%

Status Spongiosis, Optic Neuropathy, and Retinal Degeneration in Helichrysum argyrosphaerum Poisoning in Sheep and a Goat

Lugt

Olivier

Jordaan³

1996

Vet Pathol

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Abstract. Lesions of natural Helichrysum argyrosphaerum poisoning were studied in eight sheep and one goat. Light microscopic examination revealed widespread, bilaterally symmetrical status spongiosis of the white matter of the brain consistently present in the subependymal area adjacent to the lateral ventricles, cerebellar peduncles, and brain stem in all animals. In three animals, the ultrastructural finding of intramyelinic vacuolation due to splitting of the myelin lamellae at the intraperiod lines indicated myelin edema. There was also mild distension of perivascular and extracellular spaces in the severely affected areas. Significant changes were absent in neurons, glial cells, axons, or blood vessel walls. Myelin edema associated with degeneration and loss of axons and myelin and astrocytic gliosis was present in the intraorbital and intracranial portions of the optic nerves. In the intracanalicular portions of the nerves in three animals that were studied, more chronic lesions consisting of fibrosis and atrophy of the nerve suggested that the optic neuropathy follows compression of the nerve in the optic canal as a result of myelin edema. The toxic principle of the plant also caused a degenerative retinopathy in five animals. The essential histopathologic change was degeneration and loss of the photoreceptor outer segments predominantly in the nontapetal retina. These retinal lesions were associated with hyperplasia and hypertrophy and with migration of the pigmented epithelium, focal retinal separation, and depletion and loss of the nuclear layers.

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Section: Pathologymentioning

confidence: 99%

Status Spongiosis, Optic Neuropathy, and Retinal Degeneration in Helichrysum argyrosphaerum Poisoning in Sheep and a Goat

Lugt

Olivier

Jordaan³

1996

Vet Pathol

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show abstract

“…Dans (2, 8, ll, 12, 19, 30, 35, 37). Çünkü, Yit A yetersizliğine en duyarlı dokular, buzağılarda, retina ve arachnoid viııidir (19).…”

Section: L'amaurose Constitue Un Probleme Sanitaire Non Seulement II unclassified

Buzağilarda Bakarkörlük Ve Vi̇tami̇n a Yetersi̇zli̇ği̇

Altintaş¹

1995

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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“…Böyle bir yassılaşmanın sonucunda da n. opticus'da waller dejenerasyonu görülür. Retinada dejenerasyonlar oluşur ve buna bağlı olarak körlük meydana gelir (4)(5)(6)8,9,18). Bu çalışmadaki olgularda gerek makroskobik ve gerekse mikroskobik olarak; bulbus oculi, canalis opticus ve n. opticus'da lezyon saptanmadı.…”

Section: Tartışma Ve Sonuçunclassified

“…Konjenital körlük, beslenme (3,5,9,11,12,17,18) enfeksiyöz (I, 13-16) ve kalıtsal nedenlere bağlı olarak meydana gelebilmektedir (4,7). Tüm bu etkenler görme yollannda oluşturdukları lezyonlara paralelolarak değişen derecelerde körlüğe neden olmaktadır.…”

Section: Introductionunclassified

AKDENİz BÖLGESİNDE KÖR DOGAN BUZAGILARIN BULBUS OCULI, NERVUS OPTICUS VE SANTRAL sİNİR SİSTEMİNİN PATOLOJİK ANATOMİsİ

Haziroğlu¹

1994

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Pathogenesis of the Optic Nerve Lesion in Vitamin A-Deficient Calves

Cited by 39 publications

References 20 publications

Status Spongiosis, Optic Neuropathy, and Retinal Degeneration in Helichrysum argyrosphaerum Poisoning in Sheep and a Goat

Status Spongiosis, Optic Neuropathy, and Retinal Degeneration in Helichrysum argyrosphaerum Poisoning in Sheep and a Goat

Buzağilarda Bakarkörlük Ve Vi̇tami̇n a Yetersi̇zli̇ği̇

AKDENİz BÖLGESİNDE KÖR DOGAN BUZAGILARIN BULBUS OCULI, NERVUS OPTICUS VE SANTRAL sİNİR SİSTEMİNİN PATOLOJİK ANATOMİsİ

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