Pathogenetic features of lipid and protein peroxide oxidation due to experimental acute ne-crotizing pancreatitis

Maksymyuk, Vitaliy V.; Шеремет, М. І.; Tarabanchuk, Volodimir V.; Shidlovskyi, Olexandr V.; BRODOVSKYI, Sergey P.; Zhulkevych, I. V.; GYRLA, Yan V.; Ткачук, Н. П.; Bilookyi, O. V.; GRESKO, Michael M.; GRESKO, Marina D.; Holiar, O. I.

doi:10.31688/abmu.2019.54.2.03

Cited by 1 publication

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References 17 publications

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“…Наявність 2-х критеріїв діагностували у 9 (17,31%) хворих (1 група), SIRS-3 -у 25 (48,08%) -2 група, SIRS-4 -у 18 (34,62%) -3 група. Усім хворим проводилось комплексне уніфіковане лікування, що включало передопераційну підготовку, обов'язкове оперативне втручання та комплексне післяопераційне лікування[2,5,7]. Концентрації простацикліну і тромбоксану А 2 (Т х А 2 ) визначали методом радіоімунного аналізу за вмістом їх стабільних метаболітів у крові: відповідно 6-кето-ПГF 1α та тромбоксану В 2 (Т х В 2 ), за допомогою наборів 125 І-Prostaglandіn-F 1α RІA Kіt та 125 І-Tromboxane-B 2 RІA Kіt (Угорщина).…”

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The Sіgnіfіcance of Changes Іn Prіmary Hemostasіs Durіng Abdomіnal Sepsіs as a Possіble Mechanіsm of Spіke Formatіon

Polyovyy¹,

Savchuk²,

Sydorchuk³

et al. 2023

Khark. Surg. Sch.

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Summary. Introduction. Abdominal sepsis (AS) is the most serious complication of inflammatory processes in the abdominal cavity, characterized by high mortality and morbidity. Violation of hemostasis is one of the key components of the pathogenesis of sepsis. Goal. Establishing the pattern of violations in the system of thrombocyte-vascular hemostasis in patients with abdominal sepsis in the postoperative period, as a prerequisite for the occurrence of adhesions. Materials and methods. The study covers observation of 52 patients with various forms of AS, aged 18-69 years (41.93±3.47). The control group consisted of 17 patients who underwent planned surgical interventions not related to the peritoneal cavity. The dynamics of the content of soluble fibrin-monomer complexes, prostacyclin and thromboxane were determined by the content of their stable metabolites in the blood. Results and discussion. Probable correlative dependences between the content of fibrin-monomer complexes in the blood and the concentration of TxB2 (positive correlation) and the level of prostacyclin in the blood plasma (negative relationship) were revealed. Identified violations in the system of primary hemostasis in patients with AS indicate the need for active correction of changes in thromboxane-prostacyclin systems in order to prevent thrombotic postoperative complications of a septic nature. Conclusions. Identified violations in the system of primary hemostasis in AS already on the first day after surgery indicate the need for active correction of changes in thromboxane-prostacyclin systems in order to prevent thrombotic postoperative complications of a septic nature. Taking into account the high risk of adhesion formation due to inflammatory processes of the peritoneum, it is advisable to consider the identified violations of primary hemostasis as a factor in the pathogenesis of adhesion disease.

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