Pathogenic Mechanisms and Therapeutic Implication in Nickel-Induced Cell Damage

Abstract

Background: Nickel (Ni) is mostly applied in plenty industrial sections like printing inks, welding, alloy, electronics and electrical professions. Occupational or environmental exposure to nickel may lead to cancer, allergy reaction, nephrotoxicity, hepatotoxicity, neurotoxicity as well as cell damage, apoptosis and oxidative stress. Method: In here we focused on published studies about cell death, carcinogenicity, allergy reactions and neurotoxicity, and promising agents for prevention and treatment the toxicity by Ni. Results: Our review showed that in last years, more researches have focused on reactive oxygen species formation, oxidative stress, DNA damages, apoptosis, interaction with involving receptors in allergy and mitochondrial damages in neuron induced by Ni. Conclusion: The gathering data in this paper provides useful information about the main toxicities induced by Ni also, their fundamental mechanisms, and how to discover new ameliorative agents for prevention and treatment, by reviewing agents with protective and therapeutic consequences on Ni induced toxicity.

Occupational disease predictors in the nickel pyrometallurgical production: a prospective cohort observation

“…Despite wide use of metallic nickel in a range of industries and production, occupational health of nickel workers still remains poorly described. Nickel exhibits carcinogenic, toxic and allergic properties, when its toxic mechanism is mediated through cell damage in a number of pathways [ 12 ]; therefore, this chemical hazard may affect human health in many ways, also given that exposure limits are likely exceeded in its production sites. Exposure assessment studies, including those not in nickel production, where nickel is somehow used [ 13 , 14 ], are also quite sporadic and very often outdated [ 15 ], but the production technology has likely improved in the last decades and the workers’ exposure may have become less aggressive, but we found no high-quality exposure assessment presentations in the published literature in the last ten years.…”

Dietary Toxicity of Heavy Metals; One Health Perspective

“…It is used to create steels that are heat and corrosion resistant. Acute toxicity and immunological problems may result from its usage in the manufacture of nickel salts,the fabrication of NI-CD batteries, the development of moulds for the hollow glass industry, the production of coins, jewelry and medical and dental implants (Al-Lami et al 2020;Salimi et al 2020). Animals and plants can become poisonous to nickel if they consume polluted water.…”

Cellulose and Vanadium Plasmonic Sensor to Measure Ni2+ Ions

“…Furthermore, the K value reported in this study had a higher affinity constant of 0.0310 ppb −1 (1.819 × 10 6 M −1 ) compared to other existing SPR sensors [65,66] (see Table 3). 3 nanocrystalline cellulose-graphene oxide, 4 polypyrrole-chitosan, 5 silver nanoparticles capped with 3-mercapto-1propanesulfonic acid sodium salt, 6 vanadium-cellulose nanocrystals-hexadecyltrimethylammonium bromide.…”

“…Occupational exposure is associated with the workers that engaged in refining, electroplating, and welding, which may develop severe chronic diseases of the upper respiratory tract, including hypertrophic rhinitis, nasal sinusitis, anosmia, nasal polyposis, and perforation of the nasal septum. While casual exposure to nickel occurs mainly in the use of shiny things such as coins, watches, jewelry, zippers, exposure causes nickel allergies and dermatitis [6][7][8][9][10][11]. Generally, the concentration of nickel is very high in food compared to the environment [12][13][14].…”