Pathogenic effects of Desulfovibrio in the gut on fatty liver in diet-induced obese mice and children with obesity

Lin, Yu‐Cheng; Lin, Hsueh-Fang; Wu, Chi-Chien; Chen, Chun-Liang; Ni, Yen‐Hsuan

doi:10.1007/s00535-022-01909-0

Cited by 39 publications

(24 citation statements)

References 37 publications

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“…In addition, most of the studies remain at the level of family and genus, and the differences at the species level have not been deeply explored. As some studies have described [ 12 , 13 ], the physiological effects of different species may differ. Therefore, it is of great significance to explore the differences of different Desulfovibrio in the guts of patients and healthy people to analyze its mechanism of action.…”

Section: Discussionmentioning

confidence: 99%

“…Based on the evaluation of the tolerance of our isolated strains to SGF and SIF, LC-derived Desulfovibrio is more resistant to SIF than HV-derived Desulfovibrio , so they might be easier to colonize and proliferate in the intestines, which may be related to the increased abundance of Desulfovibrio in the intestines of patients with liver diseases [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…The NAFLD activity score has been positively correlated with the relative abundance of Desulfovibrio [ 11 ]. An increased abundance of Desulfovibrio was found in feces of obese children with NAFLD compared to those without NAFLD, and intragastric gavage with D. piger increased intestinal permeability and aggravated liver steatosis and fibrosis in obese mice [ 12 ]. On the contrary, D. vulgaris was enriched in Astragalus polysaccharide-treated, high-fat-diet-fed mice, which could produce acetic acid and showed an anti-NAFLD effect [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Diversity and Comparison of Intestinal Desulfovibrio in Patients with Liver Cirrhosis and Healthy People

Ren

Shi

et al. 2023

Microorganisms

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Desulfovibrio belongs to Sulfate-reducing bacteria (SRB), which are widely present in anaerobic environments, including the human gut. Desulfovibrio has been associated with many human diseases, including chronic liver disease. However, the characteristics and difference of Desulfovibrio from fecal samples of healthy volunteers (HV) and patients with liver cirrhosis (LC) have not been fully elucidated. Here, we isolated Desulfovibrio from the feces of 6 HV and 9 LC, and 88 Desulfovibrio strains were obtained. In the feces of HV, 55% of isolated strains were D. desulfuricans, followed by D. intestinalis (15%), D. simplex (11%), D. piger (9%), D. legallii (4%), Cupidesulfovibrio oxamicus (4%) and D. fairfieldensis (2%). However, only D. desulfuricans (60%) and C. oxamicus (40%) were isolated from fecal samples of patients with LC. Our results suggest that there was a significant difference in the desulfurization ability and the H2S production ability of different Desulfovibrio. Desulfovibrio. Furthermore, we found that Desulfovibrio isolated from the patients with LC generally had a higher hydrogen sulfide production capacity, gastrointestinal tolerance, and levels of antibiotic resistance than the same species isolated from HV. Our findings suggested that Desulfovibrio may be associated with the occurrence and development of liver cirrhosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Diversity and Comparison of Intestinal Desulfovibrio in Patients with Liver Cirrhosis and Healthy People

Ren

Shi

et al. 2023

Microorganisms

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“…The genus Flavonifractor such as Flavonifractor plautii , a potential pathogen, was related with the suppressed immune response in mice . Notably, the genus Desulfovibrio in the gut had the pathogenic effects on fatty liver in diet-induced obese mice and children with obesity …”

Section: Discussionmentioning

confidence: 99%

“…48 Notably, the genus Desulfovibrio in the gut had the pathogenic effects on fatty liver in diet-induced obese mice and children with obesity. 49 Numerous studies have demonstrated that microbiotaderived metabolites such as SCFAs and indole derivatives are important signals and regulators of the host-microbial crosstalk closely related to pathophysiological conditions. 50 In this study, genera Bif idobacterium, Lactobacillus, and Akkermansia were significantly positively correlated with the levels of indole and IAA.…”

