Pathogenic Roles of RNA-Binding Proteins in Sarcomas

Yu, Hai; Kawachi, Asuka; He, Xiaodong; Yoshimi, Akihide

doi:10.3390/cancers14153812

Cited by 2 publications

(1 citation statement)

References 89 publications

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“…Alternative polyadenylation is utilized to explain the work of generating transcripts and modifying the coding sequence to impact the protein [19]. RNA stability is closely related to its poly(A) tail at the 3′ end, and some RBPs can stabilize the RNA structure by capping the RNA poly(A) tail with an N7 methylated guanine (m7GpppN) [20]. RBPs can also recognize cis motifs or zip codes in the 3′-untranslated region (3′-UTR) of RNA to regulate the localization of RNA in cells.…”

Section: Rbps Regulate Rnas At the Posttranscriptional Levelmentioning

confidence: 99%

Functional Role of RBP in Osteosarcoma: Regulatory Mechanism and Clinical Therapy

Que,

Yang,

Wang

et al. 2023

Analytical Cellular Pathology

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Malignant bone neoplasms can be represented by osteosarcoma (OS), which accounts for 36% of all sarcomas. To reduce tumor malignancy, extensive efforts have been devoted to find an ideal target from numerous candidates, among which RNA-binding proteins (RBPs) have shown their unparalleled competitiveness. With the special structure of RNA-binding domains, RBPs have the potential to establish relationships with RNAs or small molecules and are considered regulators of different sections of RNA processes, including splicing, transport, translation, and degradation of RNAs. RBPs have considerable significant roles in various cancers, and experiments revealed that there was a strong association of RBPs with tumorigenesis and tumor cell progression. Regarding OS, RBPs are a new orientation, but achievements in hand are noteworthy. Higher or lower expression of RBPs was first found in tumor cells compared to normal tissue. By binding to different molecules, RBPs are capable of influencing tumor cell phenotypes through different signaling pathways or other axes, and researches on medical treatment have been largely inspired. Exploring the prognostic and therapeutic values of RBPs in OS is a hotspot where diverse avenues on regulating RBPs have achieved dramatical effects. In this review, we briefly summarize the contribution of RBPs and their binding molecules to OS oncogenicity and generally introduce distinctive RBPs as samples. Moreover, we focus on the attempts to differentiate RBP’s opposite functions in predicting prognosis and collect possible strategies for treatment. Our review provides forwards insight into improving the understanding of OS and suggests RBPs as potential biomarkers for therapies.

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Section: Rbps Regulate Rnas At the Posttranscriptional Levelmentioning

confidence: 99%

Functional Role of RBP in Osteosarcoma: Regulatory Mechanism and Clinical Therapy

Que,

Yang,

Wang

et al. 2023

Analytical Cellular Pathology

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Extracellular vesicle-associated IGF2BP3 tunes Ewing sarcoma cell migration and affects PI3K/Akt pathway in neighboring cells

et al. 2023

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Ewing sarcoma (EWS) is a challenging pediatric cancer characterized by vast intra-tumor heterogeneity. We evaluated the RNA-binding protein IGF2BP3, whose high expression correlates with a poor prognosis and an elevated tendency of metastases, as a possible soluble mediator of inter-cellular communication in EWS. Our data demonstrate that (i) IGF2BP3 is detected in cell supernatants, and it is released inside extracellular vesicles (EVs); (ii) EVs from IGF2BP3-positive or IGF2BP3-negative EWS cells reciprocally affect cell migration but not the proliferation of EWS recipient cells; (iii) EVs derived from IGF2BP3-silenced cells have a distinct miRNA cargo profile and inhibit the PI3K/Akt pathway in recipient cells; (iv) the 11 common differentially expressed miRNAs associated with IGF2BP3-positive and IGF2BP3-negative EVs correctly group IGF2BP3-positive and IGF2BP3-negative clinical tissue specimens. Overall, our data suggest that IGF2BP3 can participate in the modulation of phenotypic heterogeneity.

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Pathogenic Roles of RNA-Binding Proteins in Sarcomas

Cited by 2 publications

References 89 publications

Functional Role of RBP in Osteosarcoma: Regulatory Mechanism and Clinical Therapy

Functional Role of RBP in Osteosarcoma: Regulatory Mechanism and Clinical Therapy

Extracellular vesicle-associated IGF2BP3 tunes Ewing sarcoma cell migration and affects PI3K/Akt pathway in neighboring cells

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