Pathogenic role of anti-M3 muscarinic acetylcholine receptor immune response in Sjögren's syndrome

Sumida, Takayuki; Iizuka, Mana; Asashima, Hiromitsu; Tsuboi, Hiroto; Matsumoto, Isao

doi:10.1016/j.lpm.2012.05.019

Cited by 18 publications

(11 citation statements)

References 22 publications

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“…Wang et al [69] found that Th17 cells in SS patients were significantly higher than the control group, and high Th17 expression was associated with the pathogenesis of SS. Sumida et al [70] studied the expression of Th17 cells in the animal model of M3R-/-induced salivary gland dry mice, and found that Th17 cells and IL-17 were detected in the salivary glands and serum of mice, indicating IL-17 in SS model mice rised. The level of IL-17 in the labial gland and peripheral blood of C57BL/6.…”

Section: Th17/treg Imbalance and Primary Sjogren's Syndromementioning

confidence: 99%

Research Progress of Th17/Treg Cells and Their Transcription Factors in Autoimmune Diseases

Hou¹,

Mu²,

Wang³

2019

AJCEM

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Helper T cell 17 (Th17) being a new cell subset of CD4+T in the body, which is different from Th1 and Th2 cells, have independent mechanisms of differentiation and developmental regulation. Th17 cells mainly secrete various cytokines such as IL-17, IL-6 and TNF-α, which induce inflammation. Treg cells are T cells with high expression of CD25 differentiated by T cells under the action of certain cytokines, namely CD4+CD25+(hi) Foxp3+T cells, which can regulate the immune response mediated by effector cells and are an important line of defense for human autoimmune. Therefore, Treg cells play an important role in maintaining immune tolerance of the body. As an important subset of T cells, Treg cells have an inhibitory effect on inflammation. Its working principle is to selectively inhibit autoreactive T cells and effector T cells so as to maintain the body's immune balance, and normal quantity and function help the immune system to its antigen stimulation, establishing a good state of tolerance. The expression of Treg cells increased, can avoid the occurrence of autoimmune diseases. Treg cells inhibit the differentiation of Th17 cells by down-regulating the expression of IL-23 and IL-17 or by its specific transcription factor Foxp3; similarly, inhibition of Th17 cell production can promote the development of Treg cells. Both Th17 and Treg cells are functionally inhibited. Th17 cells promote inflammatory reaction, and Treg cells suppress immune reaction. Numerous cytokines are involved in regulation. For example, IL-6 and IL-21 can inhibit Foxp3 and promote the expression of RORγt, thereby inhibiting Treg cells and inducing the differentiation of Th17 cells. In the absence of IL-6 and other pro-inflammatory factors, TGF-β enhances the inhibitory effect of Foxp3 on RORγt and promotes the growth and development of Treg cells. The anti-inflammatory factor IL-10 also induces Treg cells to inhibit the reaction of Th17 cells. The effects of Treg and Th17 cells are normally in a dynamic equilibrium. Once the balance is imbalanced, autoimmune diseases will occur. This article reviews the differentiation, function and research progress of Th17/Treg cells in autoimmune diseases.

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Section: Th17/treg Imbalance and Primary Sjogren's Syndromementioning

confidence: 99%

Research Progress of Th17/Treg Cells and Their Transcription Factors in Autoimmune Diseases

Hou¹,

Mu²,

Wang³

2019

AJCEM

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“…A human retrovirus cloned from a salivary gland of a patient has led to the hypothesis that SS is an unusual autoimmune reaction to a common infection with HRV5 in susceptible individuals (Venables and Rigby, 1997). Anti-M3 muscarinic acetylcholine receptor immune autoantibodies have been reported and appear to play a pathogenic role in a subset of patients with SS (Sumida et al, 2012).…”

Section: Pathogenesismentioning

confidence: 99%

Immunology of Diseases of the Oral Cavity

Challacombe

Shirlaw

2015

Mucosal Immunology

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“…M3R is a transmembrane protein that regulates calcium entry to promote salivation and lacrimation upon ligation. Anti-M3R autoantibodies affect salivary gland function [41] and have been detected in children with SS [42]. Anti-M3R antibodies recognizing the second extracellular loop decreased calcium influx in a human salivary gland cell line suggesting a pathogenic role in exocrine gland dysfunction [43].…”

Section: Pathogenesismentioning

confidence: 99%

Childhood Sjögren syndrome

Lieberman

2013

Current Opinion in Rheumatology

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Purpose of review Sjögren syndrome (SS) is a chronic autoimmune disease affecting lacrimal and salivary glands and potentially involving extraglandular manifestations. While common in adults, the prevalence and prognosis of childhood SS is unknown, in part due to lack of child-specific diagnostic and classification criteria. This review discusses difficulties in diagnosing childhood SS and highlights recent findings in SS treatment and pathogenesis from studies in adults and animal models over the past 18 months. Recent findings Studies of rituximab show some therapeutic potential in adult SS while newer modalities including gene therapy and mesenchymal stem cell transfer are promising. The pathogenesis of SS is emerging, including roles of T and B lymphocytes, autoantibodies, interferons, and glandular epithelial cells. Specific recent notable findings in SS pathogenesis include identification of a type II interferon signature in salivary glands of SS patients, characterization of salivary gland-infiltrating T cell subsets, and characterization of anti-muscarinic acetylcholine receptor type 3 autoantibodies. Summary Childhood SS is a poorly defined and underdiagnosed autoimmune disease which requires child-specific criteria in order to study disease burden and prognosis. Studies in adults and animal models continue to elucidate new potential diagnostic and therapeutic targets, which may be relevant for childhood SS.

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Pathogenic role of anti-M3 muscarinic acetylcholine receptor immune response in Sjögren's syndrome

Cited by 18 publications

References 22 publications

Research Progress of Th17/Treg Cells and Their Transcription Factors in Autoimmune Diseases

Research Progress of Th17/Treg Cells and Their Transcription Factors in Autoimmune Diseases

Immunology of Diseases of the Oral Cavity

Childhood Sjögren syndrome

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