Section: ■ Discussionmentioning

confidence: 99%

Structural Insights into Amelioration Effects of Quercetin and Its Glycoside Derivatives on NAFLD in Mice by Modulating the Gut Microbiota and Host Metabolism

Shi

Zhang

Lei

et al. 2022

J. Agric. Food Chem.

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The sugar moieties of natural flavonoids determine their absorption, bioavailability, and bioactivity in humans. To explore structure-dependent bioactivities of quercetin, isoquercetin, and rutin, which have the same basic skeleton linking different sugar moieties, we systemically investigated the ameliorative effects of dietary these flavonoids on high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) of mice. Our results revealed that isoquercetin exhibits the strongest capability in improving NAFLD phenotypes of mice, including body and liver weight gain, glucose intolerance, and systemic inflammation in comparison with quercetin and rutin. At the molecular level, dietary isoquercetin markedly ameliorated liver dysfunction and host metabolic disorders in mice with NAFLD. At the microbial level, the three flavonoids compounds, especially isoquercetin, can effectively regulate the gut microbiota composition, such as genera Akkermansia, Bifidobacterium, and Lactobacillus, which were significantly disrupted in NAFLD mice. These comparative findings offer new insights into the structure-dependent activities of natural flavonoids for NAFLD treatment.

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Gut microbiota and fecal volatilome profile inspection in metabolically healthy and unhealthy obesity phenotypes

Calabrese,

Genchi,

Serale

et al. 2024

J Endocrinol Invest

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Background People with metabolically healthy (MHO) and metabolically unhealthy obesity (MUO) differ for the presence or absence of cardio-metabolic complications, respectively. Objective Based on these differences, we are interested in deepening whether these obesity phenotypes could be linked to changes in microbiota and metabolome profiles. In this respect, the overt role of microbiota taxa composition and relative metabolic profiles is not completely understood. At this aim, biochemical and nutritional parameters, fecal microbiota, metabolome and SCFA compositions were inspected in patients with MHO and MUO under a restrictive diet regimen with a daily intake ranging from 800 to 1200 kcal. Methods Blood, fecal samples and food questionnaires were collected from healthy controls (HC), and an obese cohort composed of both MHO and MUO patients. Most impacting biochemical/anthropometric variables from an a priori sample stratification were detected by applying a robust statistics approach useful in lowering the background noise. Bacterial taxa and volatile metabolites were assessed by qPCR and gas chromatography coupled with mass spectrometry, respectively. A targeted GC–MS analyses on SCFAs was also performed. Results Instructed to follow a controlled and restricted daily calorie intake, MHO and MUO patients showed differences in metabolic, gut microbial and volatilome signatures. Our data revealed higher quantities of specific pro-inflammatory taxa (i.e., Desulfovibrio and Prevotella genera) and lower quantities of Clostridium coccoides group in MUO subset. Higher abundances in alkane, ketone, aldehyde, and indole VOC classes together with a lower amount of butanoic acid marked the faecal MUO metabolome. Conclusions Compared to MHO, MUO subset symptom picture is featured by specific differences in gut pro-inflammatory taxa and metabolites that could have a role in the progression to metabolically unhealthy status and developing of obesity-related cardiometabolic diseases. The approach is suitable to better explain the crosstalk existing among dysmetabolism-related inflammation, nutrient intake, lifestyle, and gut dysbiosis.

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Pathogenic effects of Desulfovibrio in the gut on fatty liver in diet-induced obese mice and children with obesity

Cited by 39 publications

References 37 publications

Diversity and Comparison of Intestinal Desulfovibrio in Patients with Liver Cirrhosis and Healthy People

Diversity and Comparison of Intestinal Desulfovibrio in Patients with Liver Cirrhosis and Healthy People

Structural Insights into Amelioration Effects of Quercetin and Its Glycoside Derivatives on NAFLD in Mice by Modulating the Gut Microbiota and Host Metabolism

Gut microbiota and fecal volatilome profile inspection in metabolically healthy and unhealthy obesity phenotypes

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